Association of allergic contact dermatitis with a promoter polymorphism in the IL16 gene.
BACKGROUND: There is evidence that IL-16, a cytokine that induces chemotactic responses in CD4(+) T cells, eosinophils, and dendritic cells, plays an important role during different types of cutaneous inflammatory responses, including allergic contact dermatitis (ACD) and atopic dermatitis (AD). OBJECTIVES: We sought to test for association between a promoter polymorphism in the IL16 gene (T to C transition at position -295) and ACD and AD, respectively. METHODS: IL16 -295 genotypes were determined in samples from 2 separate case-control studies with white individuals. The first study included healthy individuals (n = 310) and patients with ACD (n = 86). These patients were polysensitized as defined by a contact sensitization to para-substituted aryl compounds and at least one other structurally unrelated allergen. The second study comprised healthy subjects (n = 214) and patients with AD (n = 94). RESULTS: IL16 -295 genotypes were differently distributed among polysensitized and healthy control subjects (P =.0021). In particular, the IL16 -295*C/C genotype was overrepresented among polysensitized individuals (7.0% vs 1.0% in the control group; odds ratio, 7.68; 95% CI, 1.59-48.12). In contrast, there was no evidence for an association between the IL16 -295 polymorphism and AD. CONCLUSION: The IL16 -295 promoter polymorphism might influence susceptibility to contact allergy.[1]References
- Association of allergic contact dermatitis with a promoter polymorphism in the IL16 gene. Reich, K., Westphal, G., König, I.R., Mössner, R., Krüger, U., Ziegler, A., Neumann, C., Schnuch, A. J. Allergy Clin. Immunol. (2003) [Pubmed]
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