Your search matched a total of 48 documents. Results 1 - 10.
Caenorhabditis elegans
Gene: ... High impact information on lig- 4 C. elegans strains harboring mutations in the cku- 70, cku- 80, or lig- 4 NHEJ genes displayed multiple developmental abnormalities in response to radiation- induced DNA damage in noncycling somatic cells....
Homo sapiens
Gene: ... Disease relevance of LIG4 A new type of radiosensitive T- B- NK+ severe combined immunodeficiency caused by a LIG4 mutation. To date, LIG4 mutations have only been described in a radiosensitive leukemia patient and in 4 patients with a designated LIG4 syndrome, which is associated with chromosomal...
Drosophila melanogaster
Gene: ... High impact information on Lig4 The disorganized nucleolus phenotype depends on the presence... the evolutionarily conserved Ku80 and ligase IV factors. Lig4 and rad54 are required for repair of DNA double- strand breaks induced by P- element excision in Drosophila. Survival of lig4- deficient females was not affected... / Synonyms: lig4
Mus musculus
Gene: ... Disease relevance of Lig4 Young Lig4/ p53 double null mice routinely died from pro- B lymphomas... impact information on Lig4 Ligase IV- deficient embryonic fibroblasts also show marked sensitivity to ionizing radiation, growth defects and premature senescence. We show that Lig4 and Rad54 cooperate...
Gallus gallus
Gene: ... High impact information on RCJMB04_ 10b2 The LIG4 (-/-) cells showed a marked sensitivity to X..., suggesting a critical role of Lig4 in DSB repair by NHEJ. Our data may explain the observed severe phenotype of Lig4- deficient mice as compared with Ku- deficient mice....
Arabidopsis thaliana
Gene: ... Disease relevance of ATLIG4 Recently, we showed that a yeast lig4 mutant is deficient... agents methyl methanesulfonate and X- rays, demonstrating that AtLIG4 is required for the repair of DNA damage. Biological context of ATLIG4 The Arabidopsis AtLIG4 gene is required for the repair of DNA damage... / Synonyms: LIG4
Saccharomyces cerevisiae S288c
Gene: ... in the absence of RAD50, YKU70, and LIG4, indicating that palindrome formation defines a new class... sequence homology with human DNA ligase IV; accordingly, we designate the yeast gene LIG4. These telomere... for nonhomologous end joining( NHEJ ), including Lig4( ligase IV ), KU and the Mre11 complex. Biological context... / Synonyms: LIG4
Links to contributing authors:
Steven Johnsen and Donald R. Forsdyke and Kehinde Ross and Andrew Perry and Jonathan Eisen and A. Shimabukuro-Vornhagen and Giuseppe Rotondo and Gordon Laurie and Berkley Lynch and Kung-Hao Liang and Matthias Gstaiger and Thomas Pfeiffer and Marta Ramirez and Grant MacGregor and Jingyu Li and Fedik Rahimov and M El Gizouli and Marta Ramirez Gaite and Oswaldo Ribeiro-filho and Ralf Weigel and Bjoern Hamberger and Alexander Kanitz and Andreas Zankl and Chunming Ding and Maruf Yunus and Jonathan S. Berg and Michael Cariaso and Zakir Thomas and Monique Timberlake-Brady and LC Dore and Nan Shen and R. Eric Collins and Kuang-Mao Chiang and Brendan McMahon and John Chew and Wen-Ming Yang and Robert Hoffmann and J.B. Stewart and Manuela Cucerea and Ignacio García and William James and Thomas Kelder and Gregory Melahn and YINGDE ZHU and Andres Muro and Gabriel Santpere and Jeff Freilich and Junbin Qian and Steffen Poulsen and Eric Villard and Rafael Sidi and Grant Cramer and Chris Sander and Alexandre Chigaev and Florian Uhle and Carl Fulp and Andrew Brown and Xiaozhu Zhou and Corina Dutu and Hilary Spencer and david germano and Abbas Dehghan and Eung-ju PARK and Chris Sander and Albert Vilella and Miao Tian and Anjali Bheda and Michael Nevels and Jun Liu and D Delano and Chitose Taya and Soomi Cheong and David Kavanagh and Maha Karnoub and Hilmar Lapp and Christian Pallasch and Daniel Mietchen and Biju Balakrishnan and Keith Ashman and Juan Carlos Sobrino and Anshu Bhardwaj and Grzegorz Wickiel and Matthew Day and Anthony Sebastian and Vedran Katavic and Liang Long and Barry Wanner and Sarah Snelling and Fernando Montanes and Omobosede Fashedemi and Gustavo Cervantes and Manoj Kumar and Edward D Great and Paul Paukstelis and Roy Soetikno and Ana I Caño-Delgado and Minsoo Choi and Lei Wang and Brenda Riley and A Michelle Moon and Jon Moulton and Mahmoud Elshahawy and Meagan Gillespie and Banundari Rachmawati and Qian Han and Eric Danner and Xavier Fouillet and Madhusudhan Acharya and Brian Young and Chandra Sekhar Mukhopadhyay and shrawan bhattacharjee and Marieke van der Linden and cj hoban and Sandi Pniauskas and jackie gao and Metin Bilgin and Gillian L. Dalgliesh and Karl Wotton and Iveta Herichova and Yuji Morita and Marta Hernandez and Gregor Krings and Marco Briones and Tim D. Smith and Yiumo Michael Chan and Zhenyu Guo and Barry Barclay and Hong Wang and tarali chowdhury and Tilman Brummer and Nuno Faria and Tamir Ben David and Myles Axton and Yannick Fonseca and Francis Castets and Modesto Redrejo-Rodríguez and Bruce Herron and Toshio Fujita and Elena Puccetti and Zhang Zhang and John Osborne and Illes J Farkas and Fernando Andres and Phyllis Pugh and Jonathan Court and Tim Vickers and Nir Friedman and Holger Dick and Ya-Chen Liang and Jonathan Froehlich and Haitham Sobhy and David Abraham and Stephane Krief and Yaroslav Nikolaev and Qiping Feng and d gupta and R Thapar and Susan Wee and Michael Rehman and SOUMITRA GHOSH and Mohamed Eweida and Cedric Uytingco and Nie hongchuan and David Steenblock and Mark A. Kukucka and Zoli Fekete and Sergei Kozlov and Javier Jara and Osama Naguib and Felix Benninger and jean-marc lo-guidice and VASUDEVA BHAT and Anne O. Summers and Bjoern Titz and Anna Levine and Klas Udekwu and Robert Hoffmann
