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Gene Review

CDY1  -  chromodomain protein, Y-linked, 1

Homo sapiens

Synonyms: CDY, CDY1A
 
 
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Disease relevance of CDY1

 

High impact information on CDY1

  • Taken together, these data link human CDY and mouse CDYL to the histone-to-protamine transition in mammalian spermiogenesis [3].
  • Here, we characterize the CDY-related mammalian gene family, focusing on three aspects of its evolution: gene copy number, tissue expression profile and amino acid sequence [4].
  • Six of these loci (including three apparent pseudogenes, a novel HP1 ortholog, and two novel Msl-3 transcription factor-like proteins) are not present in the human genome, whereas the human genome contains four loci (two CDY orthologs and two apparent CDY pseudogenes) that are not present in mouse [5].
  • CDY2 was expressed whenever germ cells were present, but CDY1 major and especially CDY1 minor and short transcripts were identified almost exclusively when mature spermatids/spermatozoa were detected [6].
  • However, in consideration of the high levels of identity between CDY1 and CDY2 (98% at the protein level), the delayed up-regulation of CDY1 transcripts could be attributable to temporal changes in dosage requirements [6].
 

Biological context of CDY1

  • It is suggested that CDY2 is apparently required in the early stages of spermatogenesis, whereas CDY1 transcripts are required later on in the process [6].
  • A previously unreported CDY1-minor alternative splicing transcript was identified [7].
  • Therefore, there was no clear relation between genotype and phenotype, and the loss of the distal copy of CDY1 does not seem to worsen the phenotype of infertile patients with deletion of the DAZ gene cluster [8].
  • The CDY family of genes is of special interest because some of them are included in chromosome-Y microdeletions detected among infertile men and are apparently involved in the spermiogenetic process [6].
 

Anatomical context of CDY1

  • RESULT(S): CDY1-minor expression was detected in all biopsies in which mature spermatids/spermatozoa were observed by histological analysis and/or in the minced tissue [7].
 

Other interactions of CDY1

  • RESULTS: Complete AZFc deletions, including BPY2, CDY1 and DAZ genes, were identified in 24 men [9].

References

  1. Transmission of a Y chromosomal deletion involving the deleted in azoospermia (DAZ) and chromodomain (CDY1) genes from father to son through intracytoplasmic sperm injection: case report. Kamischke, A., Gromoll, J., Simoni, M., Behre, H.M., Nieschlag, E. Hum. Reprod. (1999) [Pubmed]
  2. DNA methylation regulates the expression of Y chromosome specific genes in prostate cancer. Dasari, V.K., Deng, D., Perinchery, G., Yeh, C.C., Dahiya, R. J. Urol. (2002) [Pubmed]
  3. Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis. Lahn, B.T., Tang, Z.L., Zhou, J., Barndt, R.J., Parvinen, M., Allis, C.D., Page, D.C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  4. The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence. Dorus, S., Gilbert, S.L., Forster, M.L., Barndt, R.J., Lahn, B.T. Hum. Mol. Genet. (2003) [Pubmed]
  5. Identification and analysis of chromodomain-containing proteins encoded in the mouse transcriptome. Tajul-Arifin, K., Teasdale, R., Ravasi, T., Hume, D.A., Mattick, J.S. Genome Res. (2003) [Pubmed]
  6. Members of the CDY family have different expression patterns: CDY1 transcripts have the best correlation with complete spermatogenesis. Kleiman, S.E., Yogev, L., Hauser, R., Botchan, A., Bar-Shira Maymon, B., Schreiber, L., Paz, G., Yavetz, H. Hum. Genet. (2003) [Pubmed]
  7. Expression of CDY1 may identify complete spermatogenesis. Kleiman, S.E., Lagziel, A., Yogev, L., Botchan, A., Paz, G., Yavetz, H. Fertil. Steril. (2001) [Pubmed]
  8. CDY1 analysis in infertile patients with DAZ deletions. Ferlin, A., Moro, E., Rossi, A., Foresta, C. J. Endocrinol. Invest. (2001) [Pubmed]
  9. Uniform deletion junctions of complete azoospermia factor region c deletion in infertile men in Taiwan. Hsu, C.C., Kuo, P.L., Chuang, L., Lin, Y.H., Teng, Y.N., Lin, Y.M. Asian J. Androl. (2006) [Pubmed]
 
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