The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Esophagus


Psychiatry related information on Esophagus


High impact information on Esophagus

  • When we ablated Keap1, Keap1-deficient mice died postnatally, probably from malnutrition resulting from hyperkeratosis in the esophagus and forestomach [11].
  • Concomitant with the expression of LMP in this tissue (and in the esophagus) is an induction of the expression of a hyperproliferative keratin, K6, at aberrant locations within the epidermis [12].
  • A 15-ml bolus of 0.1 N hydrochloric acid (pH 1.2) radiolabeled with [99mTc]sulfur colloid was injected into the esophagus, and the subject swallowed every 30 seconds [13].
  • The p53 mutational spectrum differs among cancers of the colon, lung, esophagus, breast, liver, brain, reticuloendothelial tissues, and hemopoietic tissues [14].
  • We report here that ethanol activates primary sensory neurons, resulting in neuropeptide release or plasma extravasation in the esophagus, spinal cord or skin [15].

Chemical compound and disease context of Esophagus


Biological context of Esophagus


Anatomical context of Esophagus


Associations of Esophagus with chemical compounds


Gene context of Esophagus


Analytical, diagnostic and therapeutic context of Esophagus


  1. Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus. Herskovic, A., Martz, K., al-Sarraf, M., Leichman, L., Brindle, J., Vaitkevicius, V., Cooper, J., Byhardt, R., Davis, L., Emami, B. N. Engl. J. Med. (1992) [Pubmed]
  2. The relation of gastroesophageal reflux disease and its treatment to adenocarcinomas of the esophagus and gastric cardia. Chow, W.H., Finkle, W.D., McLaughlin, J.K., Frankl, H., Ziel, H.K., Fraumeni, J.F. JAMA (1995) [Pubmed]
  3. Biologic properties of three newly established human esophageal carcinoma cell lines. Hu, C.P., Hsieh, H.G., Chien, K.Y., Wang, P.Y., Wang, C.I., Chen, C.Y., Lo, S.J., Wuu, K.D., Chang, C.M. J. Natl. Cancer Inst. (1984) [Pubmed]
  4. Carcinogenicity of N'-nitrosonornicotine in Sprague-Dawley rats. Singer, G.M., Taylor, H.W. J. Natl. Cancer Inst. (1976) [Pubmed]
  5. Anti-p53 antibodies in sera of workers occupationally exposed to vinyl chloride. Trivers, G.E., Cawley, H.L., DeBenedetti, V.M., Hollstein, M., Marion, M.J., Bennett, W.P., Hoover, M.L., Prives, C.C., Tamburro, C.C., Harris, C.C. J. Natl. Cancer Inst. (1995) [Pubmed]
  6. The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl-D-aspartate receptor. Willert, R.P., Woolf, C.J., Hobson, A.R., Delaney, C., Thompson, D.G., Aziz, Q. Gastroenterology (2004) [Pubmed]
  7. Tobacco, alcohol, diet, occupation, and carcinoma of the esophagus. Yu, M.C., Garabrant, D.H., Peters, J.M., Mack, T.M. Cancer Res. (1988) [Pubmed]
  8. Neuronal substance P in the esophagus. Distribution and effects on motor activity. Leander, S., Brodin, E., Håkanson, R., Sundler, F., Uddman, R. Acta Physiol. Scand. (1982) [Pubmed]
  9. Effect of severe gastroesophageal reflux on sleep stage in patients with aperistaltic esophagus. Shoenut, J.P., Yamashiro, Y., Orr, W.C., Kerr, P., Micflikier, A.B., Kryger, M.H. Dig. Dis. Sci. (1996) [Pubmed]
  10. The relationship between extraesophageal reflux (EER) and obstructive sleep apnea (OSA). Zanation, A.M., Senior, B.A. Sleep medicine reviews. (2005) [Pubmed]
  11. Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Wakabayashi, N., Itoh, K., Wakabayashi, J., Motohashi, H., Noda, S., Takahashi, S., Imakado, S., Kotsuji, T., Otsuka, F., Roop, D.R., Harada, T., Engel, J.D., Yamamoto, M. Nat. Genet. (2003) [Pubmed]
