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Gene Review

TRPC7  -  transient receptor potential cation...

Homo sapiens

Synonyms: Short transient receptor potential channel 7, TRP-7, TRP7, Transient receptor protein 7, TrpC7, ...
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Psychiatry related information on TRPC7

  • BACKGROUND: As altered storage-operated calcium (Ca(2+)) entry (SOCE) may affect Ca(2+) homeostasis in bipolar disorder (BD), we determined whether changes occur in the expression of TRPC7 and SERCA2s, proteins implicated or known to be involved in SOCE, in B lymphoblast cell lines (BLCLs) from BD-I patients and comparison subjects [1].

High impact information on TRPC7

  • In DT40 B lymphocytes, Canonical Transient Receptor Potential 7 (TRPC7) functions as a diacylglycerol-activated non-selective cation channel [2].
  • Native TRPC7 channel activation by an inositol trisphosphate receptor-dependent mechanism [2].
  • These responses were absent in TRPC7-/- cells but could be restored by transfection with human TRPC7 [3].
  • In comparison with untransfected cells depletion of intracellular calcium stores in hTRP7-expressing cells, using either carbachol or thapsigargin, produced a marked increase in the subsequent level of Ca(2+) influx [4].
  • For functional analysis, we heterologously expressed hTRP7 cDNA in an human embryonic kidney cell line [4].

Biological context of TRPC7


Anatomical context of TRPC7


Associations of TRPC7 with chemical compounds

  • However, when stably expressed in HEK-293 cells, TRPC7 can be activated by either Ca(2+) store depletion or PLC activation [10].
  • TRPM2 (previously designated TRPC7 or LTRPC2) is a Ca2+-permeable nonselective cation channel that contains a C-terminal enzymatic domain with pyrophosphatase activity, which specifically binds ADP-ribose [11].
  • In contrast, treatment with the thrombin-tethered ligand receptor peptide TRP-7 (SFLLRNP) induced IL-6 production, but at lower levels than that induced by native alpha-thrombin [12].
  • In amphibians only mammalian GnRH ([Arg8] GnRH) and type II GnRH (chicken GnRH II, [His5, Trp7, Tyr8] GnRH) have been identified [13].
  • The immunoreactive peak in the final purification step had a retention time identical to that of Trp7, Leu8-GnRH and an UV absorbance (280 nm) peak appropriate for two tryptophan residues in the peptide, as in Trp7, Leu8-GnRH [8].

Other interactions of TRPC7

  • RESULTS: TRPC7 mRNA levels were significantly lower in BLCLs from BD-I patients with high BLCL [Ca(2+)]B compared with those showing normal [Ca(2+)]B (-33%, p =.017) and with BD-II patients (-48%, p =.003), major depressive disorder patients (-47%, p =.049) and healthy subjects (-33%, p =.038) [1].
  • TRP-14 was also a pulmonary vasodilator with a t1/2R value of 0.8 +/- 0.09 min at a concentration of 10(-7) M; both TRP-14 and TRP-7 were approximately 3-log less potent than equimolar alpha-thrombin.(ABSTRACT TRUNCATED AT 250 WORDS)[14]

Analytical, diagnostic and therapeutic context of TRPC7

  • Evidence from co-immunoprecipitation experiments indicates that a TRPC1-TRPC3-TRPC7 complex, predicted from siRNA results, does exist [15].
  • We investigated, by using the patch clamp technique, Ca2+-mediated regulation of heterologously expressed TRPC6 and TRPC7 proteins in HEK293 cells, two closely related homologues of the transient receptor potential (TRP) family and molecular candidates for native receptor-operated Ca2+ entry channels [16].
  • The major GnRH molecular form co-eluted with salmon brain GnRH (Trp7, Leu8-GnRH) in four different HPLC systems which were specifically designed to separate the four natural vertebrate GnRHs (mammalian, salmon, chicken I and II) [8].


