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Gene Review:

Keap1 - Kelch-like ECH-associated protein 1

Rattus norvegicus

Synonyms: Cytosolic inhibitor of Nrf2, INrf2, Inrf2

Velichkova, M. et al., Huang, H.C. et al.

Velichkova, Hasson,

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High impact information on Keap1

However, it partially impaired Nrf2 activation of ARE-driven transcription in a reporter gene assay when Keap1 was overexpressed [1].
Phosphorylation of wild-type Nrf2 by PKC promoted its dissociation from Keap1, whereas the Nrf2-S40A mutant remained associated [1].
Keap1 is a newly identified component of cell adhesion complexes [2].
Keap1 is present in focal adhesion (FA)-like assemblies in kidney proximal tubule cells where it colocates with actin [2].
In liver, Keap1 is found in the adherens junctions (AJ) and at the base of the bile canaliculi [2].

Other interactions of Keap1

Within the peripheral FA, Keap1 was present in distinct foci along the length of the FA and these foci were different from vinculin, talin, paxillin, and phospho-tyrosine rich regions of the FA [2].

References

Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription. Huang, H.C., Nguyen, T., Pickett, C.B. J. Biol. Chem. (2002) [Pubmed]
Keap1 in adhesion complexes. Velichkova, M., Hasson, T. Cell Motil. Cytoskeleton (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP003645	Anopheles gambiae str. PEST
KEAP1	Bos taurus
KEAP1	Canis lupus familiaris
keap1b	Danio rerio
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KEAP1	Homo sapiens
Keap1	Mus musculus
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keap1	Xenopus (Silurana) tropicalis

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