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MeSH Review

Sendai virus

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Disease relevance of Sendai virus


High impact information on Sendai virus

  • Histamine release from rat mast cells induced by Sendai virus [6].
  • The expression of HPV16 E6 in primary human keratinocytes inhibits the induction of IFNbeta mRNA following Sendai virus infection [7].
  • These results imply that, if the cytotoxic T cell recognizes a single antigenic determinant specified both by viral and H-2 genes, this determinant is formed by the physical association of H-2 and Sendai virus antigens rather than by their alteration during the processes of synthesis [8].
  • Decades of research using Sendai-virus or polyethylene glycol (PEG)-mediated fusion in tissue culture showed that the terminally differentiated state of a cell could be altered [9].
  • In this study, we transferred angiotensin-converting enzyme (ACE) and/or renin cDNAs into cultured VSMC using the efficient Sendai virus (hemagglutinating virus of Japan) liposome-mediated gene transfer method, to examine their relative roles in VSMC growth in vitro [10].

Chemical compound and disease context of Sendai virus

  • Within 35 min or 6 h, the transfection of ACE cDNA into VSMC by hemagglutinating virus of Japan method resulted in a twofold higher ACE activity than control vector, whereas a cationic liposome (Lipofectin)-mediated method failed to show any effect [10].
  • Groups of pathogen-free F344 rats were treated with dexamethasone for 2 or 8 h (4 mg/kg i.p.) or 48 or 120 h (0.5-4 mg/kg per d i.p.). Another group of rats was treated with dexamethasone for 120 h following the intranasal inoculation of Sendai virus [11].
  • Primary tumor cells (MCT) induced in an inbred C3H mouse by 3-methylcholanthrene were fused with 8-azaguanine-resistant L-cells with the use of UV-irradiated HVJ (Sendai virus) [12].
  • A mixture of HVJ (Sendai virus) spike proteins, the nontoxic fragment A of diphtheria toxin, lecithin, and cholesterol was solubilized in sucrose solution containing a nonionic neutral detergent [13].
  • The Sendai virus (SeV) V protein is characterized by the unique cysteine-rich domain in its carboxy-terminal half which is fused to the amino-terminal half of the P protein, but its function has remained enigmatic [14].

Biological context of Sendai virus


Anatomical context of Sendai virus


Gene context of Sendai virus

  • Infection with Sendai virus led to expression of a similar set of cytokine genes and several of the IFNA genes [25].
  • Using SDS-PAGE and immunoblotting with a novel phosphospecific antibody, we show for the first time that, in vivo, IRF-3 is phosphorylated on Ser(396) following Sendai virus infection, expression of viral nucleocapsid, and double-stranded RNA treatment [26].
  • In contrast to poly(I-C), both cell types signal the presence of Sendai virus infection through a TLR3-independent intracellular pathway requiring expression of retinoic acid-inducible gene I (RIG-I), a putative cellular RNA helicase [27].
  • In cells transiently expressing IRF7 or/and IRF3, the VAF level and binding of VAF are clearly increased after Sendai virus infection [28].
  • METHODS: Sendai virus vector was used to express CCR2 molecules [29].

