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Gene Review

BCCIP  -  BRCA2 and CDKN1A interacting protein

Homo sapiens

Synonyms: BCCIPalpha, BRCA2 and CDKN1A-interacting protein, P21-and CDK-associated protein 1, Protein TOK-1, TOK-1, ...
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Disease relevance of BCCIP


High impact information on BCCIP


Biological context of BCCIP


Anatomical context of BCCIP

  • Although BCCIPbeta expression is relatively consistent in cancer cells, the expression of BCCIPalpha varies in cancer cell lines [1].

Co-localisations of BCCIP

  • We further show that chromatin-bound BRCA2 colocalizes with BCCIP nuclear foci and that most radiation-induced RAD51 foci colocalize with BCCIP [2].

Regulatory relationships of BCCIP

  • These data provide a new mechanism by which BCCIP regulates p21 functions [6].

Other interactions of BCCIP


Analytical, diagnostic and therapeutic context of BCCIP

  • Using a matched normal/tumor cDNA array, we identified a reduced expression of BCCIP in kidney tumor, suggesting a role of BCCIP in cancer etiology [4].


  1. Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2. Liu, J., Yuan, Y., Huan, J., Shen, Z. Oncogene (2001) [Pubmed]
  2. The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair. Lu, H., Guo, X., Meng, X., Liu, J., Allen, C., Wray, J., Nickoloff, J.A., Shen, Z. Mol. Cell. Biol. (2005) [Pubmed]
  3. Abrogation of the transactivation activity of p53 by BCCIP down-regulation. Meng, X., Yue, J., Liu, Z., Shen, Z. J. Biol. Chem. (2007) [Pubmed]
  4. Genomic structure of the human BCCIP gene and its expression in cancer. Meng, X., Liu, J., Shen, Z. Gene (2003) [Pubmed]
  5. Inhibition of G1 to S cell cycle progression by BCCIP beta. Meng, X., Liu, J., Shen, Z. Cell Cycle (2004) [Pubmed]
  6. BCCIP functions through p53 to regulate the expression of p21Waf1/Cip1. Meng, X., Lu, H., Shen, Z. Cell Cycle (2004) [Pubmed]
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