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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Your search matched a total of 87 documents. Results 1 - 10.

Homo sapiens
Gene: ... Disease relevance of IRF3 In cells transiently expressing IRF7 or/ and IRF3, the VAF level... particle entry requires IRF3 but not virus replication. Furthermore, we demonstrate that HSV- 1 modifies the IRF3 pathway in a manner different from that of the small RNA viruses most commonly studied... / Synonyms: IRF-3
Mus musculus
Gene: ... Disease relevance of Irf3 The data suggest that pre- activated IRF- 3 is a major factor... that polyubiquitination of IRF- 3 increases in response to Sendai virus infection. Local delivery of murine recombinant IFN- beta protected C57BL/ 6 and IRF- 3 (-/-) mice against IVAG HSV- 2 challenge. The host response... / Synonyms: IRF-3
Bos taurus
Gene: ... Disease relevance of IRF3 Rotavirus non- structural protein NSP1 binds to and targets IRF3... protease N( pro) of BVDV appears to be, at least partly, responsible for suppressing IRF- 3 activation... involves a block to IRF- 3 function, and we speculate that this may be a key characteristic...
MeSH term: ... In unstimulated cells, IRF- 3 is present in an inactive cytoplasmic form; following Sendai virus infection, IRF- 3... and immunoblotting with a novel phosphospecific antibody, we show for the first time that, in vivo, IRF- 3... gene I( RIG- I ), a putative cellular RNA helicase. In cells transiently expressing IRF7 or/ and IRF3...
MeSH term: ... axis by membrane- bound TGF- beta. Competition with GR for GRIP1 antagonizes IRF3- mediated transcription, identifying the GRIP1: IRF3 interaction as a novel target for glucocorticoid immunosuppression...
Homo sapiens
Gene: ... and endothelial cells. Other interactions of TLR3 IRF3 mediates a TLR3/ TLR4- specific antiviral gene program. We demonstrate that, when the TLR3 pathway is stimulated, the levels of phosphorylated IRF3 are reduced... and illustrating that W protein- mediated inhibition is due to a loss of active IRF3. In contrast, enhanced CXCL11...
Homo sapiens
Gene: ... . IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. These include the kinase TBK1... and other DNA- associated immune disorders. We conclude that TBK1 is essential for IRF3- dependent antiviral... genomics: TBK1 and the IRF3 pathway. The protein kinase TBK1 is a key regulator inducing phosphorylation...
Macaca mulatta
Pan troglodytes
Canis lupus familiaris


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