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PDA1  -  pyruvate dehydrogenase (acetyl...

Saccharomyces cerevisiae S288c

Synonyms: PDHE1-A, Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial, Pyruvate dehydrogenase complex component E1 alpha, YER178W
 
 
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High impact information on PDA1

 

Biological context of PDA1

 

Associations of PDA1 with chemical compounds

  • The co-disruption of ALD4 and PDA1 (encoding subunit E1alpha of pyruvate dehydrogenase) prevented the growth on pyruvate for both strains but prevented growth on lactate only in the double mutant derived from the YPH499 strain, indicating that the mutation effects are strain-dependent [8].
  • Expression of PDA1 and activity of the PDH complex were also detected in cultures grown under conditions where no physiological significance of the PDH complex was expected, i.e. during anaerobic growth on glucose or aerobic growth on ethanol [9].
  • Induction of the regulatory GCN4 mechanism upon histidine starvation, using the anti-metabolite 3-amino-1,2,4-triazole, increased the levels of PDA1 mRNA by approximately 40% [9].
  • A wild-type specific growth rate was restored after introduction of an intact KlPDA1 gene but not, as previously found for S. cerevisiae pda1 mutants, by cultivation in the presence of leucine [6].
 

Physical interactions of PDA1

  • Computer analysis revealed a putative GCN4 binding motif in the PDA1 promoter [4].
 

Other interactions of PDA1

  • Consistent with this, the PDA1 gene was genetically mapped at 4 cM from RAD3 [4].
  • Hence, expression of the PDA1 gene is only regulated to a small extent, if at all, by the GCN4 mechanism [9].

References

  1. A mitochondrial pyruvate dehydrogenase bypass in the yeast Saccharomyces cerevisiae. Boubekeur, S., Bunoust, O., Camougrand, N., Castroviejo, M., Rigoulet, M., Guérin, B. J. Biol. Chem. (1999) [Pubmed]
  2. A binuclear zinc transcription factor binds the host isoflavonoid-responsive element in a fungal cytochrome p450 gene responsible for detoxification. Khan, R., Tan, R., Mariscal, A.G., Straney, D. Mol. Microbiol. (2003) [Pubmed]
  3. PDA1 mRNA: a standard for quantitation of mRNA in Saccharomyces cerevisiae superior to ACT1 mRNA. Wenzel, T.J., Teunissen, A.W., de Steensma, H.Y. Nucleic Acids Res. (1995) [Pubmed]
  4. Promoter analysis of the PDA1 gene encoding the E1 alpha subunit of the pyruvate dehydrogenase complex from Saccharomyces cerevisiae. Wenzel, T.J., Zuurmond, A.M., Bergmans, A., van den Berg, J.A., Steensma, H.Y. Yeast (1994) [Pubmed]
  5. Characterization of Saccharomyces cerevisiae mutants lacking the E1 alpha subunit of the pyruvate dehydrogenase complex. Wenzel, T.J., van den Berg, M.A., Visser, W., van den Berg, J.A., Steensma, H.Y. Eur. J. Biochem. (1992) [Pubmed]
  6. Inactivation of the Kluyveromyces lactis KlPDA1 gene leads to loss of pyruvate dehydrogenase activity, impairs growth on glucose and triggers aerobic alcoholic fermentation. Zeeman, A.M., Luttik, M.A., Thiele, C., van Dijken, J.P., Pronk, J.T., Steensma, H.Y. Microbiology (Reading, Engl.) (1998) [Pubmed]
  7. Expression of the yeast calcineurin subunits CNA1 and CNA2 during growth and hyper-osmotic stress. Del Aguila, E.M., Silva, J.T., Paschoalin, V.M. FEMS Microbiol. Lett. (2003) [Pubmed]
  8. Participation of acetaldehyde dehydrogenases in ethanol and pyruvate metabolism of the yeast Saccharomyces cerevisiae. Boubekeur, S., Camougrand, N., Bunoust, O., Rigoulet, M., Guérin, B. Eur. J. Biochem. (2001) [Pubmed]
  9. Regulation of the PDA1 gene encoding the E1 alpha subunit of the pyruvate dehydrogenase complex from Saccharomyces cerevisiae. Wenzel, T.J., Luttik, M.A., van den Berg, J.A., de Steensma, H.Y. Eur. J. Biochem. (1993) [Pubmed]
 
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