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MeSH term: ... Disease relevance of Genes, BRCA2 CONCLUSION: These results suggest the possible contribution... gene( BRCA2) on 13q to parathyroid tumours in this family. High impact information on Genes, BRCA2 Cloning of a breast cancer- predisposing gene( BRCA2) on chromosome 13Q12- 14 has been reported recently... / Synonyms: BRCA2 Gene; BRCA2 Genes; Gene, BRCA2
Homo sapiens
Gene: ... predisposition -- often associated with the BRCA1 and BRCA2 genes -- in at least 5% to 10% of all epithelial...Disease relevance of BRCA2 Inheritance of one defective BRCA2 allele predisposes humans to breast cancer. Mutations in BRCA1 and BRCA2 confer a high risk of breast and ovarian cancer, but account...
Canis lupus familiaris
Gene: ... Disease relevance of BRCA2 Mutations in human Brca2 confer an increased risk of female breast cancer....
Felis catus
Gene: ... Disease relevance of Brca2 As mutations in human Brca2 confer an increased risk of breast cancer, the full- length cDNA of the feline homologue of Brca2 was sequenced to obtain a basis for studying the relationship between its function and susceptibility to mammary tumors. High impact information on Brca2...
Rattus norvegicus
Gene: ... High impact information on Brca2 However, no variation in Brca1 or Brca2 protein expression... and Brca2 tumor suppressor genes in mammary glands of female Wistar rats. Cloning of rat Brca2 and linkage mapping to chromosome 12. Analytical, diagnostic and therapeutic context of Brca2 Brca1 and Brca2 m...
Gallus gallus
Gene: ... Disease relevance of BRCA2 BRCA2 is a tumor suppressor gene that is linked to hereditary breast... breast cancer suppressor BRCA2/ FancD1, and Brip1/ FancJ helicase. High impact information on BRCA2... that Brca2 and the Rad51 paralogs may also contribute to HR at the same early step, with their loss...
Arabidopsis thaliana
Gene: Synonyms: BRCA2(V); BRCA2-like B
Mus musculus
Gene: ... the phenotype of Brca2 null embryos is more uniform, and they all survive for at least 8. 5 embryonic days...Disease relevance of Brca2 Mouse model for Brca2 mutation shows growth retardation and paradoxical occurrence of thymic lymphomas. These findings define a function of Brca2 in DNA repair, whose loss...
MeSH term: ... in the risk of breast cancer between carriers of BRCA1 mutations and carriers of BRCA2 mutations... in the 5' portion of the gene, but is inhibited by 3' BRCA1 mutations. A single BRCA2 mutation in male... susceptibility gene, BRCA2 on chromosome 13q12- 13, was recently isolated. Germline mutations of the human BRCA2...
Homo sapiens
Gene: ... impact information on BCCIP The BRCA2- interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair. These data indicate that BCCIP is critical for BRCA2.... Co- localisations of BCCIP We further show that chromatin- bound BRCA2 colocalizes with BCCIP nuclear... / Synonyms: BRCA2 and CDKN1A-interacting protein


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