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Gene Review

LIG4  -  ligase IV, DNA, ATP-dependent

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  • The LIG4(-/-) cells showed a marked sensitivity to X-rays, bleomycin, and VP-16 and were more x-ray-sensitive in G(1) than late S or G(2)/M, suggesting a critical role of Lig4 in DSB repair by NHEJ [1].
  • Our data may explain the observed severe phenotype of Lig4-deficient mice as compared with Ku-deficient mice [1].


  1. DNA ligase IV-deficient cells are more resistant to ionizing radiation in the absence of Ku70: Implications for DNA double-strand break repair. Adachi, N., Ishino, T., Ishii, Y., Takeda, S., Koyama, H. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
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