  12. Expression of the BNLF-1 oncogene of Epstein-Barr virus in the skin of transgenic mice induces hyperplasia and aberrant expression of keratin 6. Wilson, J.B., Weinberg, W., Johnson, R., Yuspa, S., Levine, A.J. Cell (1990) [Pubmed]
  13. Effect of esophageal emptying and saliva on clearance of acid from the esophagus. Helm, J.F., Dodds, W.J., Pelc, L.R., Palmer, D.W., Hogan, W.J., Teeter, B.C. N. Engl. J. Med. (1984) [Pubmed]
  14. p53 mutations in human cancers. Hollstein, M., Sidransky, D., Vogelstein, B., Harris, C.C. Science (1991) [Pubmed]
  15. Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1. Trevisani, M., Smart, D., Gunthorpe, M.J., Tognetto, M., Barbieri, M., Campi, B., Amadesi, S., Gray, J., Jerman, J.C., Brough, S.J., Owen, D., Smith, G.D., Randall, A.D., Harrison, S., Bianchi, A., Davis, J.B., Geppetti, P. Nat. Neurosci. (2002) [Pubmed]
  16. An etiological role for aeroallergens and eosinophils in experimental esophagitis. Mishra, A., Hogan, S.P., Brandt, E.B., Rothenberg, M.E. J. Clin. Invest. (2001) [Pubmed]
  17. Expression of substance P/neurokinin A-encoding preprotachykinin messenger ribonucleic acids in the rat enteric nervous system. Sternini, C., Anderson, K., Frantz, G., Krause, J.E., Brecha, N. Gastroenterology (1989) [Pubmed]
  18. Rofecoxib inhibits cyclooxygenase 2 expression and activity and reduces cell proliferation in Barrett's esophagus. Kaur, B.S., Khamnehei, N., Iravani, M., Namburu, S.S., Lin, O., Triadafilopoulos, G. Gastroenterology (2002) [Pubmed]
  19. Leukotriene D4-induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle. Kim, N., Cao, W., Song, I.S., Kim, C.Y., Sohn, U.D., Harnett, K.M., Biancani, P. Gastroenterology (1998) [Pubmed]
  20. Nifedipine: a potent inhibitor of contractions in the body of the human esophagus. Studies in healthy volunteers and patients with the nutcracker esophagus. Richter, J.E., Dalton, C.B., Buice, R.G., Castell, D.O. Gastroenterology (1985) [Pubmed]
  21. Effect of ethanol and vitamin A deficiency on epithelial cell proliferation and structure in the rat esophagus. Mak, K.M., Leo, M.A., Lieber, C.S. Gastroenterology (1987) [Pubmed]
  22. The ontogeny and distribution of neuropeptides in the human fetal and infant esophagus. Hitchcock, R.J., Pemble, M.J., Bishop, A.E., Spitz, L., Polak, J.M. Gastroenterology (1992) [Pubmed]
  23. Relation between volume swallowed and velocity of the bolus ejected from the pharynx into the esophagus. Fisher, M.A., Hendrix, T.R., Hunt, J.N., Murrills, A.J. Gastroenterology (1978) [Pubmed]
  24. The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. Vasioukhin, V., Degenstein, L., Wise, B., Fuchs, E. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  25. Mechanism of esophageal tumor induction in rats by N-nitrosomethylbenzylamine and its ring-methylated analog N-nitrosomethyl(4-methylbenzyl)amine. Hodgson, R.M., Schweinsberg, F., Wiessler, M., Kleihues, P. Cancer Res. (1982) [Pubmed]
  26. Suppression of dibutylnitrosamine-induced bladder carcinomas in hamsters by dietary indole. Matsumoto, M., Oyasu, R., Hopp, M.L., Kitajima, T. J. Natl. Cancer Inst. (1977) [Pubmed]
  27. Effect of riboflavin, retinol, and zinc on micronuclei of buccal mucosa and of esophagus: a randomized double-blind intervention study in China. Muñoz, N., Hayashi, M., Bang, L.J., Wahrendorf, J., Crespi, M., Bosch, F.X. J. Natl. Cancer Inst. (1987) [Pubmed]
