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Gene Review

Lig4  -  Ligase4

Drosophila melanogaster

Synonyms: CG12176, Dmel\CG12176, RE37186, lig4, ligIV, ...
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High impact information on Lig4

  • The disorganized nucleolus phenotype depends on the presence of Ligase 4 and ecc DNA formation is not induced by removal of cohesin [1].
  • Analysis of DSB repair during MosTIC experiments demonstrated that DSBs could also be sealed by end-joining in the germ line, independently from the evolutionarily conserved Ku80 and ligase IV factors [2].
  • Lig4 and rad54 are required for repair of DNA double-strand breaks induced by P-element excision in Drosophila [3].
  • Survival of lig4-deficient females was not affected at all, implying that HR using the homologous chromosome as a template can partially compensate for the impaired NHEJ pathway [3].
  • To elucidate the role of DNA Ligase IV (Lig4) in DSB repair in a multicellular lower eukaryote, we generated viable Lig4-deficient Drosophila strains by P-element-mediated mutagenesis [4].

Regulatory relationships of Lig4


Other interactions of Lig4

  • To determine the relative contribution of NHEJ and homologous recombination (HR) in Drosophila, Lig4; Rad54 double-mutant flies were generated [4].


  1. H3K9 methylation and RNA interference regulate nucleolar organization and repeated DNA stability. Peng, J.C., Karpen, G.H. Nat. Cell Biol. (2007) [Pubmed]
  2. Targeted engineering of the Caenorhabditis elegans genome following Mos1-triggered chromosomal breaks. Robert, V., Bessereau, J.L. EMBO J. (2007) [Pubmed]
  3. Lig4 and rad54 are required for repair of DNA double-strand breaks induced by P-element excision in Drosophila. Romeijn, R.J., Gorski, M.M., van Schie, M.A., Noordermeer, J.N., Mullenders, L.H., Ferro, W., Pastink, A. Genetics (2005) [Pubmed]
  4. The Drosophila melanogaster DNA Ligase IV gene plays a crucial role in the repair of radiation-induced DNA double-strand breaks and acts synergistically with Rad54. Gorski, M.M., Eeken, J.C., de Jong, A.W., Klink, I., Loos, M., Romeijn, R.J., van Veen, B.L., Mullenders, L.H., Ferro, W., Pastink, A. Genetics (2003) [Pubmed]
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