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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Your search matched a total of 148 documents. Results 1 - 10.

Mus musculus
Gene: ... disorders: albinism, piebaldism, and vitiligo, all of which throw light on normal pigment cell function...Disease relevance of Mitf This linkage helps explain the vital roles of both Mitf and Bcl2... in Mitf or Tfe3 null mice, the combined loss of the two genes results in severe osteopetrosis...
Homo sapiens
Gene: ... Disease relevance of MITF Clinically, primary human melanoma expression microarrays revealed tight nearest neighbor linkage for MITF and BCL2. MITF mutations occur in patients with Waardenburg syndrome... loss in WS2 are likely to be the results of an anomaly of melanocyte differentiation caused by MITF...
Drosophila melanogaster
Gene: ... High impact information on Mitf In vitro, transcriptional regulation by Drosophila Mitf, like its... the structure of the Mitf gene in Drosophila and demonstrate expression during embryonic development and in the eye- antennal imaginal disc. The MITF protein is a member of the MYC family of basic helix- loop... / Synonyms: MITF; dMitf
Gallus gallus
Gene: ... Disease relevance of MITF Mitf overexpression caused hyperpigmentation in cultured rPECs and suppressed the changes in gene expression induced by bFGF. High impact information on MITF Replacement... of the RPE- marker Mitf. These findings showed that downregulation of Mitf expression is essential...
Canis lupus familiaris
Gene: Synonyms: MITF-H; MITF-M
Xenopus (Silurana) tropicalis
Gene: Synonyms: MITF-A
MeSH term: ... expression microarrays revealed tight nearest neighbor linkage for MITF and BCL2. This linkage helps explain the vital roles of both Mitf and Bcl2 in the melanocyte lineage and the well- known treatment resistance... melanoma. A preliminary report. BCL2' s regulation by Mitf was verified in melanocytes and melanoma cells...
Mus musculus
Gene: ... the reduction in goblet- cell number, the total amount of ITF was increased in the mITF/ DT- A transgenic mice...) and acetic acid, to assess the susceptibility of mITF/ DT- A transgenic mice to colonic injury. To assess... promoter; other cell lineages were unaffected. Chemical compound and disease context of Tff3 The mITF... / Synonyms: mITF
Mus musculus
Gene: ... inhibited by Id, a HLH protein, and this inhibition was reversed by the addition of excess E12 or MITF- 2A.... This inhibitory activity required the N- terminal 83 amino acids since MITF- 2A showed no inhibitory activity, and a mutant MITF- 2B with deletion of the N- terminal 83 amino acids failed to inhibit MyoD- mediated... / Synonyms: MITF-2; MITF-2A; MITF-2B
MeSH term: ... and is 55% identical to a human EST of unknown function isolated from melanocytes and melanoma cells. MITF... on Melanocytes To identify Mitf- dependent Kit transcriptional targets in primary melanocytes, microarray studies were undertaken. Kit/ SCF signaling and Mitf- dependent transcription are both essential for melanocyte...


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