  28. Identification, isolation, and partial characterization of a fatty acid binding protein from rat jejunal microvillous membranes. Stremmel, W., Lotz, G., Strohmeyer, G., Berk, P.D. J. Clin. Invest. (1985) [Pubmed]
  29. Induction and suppression of N-nitrosomethylbenzylamine activation by microsomes from rat liver and esophagus. Mehta, R., Labuc, G.E., Archer, M.C. J. Natl. Cancer Inst. (1984) [Pubmed]
  30. Induction of cytochrome P450IA genes (CYP1A) by omeprazole in the human alimentary tract. McDonnell, W.M., Scheiman, J.M., Traber, P.G. Gastroenterology (1992) [Pubmed]
  31. Effects of dietary N-(4-hydroxyphenyl)retinamide on N-nitrosomethylbenzylamine metabolism and esophageal tumorigenesis in the Fischer 344 rat. Gupta, A., Nines, R., Rodrigo, K.A., Aziz, R.A., Carlton, P.S., Gray, D.L., Steele, V.E., Morse, M.A., Stoner, G.D. J. Natl. Cancer Inst. (2001) [Pubmed]
  32. Effect of vitamin A nutriture on experimental esophageal carcinogenesis. Nauss, K.M., Bueche, D., Newberne, P.M. J. Natl. Cancer Inst. (1987) [Pubmed]
  33. Histopathology of preneoplastic and neoplastic lesions of the esophagus in BUF rats ingesting diethylnitrosamine. Reuber, M.D. J. Natl. Cancer Inst. (1977) [Pubmed]
  34. Distribution and density of substance P receptors in the feline gastrointestinal tract using autoradiography. Rothstein, R.D., Johnson, E., Ouyang, A. Gastroenterology (1991) [Pubmed]
  35. Tobacco carcinogen-detoxifying enzyme UGT1A7 and its association with orolaryngeal cancer risk. Zheng, Z., Park, J.Y., Guillemette, C., Schantz, S.P., Lazarus, P. J. Natl. Cancer Inst. (2001) [Pubmed]
  36. Prognostic significance of elevated cyclooxygenase 2 expression in patients with adenocarcinoma of the esophagus. Buskens, C.J., Van Rees, B.P., Sivula, A., Reitsma, J.B., Haglund, C., Bosma, P.J., Offerhaus, G.J., Van Lanschot, J.J., Ristimäki, A. Gastroenterology (2002) [Pubmed]
  37. Distributions of neuropeptides in the human esophagus. Wattchow, D.A., Furness, J.B., Costa, M., O'Brien, P.E., Peacock, M. Gastroenterology (1987) [Pubmed]
  38. Mutations and altered expression of p16INK4 in human cancer. Okamoto, A., Demetrick, D.J., Spillare, E.A., Hagiwara, K., Hussain, S.P., Bennett, W.P., Forrester, K., Gerwin, B., Serrano, M., Beach, D.H. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  39. Sequence and expression of the murine Hoxd-3 homeobox gene. Tan, D.P., Shao, X., Pu, L., Guo, V., Nirenberg, M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  40. Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. Kuhn, K.A., Kulik, L., Tomooka, B., Braschler, K.J., Arend, W.P., Robinson, W.H., Holers, V.M. J. Clin. Invest. (2006) [Pubmed]
  41. Acute experimental esophagitis impairs signal transduction in cat lower esophageal sphincter circular muscle. Biancani, P., Billett, G., Hillemeier, C., Nissensohn, M., Rhim, B.Y., Szewczak, S., Behar, J. Gastroenterology (1992) [Pubmed]
  42. Molecular characterization and expression of the stratification-related cytokeratins 4 and 15. Leube, R.E., Bader, B.L., Bosch, F.X., Zimbelmann, R., Achtstaetter, T., Franke, W.W. J. Cell Biol. (1988) [Pubmed]
  43. Cisplatin, vinblastine, and mitoguazone chemotherapy for epidermoid and adenocarcinoma of the esophagus. Forastiere, A.A., Gennis, M., Orringer, M.B., Agha, F.P. J. Clin. Oncol. (1987) [Pubmed]
  44. Influence of esophagojejunostomy on the induction of adenocarcinoma of the distal esophagus in Sprague-Dawley rats by subcutaneous injection of 2,6-dimethylnitrosomorpholine. Pera, M., Cardesa, A., Bombi, J.A., Ernst, H., Pera, C., Mohr, U. Cancer Res. (1989) [Pubmed]
WikiGenes - Universities