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SLC30A5  -  solute carrier family 30 (zinc...

Homo sapiens

Synonyms: FLJ12496, FLJ12756, MGC5499, Solute carrier family 30 member 5, UNQ863/PRO1879, ...
 
 
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Disease relevance of SLC30A5

 

High impact information on SLC30A5

  • Analysis of gene-expression profiles in murine hearts by means of an oligonucleotide microarray disclosed that a subset of genes encoding immediate-early response factors (IEGs) and heat shock proteins (HSPs) were down-regulated in Znt5-null mice [2].
  • Furthermore, we showed that expression of ZnT5 mRNA was up-regulated by the endoplasmic reticulum stress in various cell lines [3].
  • Furthermore, co-immunoprecipitation studies revealed that ZnT5 and ZnT6 formed hetero-oligomers, whereas ZnT7 formed homo-oligomers [4].
  • The inactive ALP protein in DT40 cells deficient in both ZnT5 and ZnT7 genes was transported to cytoplasmic membrane like the active ALP protein in the wild-type cells [5].
  • A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane [6].
 

Biological context of SLC30A5

 

Anatomical context of SLC30A5

  • Localisation of SLC30A5 at the apical human enterocyte/colonocyte membrane and also at the apical membrane of Caco-2 cells was demonstrated by immunohistochemistry [9].
  • In the human placental cell line JAR, however, expression at the mRNA level of a number of Zn transporters is not modified by Zn availability, whilst ZnT1 and hZTL1/ZnT5 proteins are reduced under Zn-supplemented conditions [1].
  • Localisation of hZTL1/ZnT5 at the apical membrane of the placental syncytiotrophoblast indicates a fundamental role in the transfer of Slc30 Zn to the foetus [1].
  • Heterologous expression of hZTL1 in Xenopus laevis oocytes increased zinc uptake across the plasma membrane [6].
  • In the human pancreas, hZnT-5 was expressed abundantly in insulin-containing beta cells that contain zinc at the highest level in the body [10].
 

Other interactions of SLC30A5

 

Analytical, diagnostic and therapeutic context of SLC30A5

References

  1. Intestinal and placental zinc transport pathways. Ford, D. The Proceedings of the Nutrition Society. (2004) [Pubmed]
  2. Osteopenia and male-specific sudden cardiac death in mice lacking a zinc transporter gene, Znt5. Inoue, K., Matsuda, K., Itoh, M., Kawaguchi, H., Tomoike, H., Aoyagi, T., Nagai, R., Hori, M., Nakamura, Y., Tanaka, T. Hum. Mol. Genet. (2002) [Pubmed]
  3. Zinc transport complexes contribute to the homeostatic maintenance of secretory pathway function in vertebrate cells. Ishihara, K., Yamazaki, T., Ishida, Y., Suzuki, T., Oda, K., Nagao, M., Yamaguchi-Iwai, Y., Kambe, T. J. Biol. Chem. (2006) [Pubmed]
  4. Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatases in vertebrate cells. Suzuki, T., Ishihara, K., Migaki, H., Ishihara, K., Nagao, M., Yamaguchi-Iwai, Y., Kambe, T. J. Biol. Chem. (2005) [Pubmed]
  5. Zinc transporters, ZnT5 and ZnT7, are required for the activation of alkaline phosphatases, zinc-requiring enzymes that are glycosylphosphatidylinositol-anchored to the cytoplasmic membrane. Suzuki, T., Ishihara, K., Migaki, H., Matsuura, W., Kohda, A., Okumura, K., Nagao, M., Yamaguchi-Iwai, Y., Kambe, T. J. Biol. Chem. (2005) [Pubmed]
  6. A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane. Cragg, R.A., Christie, G.R., Phillips, S.R., Russi, R.M., Küry, S., Mathers, J.C., Taylor, P.M., Ford, D. J. Biol. Chem. (2002) [Pubmed]
  7. A new locus for nonsyndromic deafness DFNB49 maps to chromosome 5q12.3-q14.1. Ramzan, K., Shaikh, R.S., Ahmad, J., Khan, S.N., Riazuddin, S., Ahmed, Z.M., Friedman, T.B., Wilcox, E.R., Riazuddin, S. Hum. Genet. (2005) [Pubmed]
  8. Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study. Devergnas, S., Chimienti, F., Naud, N., Pennequin, A., Coquerel, Y., Chantegrel, J., Favier, A., Seve, M. Biochem. Pharmacol. (2004) [Pubmed]
  9. Homeostatic regulation of zinc transporters in the human small intestine by dietary zinc supplementation. Cragg, R.A., Phillips, S.R., Piper, J.M., Varma, J.S., Campbell, F.C., Mathers, J.C., Ford, D. Gut (2005) [Pubmed]
  10. Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells. Kambe, T., Narita, H., Yamaguchi-Iwai, Y., Hirose, J., Amano, T., Sugiura, N., Sasaki, R., Mori, K., Iwanaga, T., Nagao, M. J. Biol. Chem. (2002) [Pubmed]
  11. Regulation of zinc metabolism and genomic outcomes. Cousins, R.J., Blanchard, R.K., Moore, J.B., Cui, L., Green, C.L., Liuzzi, J.P., Cao, J., Bobo, J.A. J. Nutr. (2003) [Pubmed]
 
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