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CACNA1E  -  calcium channel, voltage-dependent, R type...

Homo sapiens

Synonyms: BII, Brain calcium channel II, CACH6, CACNL1A6, Cav2.3, ...
 
 
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Disease relevance of CACNA1E

  • Five milligrams per kilogram of pentobarbital was administered to groups AII and BII; 10 mg/kg in groups AIII, BIII, and BVI; 20 mg/kg in group BIV; and none in groups AI, BI, and BV [1].
  • RT-PCR and Western blot analyses of blast cell protein lysates suggest that approximately 50% of BII leukemias overexpress Ikaros 6 RNA and protein [2].
  • With increasing severity of inflammation, the IgG2-cell proportion was significantly increased from 4-6% to 26-34% in simple and BII gastritis, whereas the ratio of IgG1 immunocytes was correspondingly decreased from 58-69% to 38-43% [3].
  • Four symptomatic patients with medically intractable ARG and chronic gastroparesis had subtotal BII gastric resection with BEE rather than Roux-en-Y diversion [4].
  • In this study the proportions of IgG1-, IgG2-, IgG3-, and IgG4-producing immunocytes were determined by paired immunofluorescence staining in specimens from simple gastritis, gastritis after Billroth II (BII) resection, and gastritis associated with dermatitis herpetiformis (DH) [3].
 

Psychiatry related information on CACNA1E

  • The empirical literature that pertains to phobias of blood, injury, or illness (BII) is surveyed [5].
  • The present study was carried out to explore the relation between BII phobia and dental phobia [6].
  • In the current case report, we describe the treatment of BIIP in a young man with mental retardation [7].
 

High impact information on CACNA1E

  • Pancreatic and biliary secretion and gastric emptying rates of a liquid test meal (LTM) were determined in normal persons, in patients with subtotal gastrectomy with gastroduodenostomy (STG-BI) or with gastrojejunostomy (STG-BII), and in patients with truncal vagotomy and pyloroplasty (V&P) [8].
  • The G.G base pairing induces high-BII phosphate conformations at residues G-9 and T-20 in addition to more normal BII conformations at G-10 and G-22 [9].
  • When cytosine is the 5' neighbor, the helix adopts a mostly BII conformation, whereas a 5' guanine preserves the canonical BI [10].
  • More generally, it is also found that the base sequence and hence the backbone geometry of a DNA segment, strongly influences both the conformational impact of the transition, the associated energy barrier and the stability of the resulting BII state [11].
  • Amplification and Overexpression of CACNA1E Correlates with Relapse in Favorable Histology Wilms' Tumors [12].
 

Chemical compound and disease context of CACNA1E

  • These results indicate that the patients with borderline diabetes BI as well as BII, are closely related with diabetes mellitus, and that the patients with impaired glucose tolerance should be treated with diet restriction as in diabetes mellitus [13].
 

Biological context of CACNA1E

 

Anatomical context of CACNA1E

  • Human retinal pigment epithelial cells express scavenger receptors BI and BII [18].
  • Comparison of BII cells with high or normal levels of Ik6 shows a higher level of expression for the membrane stem cell antigen CD34 in the former, as detected with flow cytometry and confirmed with DNA arrays [2].
  • Altogether these data provide definitive evidence that BII represents a human cell line of different origin than HL-60 [19].
  • Our low-temperature experiments show that native B-DNA from salmon testes and the d(CGCGAATTCGCG)2 dodecamer have the same BI and BII substates [20].
  • 3. Antibodies against rat Cav1.2 and Cav2.3 channels differentially label proteins in the flagella and acrosome of mature sea urchin sperm [21].
 

Associations of CACNA1E with chemical compounds

  • Itraconazole appears useful as a corticosteroid sparing agent (BII) [22].
  • In BI patients the increase in blood glucose was similar to that in normal subjects, but the response was significantly greater in BII and TG patients [23].
  • In contrast, SNX-482 (100 nm), a selective antagonist of R-type calcium channels containing the alpha1E (Cav2.3) subunit, attenuated carbachol inhibition of the somatic spike-evoked calcium transient [24].
  • The methanol solution structure of tricholongins BI and BII has been investigated using both one- and two-dimensional NMR techniques [25].
  • A single dose of genistein did not offer any protection (EII vs BII, p = NS), nor did it modify the preconditioning effect (EI vs BI, p = NS) [26].
 