Analytical, diagnostic and therapeutic context of Sendai virus


  1. Sequence determination of the Sendai virus HN gene and its comparison to the influenza virus glycoproteins. Blumberg, B., Giorgi, C., Roux, L., Raju, R., Dowling, P., Chollet, A., Kolakofsky, D. Cell (1985) [Pubmed]
  2. Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides. Morishita, R., Gibbons, G.H., Ellison, K.E., Nakajima, M., von der Leyen, H., Zhang, L., Kaneda, Y., Ogihara, T., Dzau, V.J. J. Clin. Invest. (1994) [Pubmed]
  3. In vivo gene transfection with heat shock protein 70 enhances myocardial tolerance to ischemia-reperfusion injury in rat. Suzuki, K., Sawa, Y., Kaneda, Y., Ichikawa, H., Shirakura, R., Matsuda, H. J. Clin. Invest. (1997) [Pubmed]
  4. Sendai virus utilizes specific sialyloligosaccharides as host cell receptor determinants. Markwell, M.A., Paulson, J.C. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  5. Viral mutation accelerated by nitric oxide production during infection in vivo. Akaike, T., Fujii, S., Kato, A., Yoshitake, J., Miyamoto, Y., Sawa, T., Okamoto, S., Suga, M., Asakawa, M., Nagai, Y., Maeda, H. FASEB J. (2000) [Pubmed]
  6. Histamine release from rat mast cells induced by Sendai virus. Sugiyama, K. Nature (1977) [Pubmed]
  7. Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity. Ronco, L.V., Karpova, A.Y., Vidal, M., Howley, P.M. Genes Dev. (1998) [Pubmed]
  8. Joint recognition by cytotoxic T cells of inactivated Sendai virus and products of the major histocompatibility complex. Schrader, J.W., Edelman, G.M. J. Exp. Med. (1977) [Pubmed]
  9. Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant. Weimann, J.M., Johansson, C.B., Trejo, A., Blau, H.M. Nat. Cell Biol. (2003) [Pubmed]
  10. Novel and effective gene transfer technique for study of vascular renin angiotensin system. Morishita, R., Gibbons, G.H., Kaneda, Y., Ogihara, T., Dzau, V.J. J. Clin. Invest. (1993) [Pubmed]
  11. Glucocorticoids inhibit neurogenic plasma extravasation and prevent virus-potentiated extravasation in the rat trachea. Piedimonte, G., McDonald, D.M., Nadel, J.A. J. Clin. Invest. (1990) [Pubmed]
  12. Induced resistance in normal mice and growth enhancement in tumor-bearing mice by inoculation with syngeneic hybrid cells. Dei, T., Tachibana, T. J. Natl. Cancer Inst. (1980) [Pubmed]
  13. Reconstitution of lipid vesicles associated with HVJ (Sendai virus) sikes. Purification and some properties of vesicles containing nontoxic fragment A of diphtheria toxin. Uchida, T., Kim, J., Yamaizumi, M., Miyake, Y., Okada, Y. J. Cell Biol. (1979) [Pubmed]
  14. The paramyxovirus, Sendai virus, V protein encodes a luxury function required for viral pathogenesis. Kato, A., Kiyotani, K., Sakai, Y., Yoshida, T., Nagai, Y. EMBO J. (1997) [Pubmed]
  15. Structural and functional analysis of interferon regulatory factor 3: localization of the transactivation and autoinhibitory domains. Lin, R., Mamane, Y., Hiscott, J. Mol. Cell. Biol. (1999) [Pubmed]
  16. Phosphoprotein of the rinderpest virus forms a tetramer through a coiled coil region important for biological function. A structural insight. Rahaman, A., Srinivasan, N., Shamala, N., Shaila, M.S. J. Biol. Chem. (2004) [Pubmed]
  17. A peptide derived from a conserved domain of Sendai virus fusion protein inhibits virus-cell fusion. A plausible mode of action. Ghosh, J.K., Shai, Y. J. Biol. Chem. (1998) [Pubmed]
  18. Ir gene control of the cytotoxic T lymphocyte response to Sendai virus: H-2k mice are low responders to Sendai. Shapiro, M.E., Burakoff, S.J., Benacerraf, B., Finberg, R.W. J. Immunol. (1981) [Pubmed]
  19. Phosphorylation of Sendai virus phosphoprotein by cellular protein kinase C zeta. Huntley, C.C., De, B.P., Banerjee, A.K. J. Biol. Chem. (1997) [Pubmed]
  20. V irus and lectin agglutination of erythrocytes: spin label study of membrane lipid-protein interactions. Lyles, D.S., Landsberger, F.R. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  21. Purification of the fusion protein of Sendai virus: analysis of the NH2-terminal sequence generated during precursor activation. Gething, M.J., White, J.M., Waterfield, M.D. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  22. Somatic hybrid of thymus leukemia (. Liang, W., Cohen, E.P. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  23. Priming affects the activity of a specific region of the promoter of the human beta interferon gene. Dron, M., Lacasa, M., Tovey, M.G. Mol. Cell. Biol. (1990) [Pubmed]
  24. The mannose receptor mediates induction of IFN-alpha in peripheral blood dendritic cells by enveloped RNA and DNA viruses. Milone, M.C., Fitzgerald-Bocarsly, P. J. Immunol. (1998) [Pubmed]
  25. Stimulation of interferon and cytokine gene expression by imiquimod and stimulation by Sendai virus utilize similar signal transduction pathways. Megyeri, K., Au, W.C., Rosztoczy, I., Raj, N.B., Miller, R.L., Tomai, M.A., Pitha, P.M. Mol. Cell. Biol. (1995) [Pubmed]
  26. Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA. Servant, M.J., Grandvaux, N., tenOever, B.R., Duguay, D., Lin, R., Hiscott, J. J. Biol. Chem. (2003) [Pubmed]
  27. Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes. Li, K., Chen, Z., Kato, N., Gale, M., Lemon, S.M. J. Biol. Chem. (2005) [Pubmed]
  28. Regulation of the transcriptional activity of the IRF7 promoter by a pathway independent of interferon signaling. Ning, S., Huye, L.E., Pagano, J.S. J. Biol. Chem. (2005) [Pubmed]
  29. A CCR2-V64I polymorphism affects stability of CCR2A isoform. Nakayama, E.E., Tanaka, Y., Nagai, Y., Iwamoto, A., Shioda, T. AIDS (2004) [Pubmed]
  30. Fusion-mediated microinjection of lysozyme into HepG2 cells through hemagglutinin neuraminidase-depleted Sendai virus envelopes. Bagai, S., Sarkar, D.P. J. Biol. Chem. (1994) [Pubmed]
  31. Induction of CD8+ T cell responses to dominant and subdominant epitopes and protective immunity to Sendai virus infection by DNA vaccination. Chen, Y., Webster, R.G., Woodland, D.L. J. Immunol. (1998) [Pubmed]
  32. Airway-directed gene transfer of interleukin-10 using recombinant Sendai virus effectively prevents post-transplant fibrous airway obliteration in mice. Shoji, F., Yonemitsu, Y., Okano, S., Yoshino, I., Nakagawa, K., Nakashima, Y., Hasegawa, M., Sugimachi, K., Sueishi, K. Gene Ther. (2003) [Pubmed]
  33. Ficoll and dextran enhance adhesion of Sendai virus to liposomes containing receptor (ganglioside GD1a). Haywood, A.M., Boyer, B.P. Biochemistry (1986) [Pubmed]
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