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Gene Review:

BCCIP - BRCA2 and CDKN1A interacting protein

Homo sapiens

Synonyms: BCCIPalpha, BRCA2 and CDKN1A-interacting protein, P21-and CDK-associated protein 1, Protein TOK-1, TOK-1, ...

Meng, X. et al., Liu, J. et al., Lu, H. et al., Meng, X. et al., Meng, X. et al., et al.

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Disease relevance of BCCIP

Furthermore, expression of BCCIPalpha inhibits breast and brain cancer cell growth, but fails to inhibit HT1080 cells and a non-transformed human skin fibroblast [1].

High impact information on BCCIP

The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair [2].
These data indicate that BCCIP is critical for BRCA2- and RAD51-dependent responses to DNA damage and HRR [2].
Abrogation of the transactivation activity of p53 by BCCIP down-regulation [3].
The N-terminal half of the human BCCIP ICD shares moderate homology with regions of calmodulin and M-calpain, suggesting that BCCIP may also bind Ca [1].
BCCIP is a nuclear protein highly expressed in testis [1].

Biological context of BCCIP

In this study, we report the genomic structure of the human BCCIP gene, which contains nine exons [4].
These data suggest BCCIP beta as a new regulator for the G1-S cell cycle progression and cell growth control [5].
Inhibition of G1 to S cell cycle progression by BCCIP beta [5].
Our previous studies have showed that overexpression of BCCIPalpha inhibits the growth of certain tumor cells [Oncogene 20 (2001) 336] [4].
Alternative splicing of the 3'-terminal exons produces two isoforms of BCCIP transcripts, BCCIPalpha and BCCIPbeta [4].

Anatomical context of BCCIP

Although BCCIPbeta expression is relatively consistent in cancer cells, the expression of BCCIPalpha varies in cancer cell lines [1].

Co-localisations of BCCIP

We further show that chromatin-bound BRCA2 colocalizes with BCCIP nuclear foci and that most radiation-induced RAD51 foci colocalize with BCCIP [2].

Regulatory relationships of BCCIP

These data provide a new mechanism by which BCCIP regulates p21 functions [6].

Other interactions of BCCIP

Here we show that a second isoform, BCCIP beta, also binds to p21 and inhibits cell growth [5].

Analytical, diagnostic and therapeutic context of BCCIP

Using a matched normal/tumor cDNA array, we identified a reduced expression of BCCIP in kidney tumor, suggesting a role of BCCIP in cancer etiology [4].

References

Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2. Liu, J., Yuan, Y., Huan, J., Shen, Z. Oncogene (2001) [Pubmed]
The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair. Lu, H., Guo, X., Meng, X., Liu, J., Allen, C., Wray, J., Nickoloff, J.A., Shen, Z. Mol. Cell. Biol. (2005) [Pubmed]
Abrogation of the transactivation activity of p53 by BCCIP down-regulation. Meng, X., Yue, J., Liu, Z., Shen, Z. J. Biol. Chem. (2007) [Pubmed]
Genomic structure of the human BCCIP gene and its expression in cancer. Meng, X., Liu, J., Shen, Z. Gene (2003) [Pubmed]
Inhibition of G1 to S cell cycle progression by BCCIP beta. Meng, X., Liu, J., Shen, Z. Cell Cycle (2004) [Pubmed]
BCCIP functions through p53 to regulate the expression of p21Waf1/Cip1. Meng, X., Lu, H., Shen, Z. Cell Cycle (2004) [Pubmed]

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AgaP_AGAP003476	Anopheles gambiae str. PEST
BCCIP	Bos taurus
BCCIP	Canis lupus familiaris
bccip	Danio rerio
CG9286	Drosophila melanogaster
BCCIP	Gallus gallus
BCCIP	Macaca mulatta
Bccip	Mus musculus
BCCIP	Pan troglodytes
Bccip	Rattus norvegicus
bccip	Xenopus (Silurana) tropicalis

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