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Aloeresin I, an anti-inflammatory 5-methylchromone from cape aloe.

A new diglucoside having a 5-methylchromone moiety was isolated from a commercial sample of Cape aloe, the dried exudate from Aloe ferox Miller, and named aloeresin I. Its structure was established as 1 on the basis of spectral and chemical evidence. Aloeresin I (1) (1 micromol/cm2) reduces in vivo the oedematous response (39 %) induced by Croton oil in the mouse ear with the same potency as aloesin, one of the most abundant Cape aloe constituents, and to a higher extent than aloeresin H (2). Indomethacin (0.3 micromol/cm2), the reference anti-inflammatory compound, provokes 61 % oedema inhibition.[1]

References

  1. Aloeresin I, an anti-inflammatory 5-methylchromone from cape aloe. Speranza, G., Morelli, C.F., Tubaro, A., Altinier, G., Durì, L., Manitto, P. Planta Med. (2005) [Pubmed]
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