Other interactions of CACNA1E

  • To determine more detailed locations of human P/Q-type (alpha 1A), N-type (alpha 1B), and R-type (alpha 1E) calcium channel genes, we have mapped CACNL1A4 (alpha 1A), CACNL1A5 (alpha 1B), and CACNL1A6 (alpha 1E) loci using a radiation hybrid panel [27].
  • Primary cultures of human RPE cells express both mRNA and protein for SR-BI and SR- BII [18].
  • Furthermore, COX-2 levels were higher after BII than after BI anastomosis [28].
  • Muscarinic modulation of Cav2.3 (R-type) calcium channels is antagonized by RGS3 and RGS3T [29].
 

Analytical, diagnostic and therapeutic context of CACNA1E

References

  1. Protection of the spinal cord with pentobarbital and hypothermia. Kazama, S., Miyoshi, Y., Nie, M., Imai, H., Lin, Z.B., Kurata, A., Machii, M. Ann. Thorac. Surg. (2001) [Pubmed]
  2. Overexpression of dominant-negative Ikaros 6 protein is restricted to a subset of B common adult acute lymphoblastic leukemias that express high levels of the CD34 antigen. Tonnelle, C., Imbert, M.C., Sainty, D., Granjeaud, S., N'Guyen, C., Chabannon, C. Hematol. J. (2003) [Pubmed]
  3. Subclass distribution of mucosal IgG-producing cells in gastritis. Valnes, K., Brandtzaeg, P. Gut (1989) [Pubmed]
  4. Clinical and radionuclide evaluation of bile diversion by Braun enteroenterostomy: prevention and treatment of alkaline reflux gastritis. An alternative to Roux-en-Y diversion. Vogel, S.B., Drane, W.E., Woodward, E.R. Ann. Surg. (1994) [Pubmed]
  5. Blood-injury-illness phobia: a review. Thyer, B.A., Himle, J., Curtis, G.C. Journal of clinical psychology. (1985) [Pubmed]
  6. Blood-injury-injection phobia and dental phobia. De Jongh, A., Bongaarts, G., Vermeule, I., Visser, K., De Vos, P., Makkes, P. Behaviour research and therapy. (1998) [Pubmed]
  7. Multicomponent treatment for blood-injury-injection phobia in a young man with mental retardation. Hagopian, L.P., Crockett, J.L., Keeney, K.M. Research in developmental disabilities. (2001) [Pubmed]
  8. Gastric emptying of liquid meals and pancreatic and biliary secretion after subtotal gastrectomy or truncal vagotomy and pyloroplasty in man. MacGregor, I., Parent, J., Meyer, J.H. Gastroenterology (1977) [Pubmed]
  9. Crystal structure of an oligonucleotide duplex containing G.G base pairs: influence of mispairing on DNA backbone conformation. Skelly, J.V., Edwards, K.J., Jenkins, T.C., Neidle, S. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  10. The relationship between mutation rates for the (C-G)-->(T-A) transition and features of T-G mispair structures in different neighbor environments, determined by free energy molecular mechanics. Mitra, R., Pettitt, B.M., Ramé, G.L., Blake, R.D. Nucleic Acids Res. (1993) [Pubmed]
  11. BI-BII transitions in B-DNA. Hartmann, B., Piazzola, D., Lavery, R. Nucleic Acids Res. (1993) [Pubmed]
  12. Amplification and Overexpression of CACNA1E Correlates with Relapse in Favorable Histology Wilms' Tumors. Natrajan, R., Little, S.E., Reis-Filho, J.S., Hing, L., Messahel, B., Grundy, P.E., Dome, J.S., Schneider, T., Vujanic, G.M., Pritchard-Jones, K., Jones, C. Clin. Cancer Res. (2006) [Pubmed]
  13. Evaluation of new criteria for diagnosis of diabetes mellitus based on follow-up study of borderline diabetes. Ohneda, A., Kobayashi, T., Nihei, J. Tohoku J. Exp. Med. (1982) [Pubmed]
  14. Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits. Diriong, S., Lory, P., Williams, M.E., Ellis, S.B., Harpold, M.M., Taviaux, S. Genomics (1995) [Pubmed]
