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Gene Review

RPS10  -  ribosomal protein S10

Homo sapiens

 
 
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Disease relevance of RPS10

 

High impact information on RPS10

  • In maize (Zea mays), Rps10 has not acquired an extension upon transfer but can be readily imported into mitochondria [2].
  • Using site directed mutagenesis, we changed residues in the first 20 amino acids of the mitochondrial encoded soybean (Glycine max) rps10 to the corresponding amino acids in the nuclear encoded maize Rps10 until import was achieved [2].
  • Cloning and transcriptional analysis show that there are two rps10 genes in the rice nuclear genome and that their transcripts differ in abundance [3].
  • Acquisition of the 5' flanking region might have accelerated the activation of the mitochondrial rps10 gene which was transferred to the nuclear genome [3].
  • Transfer of the mitochondrial rps10 gene to the nucleus in rice: acquisition of the 5' untranslated region followed by gene duplication [3].
 

Biological context of RPS10

  • The RPS10 polypeptide of 129 amino acids is encoded by two exons of 307 bp and 80 bp respectively, which are separated by a 774-bp class-II intron [4].
  • The duplicated rps10 genes have since been translocated to different chromosomes, because the two rps10 genes were mapped on chromosomes 6 and 12 by RFLP analysis [3].
  • Using microarray analysis and quantitative RT-polymerase chain reaction, we found an increase in c-myc-regulated gene expression including an induction of ribosomal subunit messenger RNA's (RPS 10, RPL 21) and rRNA (18S) [5].
 

Anatomical context of RPS10

  • Western analysis detected the RPS10 protein in the soluble fraction of rice mitochondria, although neither RPS10 has any obvious N-terminal presequence for targeting to mitochondria [3].
 

Other interactions of RPS10

 

Analytical, diagnostic and therapeutic context of RPS10

  • Genomic sequence analysis indicated that each rps10 gene has an intron in the 5' untranslated region (5' UTR) and that these intron sequences are homologous to each other [3].

References

  1. A protein-RNA interaction network facilitates the template-independent cooperative assembly on RNA polymerase of a stable antitermination complex containing the lambda N protein. Mogridge, J., Mah, T.F., Greenblatt, J. Genes Dev. (1995) [Pubmed]
  2. Adaptations required for mitochondrial import following mitochondrial to nucleus gene transfer of ribosomal protein S10. Murcha, M.W., Rudhe, C., Elhafez, D., Adams, K.L., Daley, D.O., Whelan, J. Plant Physiol. (2005) [Pubmed]
  3. Transfer of the mitochondrial rps10 gene to the nucleus in rice: acquisition of the 5' untranslated region followed by gene duplication. Kubo, N., Jordana, X., Ozawa, K., Zanlungo, S., Harada, K., Sasaki, T., Kadowaki, K. Mol. Gen. Genet. (2000) [Pubmed]
  4. Splicing and editing of rps10 transcripts in potato mitochondria. Zanlungo, S., Quiñones, V., Moenne, A., Holuigue, L., Jordana, X. Curr. Genet. (1995) [Pubmed]
  5. Transcriptional regulators of ribosomal biogenesis are increased in the unloaded heart. Razeghi, P., Buksinska-Lisik, M., Palanichamy, N., Stepkowski, S., Frazier, O.H., Taegtmeyer, H. FASEB J. (2006) [Pubmed]
 
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