- Increased CDA expression/activity in males contributes to decreased cytidine analog half-life and likely contributes to worse outcomes with 5-azacytidine or decitabine therapy. Mahfouz, R.Z., Jankowska, A., Ebrahem, Q., Gu, X., Visconte, V., Tabarroki, A., Terse, P., Covey, J., Chan, K., Ling, Y., Engelke, K.J., Sekeres, M.A., Tiu, R., Maciejewski, J., Radivoyevitch, T., Saunthararajah, Y. Clin. Cancer Res. (2013)