  15. Molecular analysis and functional expression of the human type E neuronal Ca2+ channel alpha 1 subunit. Schneider, T., Wei, X., Olcese, R., Costantin, J.L., Neely, A., Palade, P., Perez-Reyes, E., Qin, N., Zhou, J., Crawford, G.D. Recept. Channels (1994) [Pubmed]
  16. DNA-binding proteins for transcription enhancing region of HLA class I gene. Park, J.H., Lee, H.W., Fleischhauer, K.L., Kim, C.G., Sheffery, M., Yang, S.Y. Tissue Antigens (1993) [Pubmed]
  17. Screening of a peanut (Arachis hypogaea L.) cDNA library to isolate a Bowman-Birk trypsin inhibitor clone. Boateng, J.A., Viquez, O.M., Konan, K.N., Dodo, H.W. J. Agric. Food Chem. (2005) [Pubmed]
  18. Human retinal pigment epithelial cells express scavenger receptors BI and BII. Duncan, K.G., Bailey, K.R., Kane, J.P., Schwartz, D.M. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  19. Southern blot analysis of BII cell line--a putative variant of HL-60. Band, H., Corredor, V., Lustgarten, J., Huebner, K., Griffin, J.D., Kufe, D.W., Yunis, E.J. Leukemia (1987) [Pubmed]
  20. Unexpected BII conformer substate population in unoriented hydrated films of the d(CGCGAATTCGCG)2 dodecamer and of native B-DNA from salmon testes. Pichler, A., Rüdisser, S., Mitterböck, M., Huber, C.G., Winger, R.H., Liedl, K.R., Hallbrucker, A., Mayer, E. Biophys. J. (1999) [Pubmed]
  21. Identification of voltage-dependent Ca2+ channels in sea urchin sperm. Granados-Gonzalez, G., Mendoza-Lujambio, I., Rodriguez, E., Galindo, B.E., Beltrán, C., Darszon, A. FEBS Lett. (2005) [Pubmed]
  22. Practice guidelines for diseases caused by Aspergillus. Infectious Diseases Society of America. Stevens, D.A., Kan, V.L., Judson, M.A., Morrison, V.A., Dummer, S., Denning, D.W., Bennett, J.E., Walsh, T.J., Patterson, T.F., Pankey, G.A. Clin. Infect. Dis. (2000) [Pubmed]
  23. The role of endogenous gastric inhibitory polypeptide in the enteroinsular axis. Takemura, J., Seino, Y., Yamamura, T., Tsuda, K., Seino, S., Itoh, N., Imura, H. J. Clin. Endocrinol. Metab. (1982) [Pubmed]
  24. Transmitter modulation of spike-evoked calcium transients in arousal related neurons: muscarinic inhibition of SNX-482-sensitive calcium influx. Kohlmeier, K.A., Leonard, C.S. Eur. J. Neurosci. (2006) [Pubmed]
  25. Tricholongins BI and BII, 19-residue peptaibols from Trichoderma longibrachiatum. Solution structure from two-dimensional NMR spectroscopy. Rebuffat, S., Prigent, Y., Auvin-Guette, C., Bodo, B. Eur. J. Biochem. (1991) [Pubmed]
  26. The effect of the phytoestrogen genistein on myocardial protection, preconditioning and oxidative stress. Sbarouni, E., Iliodromitis, E.K., Zoga, A., Vlachou, G., Andreadou, I., Kremastinos, D.T. Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy (2006) [Pubmed]
  27. Locations of human genes for alpha 1A, alpha 1B, and alpha 1E calcium channels determined by radiation hybrid mapping. Yamazaki, K., Oki, T., Tanaka, I. J. Hered. (1998) [Pubmed]
  28. Interleukin-8, cyclo-oxygenase-2, and trefoil factor family 1 gene expression and their association with Helicobacter pylori infection in the remnant stomach. Xing, C., Kato, S., Matsukura, N., Matsuda, N., Xu, H., Takashi, E., Yamada, N., Naito, Z., Tajiri, T. Surgery today. (2005) [Pubmed]
  29. Muscarinic modulation of Cav2.3 (R-type) calcium channels is antagonized by RGS3 and RGS3T. Toro-Castillo, C., Thapliyal, A., Gonzalez-Ochoa, H., Adams, B.A., Meza, U. Am. J. Physiol., Cell Physiol. (2007) [Pubmed]
  30. Characterization of the promoter of human leukocyte-specific transcript 1. A small gene with a complex pattern of alternative transcripts. Yu, X., Weissman, S.M. J. Biol. Chem. (2000) [Pubmed]
 
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