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Gene Review:

Bpifa5 - BPI fold containing family A, member 5

Mus musculus

Synonyms: 2310021H06Rik, 2310074B19Rik, BPI fold-containing family A member 5, BPI fold-containing family A member Pluncl, Palate lung and nasal carcinoma-like protein, ...

Park, J.H. et al., Gariboldi, M.B. et al., McCarron, R.M. et al., Wang, H. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of 2310021H06Rik

Our findings suggest a potential use for TPL as a novel antiproliferative agent for the treatment of malignant gliomas [1].
When C6 cells were grown as xenografts in nude mice, treatment with TPL induced a significant dose-dependent decrease in tumour growth, without signs of general or organ toxicity [1].
Also, this study tested the protection produced by PNS/TPL in a mouse model of trinitrobenzene sulfonic acid (TNBS)-induced colitis [2].
PNS/TPL protected against cachexia and mortality, both usually induced by TNBS [2].
This study examines: 1) the possible 2-AG modulation of BBB injury and edema formation induced by closed head injury (CHI); and 2) comparable effects between 2-AG and 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (TPL), a known antioxidant nitroxide on endothelial Ca2+ and cytoskeletal responses to H2O2 (ROS) [3].

High impact information on 2310021H06Rik

The application of gold nanorods as TPL imaging agents is demonstrated by in vivo imaging of single nanorods flowing in mouse ear blood vessels [4].
The TPL signal from a single nanorod is 58 times that of the two-photon fluorescence signal from a single rhodamine molecule [4].
Morphological features of apoptosis were apparent in C6 cells following in vitro treatment with TPL [1].
Here, the antioxidant capacity and protective effects of a new class of chemically modified hetastarch (polynitroxyl starch, or PNS) plus 4-hydroxyl-2,2,6,6-tetramethylpiperidine-N-oxyl (Tempol or TPL) (PNS/TPL) were assessed in a model of colitis [2].
The effects of PNS/TPL on X/XO-induced neutrophil endothelial adhesion in vitro were investigated [2].

Chemical compound and disease context of 2310021H06Rik

Here, we show that Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl; TPL), a stable nitroxide free radical, inhibits the growth of C6 glioma cells both in vitro and in vivo [1].

Anatomical context of 2310021H06Rik

In conclusion, PNS/TPL may be beneficial in the treatment or prevention of IBD through its antioxidant effects, which inhibit oxidant-mediated leukocyte adhesion and injury to endothelial cells [2].
The endothelial H2O2-stimulated Ca2+ mobilization and cytoskeleton (vimentin) rearrangement was modified by either 2-AG or TPL [3].

References

Study of in vitro and in vivo effects of the piperidine nitroxide Tempol--a potential new therapeutic agent for gliomas. Gariboldi, M.B., Ravizza, R., Petterino, C., Castagnaro, M., Finocchiaro, G., Monti, E. Eur. J. Cancer (2003) [Pubmed]
Polynitroxylated starch/TPL attenuates cachexia and increased epithelial permeability associated with TNBS colitis. Park, J.H., Ma, L., Oshima, T., Carter, P., Coe, L., Ma, J.W., Specian, R., Grisham, M.B., Trimble, C.E., Hsia, C.J., Liu, J.E., Alexander, J.S. Inflammation (2002) [Pubmed]
Antioxidant properties of the vasoactive endocannabinoid, 2-arachidonoyl glycerol (2-AG). McCarron, R.M., Shohami, E., Panikashvili, D., Chen, Y., Golech, S., Strasser, A., Mechoulam, R., Spatz, M. Acta Neurochir. Suppl. (2003) [Pubmed]
In vitro and in vivo two-photon luminescence imaging of single gold nanorods. Wang, H., Huff, T.B., Zweifel, D.A., He, W., Low, P.S., Wei, A., Cheng, J.X. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]

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