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Gene Review

Tff3  -  trefoil factor 3, intestinal

Mus musculus

Synonyms: ITF, Intestinal trefoil factor, Itf, Trefoil factor 3, mITF
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Disease relevance of Tff3

  • Mice lacking ITF had impaired mucosal healing and died from extensive colitis after oral administration of dextran sulfate sodium, an agent that causes mild epithelial injury in wild-type mice [1].
  • CONCLUSIONS: These studies suggest that intestinal trefoil factor is involved in protection against and recovery from intestinal mucositis induced by radiation and chemotherapy [2].
  • Mice given a complex inoculum of B. fragilis, enterococcus, and another anaerobe develop abscesses even after receiving column-purified ITF [3].
  • ITF may function as an inhibitory factor for the growth of colonic neoplasm [4].
  • To analyze the role of ITF in colon carcinomas, overexpression of the ITF gene in colon carcinoma cells was used [4].

High impact information on Tff3


Chemical compound and disease context of Tff3


Biological context of Tff3


Anatomical context of Tff3


Associations of Tff3 with chemical compounds

  • An ITF-expressing colonic (HT-ITF1) cell line was resistant to apoptosis induced by serum starvation and ceramide [13].
  • The intraduodenal absorption of a new low-molecular-weight heparin (LMWH) diamine salt (ITF 1331) was compared with the parent compound ITF 1060 and with sodium LMWH, in anaesthetized rabbits [14].
  • Data obtained with these new compounds showed that ITF 1697 has antianaphylactic activity, while ITF 2018 is endowed, mainly, with antiinflammatory activity [15].
  • Two new chemical entities were studied according to this protocol: ITF 1697, a chemically stabilized C-reactive protein-derived tetrapeptide, and ITF 2018, a leflunomide analogue [15].
  • Gene activation by EE was not required for inhibition of inflammatory gene expression, because both the phytoestrogen genistein and low doses of EE were effective in blocking inflammatory gene induction without inducing marker genes such as intestinal trefoil factor (ITF) or myo-inositol-1-phosphate synthase (IPS) [16].

Other interactions of Tff3


Analytical, diagnostic and therapeutic context of Tff3


  1. Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor. Mashimo, H., Wu, D.C., Podolsky, D.K., Fishman, M.C. Science (1996) [Pubmed]
  2. Chemotherapy- and radiotherapy-induced intestinal damage is regulated by intestinal trefoil factor. Beck, P.L., Wong, J.F., Li, Y., Swaminathan, S., Xavier, R.J., Devaney, K.L., Podolsky, D.K. Gastroenterology (2004) [Pubmed]
  3. A soluble suppressor T cell factor protects against experimental intraabdominal abscesses. Zaleznik, D.F., Finberg, R.W., Shapiro, M.E., Onderdonk, A.B., Kasper, D.L. J. Clin. Invest. (1985) [Pubmed]
  4. Overexpression of intestinal trefoil factor in human colon carcinoma cells reduces cellular growth in vitro and in vivo. Uchino, H., Kataoka, H., Itoh, H., Hamasuna, R., Koono, M. Gastroenterology (2000) [Pubmed]
  5. A paradoxical reduction in susceptibility to colonic injury upon targeted transgenic ablation of goblet cells. Itoh, H., Beck, P.L., Inoue, N., Xavier, R., Podolsky, D.K. J. Clin. Invest. (1999) [Pubmed]
  6. Molecular cloning of mouse intestinal trefoil factor and its expression during goblet cell changes. Tomita, M., Itoh, H., Ishikawa, N., Higa, A., Ide, H., Murakumo, Y., Maruyama, H., Koga, Y., Nawa, Y. Biochem. J. (1995) [Pubmed]
  7. Effect of non-steroidal anti-inflammatory drugs of Moloney sarcoma virus inoculated mice. Inglot, A.D., Oleszak, E. Experientia (1978) [Pubmed]
  8. Inactivation of p21WAF1/cip1 enhances intestinal tumor formation in Muc2-/- mice. Yang, W., Velcich, A., Lozonschi, I., Liang, J., Nicholas, C., Zhuang, M., Bancroft, L., Augenlicht, L.H. Am. J. Pathol. (2005) [Pubmed]
  9. The gene encoding mouse intestinal trefoil factor: structural organization, partial sequence analysis and mapping to murine chromosome 17q. Chinery, R., Poulsom, R., Cox, H.M. Gene (1996) [Pubmed]
  10. Effects of Trichinella spiralis infection on intestinal pathology in mice lacking interleukin-4 (IL-4) or intestinal trefoil factor (ITF/TFF3). Dehlawi, M.S., Mahida, Y.R., Hughes, K., Wakelin, D. Parasitol. Int. (2006) [Pubmed]
  11. Temporal expression of trefoil peptides in the TGF-alpha knockout mouse after gastric ulceration. Cook, G.A., Yeomans, N.D., Giraud, A.S. Am. J. Physiol. (1997) [Pubmed]
  12. Effect of ectopic expression of rat trefoil factor family 3 (intestinal trefoil factor) in the jejunum of transgenic mice. Marchbank, T., Cox, H.M., Goodlad, R.A., Giraud, A.S., Moss, S.F., Poulsom, R., Wright, N.A., Jankowski, J., Playford, R.J. J. Biol. Chem. (2001) [Pubmed]
  13. Intestinal trefoil factor confers colonic epithelial resistance to apoptosis. