Gene Review:
TOP3A - topoisomerase (DNA) III alpha
Homo sapiens
Synonyms:
DNA topoisomerase 3-alpha, DNA topoisomerase III alpha, TOP3, ZGRF7
- Cloning and characterization of the 5'-flanking region for the human topoisomerase III gene. Kim, J.C., Yoon, J.B., Koo, H.S., Chung, I.K. J. Biol. Chem. (1998)
- Overexpression of a truncated human topoisomerase III partially corrects multiple aspects of the ataxia-telangiectasia phenotype. Fritz, E., Elsea, S.H., Patel, P.I., Meyn, M.S. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Human TOP3: a single-copy gene encoding DNA topoisomerase III. Hanai, R., Caron, P.R., Wang, J.C. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Sgs1 regulates gene conversion tract lengths and crossovers independently of its helicase activity. Lo, Y.C., Paffett, K.S., Amit, O., Clikeman, J.A., Sterk, R., Brenneman, M.A., Nickoloff, J.A. Mol. Cell. Biol. (2006)
- Top3 processes recombination intermediates and modulates checkpoint activity after DNA damage. Mankouri, H.W., Hickson, I.D. Mol. Biol. Cell (2006)
- Gene for topoisomerase III maps within the Smith-Magenis syndrome critical region: analysis of cell-cycle distribution and radiation sensitivity. Elsea, S.H., Fritz, E., Schoener-Scott, R., Meyn, M.S., Patel, P.I. Am. J. Med. Genet. (1998)
- Diversity of DNA topoisomerases I and inhibitors. Pommier, Y. Biochimie (1998)
- Isolation of a cDNA encoding mouse DNA topoisomerase III which is highly expressed at the mRNA level in the testis. Seki, T., Seki, M., Katada, T., Enomoto, T. Biochim. Biophys. Acta (1998)
- Amplification of 17p11.2 approximately p12, including PMP22, TOP3A, and MAPK7, in high-grade osteosarcoma. van Dartel, M., Cornelissen, P.W., Redeker, S., Tarkkanen, M., Knuutila, S., Hogendoorn, P.C., Westerveld, A., Gomes, I., Bras, J., Hulsebos, T.J. Cancer Genet. Cytogenet. (2002)
- Cell type-dependent regulation of human DNA topoisomerase III alpha gene expression by upstream stimulatory factor 2. Han, S.Y., Kim, J.C., Suh, J.M., Chung, I.K. FEBS Lett. (2001)
- Optical imaging of tumor hypoxia and evaluation of efficacy of a hypoxia-targeting drug in living animals. Harada, H., Kizaka-Kondoh, S., Hiraoka, M. Molecular imaging : official journal of the Society for Molecular Imaging. (2005)