  1. Altered TRPC7 gene expression in bipolar-I disorder. Yoon, I.S., Li, P.P., Siu, K.P., Kennedy, J.L., Macciardi, F., Cooke, R.G., Parikh, S.V., Warsh, J.J. Biol. Psychiatry (2001) [Pubmed]
  2. Native TRPC7 channel activation by an inositol trisphosphate receptor-dependent mechanism. Vazquez, G., Bird, G.S., Mori, Y., Putney, J.W. J. Biol. Chem. (2006) [Pubmed]
  3. The role of canonical transient receptor potential 7 in B-cell receptor-activated channels. Lievremont, J.P., Numaga, T., Vazquez, G., Lemonnier, L., Hara, Y., Mori, E., Trebak, M., Moss, S.E., Bird, G.S., Mori, Y., Putney, J.W. J. Biol. Chem. (2005) [Pubmed]
  4. Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx. Riccio, A., Mattei, C., Kelsell, R.E., Medhurst, A.D., Calver, A.R., Randall, A.D., Davis, J.B., Benham, C.D., Pangalos, M.N. J. Biol. Chem. (2002) [Pubmed]
  5. Physiological induction of transient receptor potential canonical proteins, calcium entry channels, in human myometrium: influence of pregnancy, labor, and interleukin-1 beta. Dalrymple, A., Slater, D.M., Poston, L., Tribe, R.M. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  6. PGE2-induced apoptotic cell death in K562 human leukaemia cells. Föller, M., Kasinathan, R.S., Duranton, C., Wieder, T., Huber, S.M., Lang, F. Cell. Physiol. Biochem. (2006) [Pubmed]
  7. TRPC7 is a receptor-operated DAG-activated channel in human keratinocytes. Beck, B., Zholos, A., Sydorenko, V., Roudbaraki, M., Lehen'kyi, V., Bordat, P., Prevarskaya, N., Skryma, R. J. Invest. Dermatol. (2006) [Pubmed]
  8. Multiple molecular forms of gonadotropin-releasing hormone in teleost fish brain. King, J.A., Millar, R.P. Peptides (1985) [Pubmed]
  9. The substance P receptor on rat mast cells and in human skin. Piotrowski, W., Devoy, M.A., Jordan, C.C., Foreman, J.C. Agents Actions (1984) [Pubmed]
  10. Canonical transient receptor potential TRPC7 can function as both a receptor- and store-operated channel in HEK-293 cells. Lièvremont, J.P., Bird, G.S., Putney, J.W. Am. J. Physiol., Cell Physiol. (2004) [Pubmed]
  11. Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes. Beck, A., Kolisek, M., Bagley, L.A., Fleig, A., Penner, R. FASEB J. (2006) [Pubmed]
  12. Thrombin induces IL-6 production in fibroblasts and epithelial cells. Evidence for the involvement of the seven-transmembrane domain (STD) receptor for alpha-thrombin. Sower, L.E., Froelich, C.J., Carney, D.H., Fenton, J.W., Klimpel, G.R. J. Immunol. (1995) [Pubmed]
  13. Molecular cloning, distribution and pharmacological characterization of a novel gonadotropin-releasing hormone ([Trp8] GnRH) in frog brain. Yoo, M.S., Kang, H.M., Choi, H.S., Kim, J.W., Troskie, B.E., Millar, R.P., Kwon, H.B. Mol. Cell. Endocrinol. (2000) [Pubmed]
  14. Receptor mechanism of thrombin-mediated pulmonary vasodilation in neonates. Pinheiro, J.M., Andersen, T.T., Malik, A.B. Am. J. Physiol. (1993) [Pubmed]
  15. Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells. Zagranichnaya, T.K., Wu, X., Villereal, M.L. J. Biol. Chem. (2005) [Pubmed]
  16. Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells. Shi, J., Mori, E., Mori, Y., Mori, M., Li, J., Ito, Y., Inoue, R. J. Physiol. (Lond.) (2004) [Pubmed]
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