- Protein-tyrosine phosphatase activity regulates osteoclast formation and function: inhibition by alendronate. Schmidt, A., Rutledge, S.J., Endo, N., Opas, E.E., Tanaka, H., Wesolowski, G., Leu, C.T., Huang, Z., Ramachandaran, C., Rodan, S.B., Rodan, G.A. Proc. Natl. Acad. Sci. U.S.A. (1996)