Your search matched a total of 41 documents. Results 1 - 10.
Homo sapiens
Gene: ... Disease relevance of KEAP1 Sequencing of KEAP1 in 12 cell lines and 54 non- small- cell lung cancer( NSCLC) samples revealed somatic mutations in KEAP1 in a total of six cell lines and ten tumors... protein, Keap1, might be an important mechanism for the increased nuclear translocation and activation...
Rattus norvegicus
Gene: ... High impact information on Keap1 However, it partially impaired Nrf2 activation of ARE- driven transcription in a reporter gene assay when Keap1 was overexpressed. Phosphorylation of wild- type Nrf2 by PKC promoted its dissociation from Keap1, whereas the Nrf2- S40A mutant remained associated. Keap1 is a newly...
Mus musculus
Gene: ... Disease relevance of Keap1 A recombinant protein containing both the Kelch/ DGR domain and the C- terminal region of mouse Keap1 was expressed in Escherichia coli, purified to near- homogeneity... that the Nrf2- Keap1 system contributes to protection against various pathologies, including carcinogenesis...
Drosophila melanogaster
Gene: Synonyms: KEAP1; dKEAP1; dKeap1
MeSH term: ... a significant difference in apnea. High impact information on Esophagus When we ablated Keap1, Keap1- deficient... occurred in all 15 rats, squamous papillomas o- the esophagus in 1, squamous papillomas of the nonglandular... riboprobes and/ or synthetic oligonucleotides shows the presence of cytokeratin 15 mRNA in all layers...
Homo sapiens
Gene: ... with lung cancer, enabling the transcription factor to evade KEAP1- mediated repression. In univariate... of chemical signals imparted by oxidative and electrophilic molecules, Nrf2 is released from Keap1, escapes...) is regulated. Keap1 is a BTB- Kelch substrate adaptor protein that regulates steady- state levels of Nrf2, a b...
Mus musculus
Gene: ... recognition of chemical signals imparted by oxidative and electrophilic molecules, Nrf2 is released from Keap1... dozen cytoprotective genes that enhance cell survival. We postulate that Keap1 and Nrf2 constitute... protein, which we named Keap1, that suppresses Nrf2 transcriptional activity by specific binding to its...
Chemical compound: ... inducers such as sulforaphane are known to react with Keap1 cysteine residues, thereby promoting Nrf2...- hydroxybenzylideneacetone Michael reaction acceptor. We cloned, overexpressed, and purified murine Keap1 and demonstrated on native gels the formation of complexes of Keap1 with the Neh2 domain of Nrf2 and their concentration...
Chemical compound: ... , which encodes the quinone- metabolizing enzyme DT- diaphorase. Keap1- dependent ubiquitination of Nrf2... insight that all bioenergetic membranes run on the conversion of redox energy into transmembrane...
Links to contributing authors:
Steven Johnsen and Donald R. Forsdyke and Kehinde Ross and Andrew Perry and Jonathan Eisen and A. Shimabukuro-Vornhagen and Giuseppe Rotondo and Gordon Laurie and Berkley Lynch and Kung-Hao Liang and Matthias Gstaiger and Thomas Pfeiffer and Marta Ramirez and Grant MacGregor and Jingyu Li and Fedik Rahimov and M El Gizouli and Marta Ramirez Gaite and Oswaldo Ribeiro-filho and Ralf Weigel and Bjoern Hamberger and Alexander Kanitz and Andreas Zankl and Chunming Ding and Maruf Yunus and Jonathan S. Berg and Michael Cariaso and Zakir Thomas and Monique Timberlake-Brady and LC Dore and Nan Shen and R. Eric Collins and Kuang-Mao Chiang and Brendan McMahon and John Chew and Wen-Ming Yang and Robert Hoffmann and J.B. Stewart and Manuela Cucerea and Ignacio García and William James and Thomas Kelder and Gregory Melahn and YINGDE ZHU and Andres Muro and Gabriel Santpere and Jeff Freilich and Junbin Qian and Steffen Poulsen and Eric Villard and Rafael Sidi and Grant Cramer and Chris Sander and Alexandre Chigaev and Florian Uhle and Carl Fulp and Andrew Brown and Xiaozhu Zhou and Corina Dutu and Hilary Spencer and david germano and Abbas Dehghan and Eung-ju PARK and Chris Sander and Albert Vilella and Miao Tian and Anjali Bheda and Michael Nevels and Jun Liu and D Delano and Chitose Taya and Soomi Cheong and David Kavanagh and Maha Karnoub and Hilmar Lapp and Christian Pallasch and Daniel Mietchen and Biju Balakrishnan and Keith Ashman and Juan Carlos Sobrino and Anshu Bhardwaj and Grzegorz Wickiel and Matthew Day and Anthony Sebastian and Vedran Katavic and Liang Long and Barry Wanner and Sarah Snelling and Fernando Montanes and Omobosede Fashedemi and Gustavo Cervantes and Manoj Kumar and Edward D Great and Paul Paukstelis and Roy Soetikno and Ana I Caño-Delgado and Minsoo Choi and Lei Wang and Brenda Riley and A Michelle Moon and Jon Moulton and Mahmoud Elshahawy and Meagan Gillespie and Banundari Rachmawati and Qian Han and Eric Danner and Xavier Fouillet and Madhusudhan Acharya and Brian Young and Chandra Sekhar Mukhopadhyay and shrawan bhattacharjee and Marieke van der Linden and cj hoban and Sandi Pniauskas and jackie gao and Metin Bilgin and Gillian L. Dalgliesh and Karl Wotton and Iveta Herichova and Yuji Morita and Marta Hernandez and Gregor Krings and Marco Briones and Tim D. Smith and Yiumo Michael Chan and Zhenyu Guo and Barry Barclay and Hong Wang and tarali chowdhury and Tilman Brummer and Nuno Faria and Tamir Ben David and Myles Axton and Yannick Fonseca and Francis Castets and Modesto Redrejo-Rodríguez and Bruce Herron and Toshio Fujita and Elena Puccetti and Zhang Zhang and John Osborne and Illes J Farkas and Fernando Andres and Phyllis Pugh and Jonathan Court and Tim Vickers and Nir Friedman and Holger Dick and Ya-Chen Liang and Jonathan Froehlich and Haitham Sobhy and David Abraham and Stephane Krief and Yaroslav Nikolaev and Qiping Feng and d gupta and R Thapar and Susan Wee and Michael Rehman and SOUMITRA GHOSH and Mohamed Eweida and Cedric Uytingco and Nie hongchuan and David Steenblock and Mark A. Kukucka and Zoli Fekete and Sergei Kozlov and Javier Jara and Osama Naguib and Felix Benninger and jean-marc lo-guidice and VASUDEVA BHAT and Anne O. Summers and Bjoern Titz and Anna Levine and Klas Udekwu and Robert Hoffmann







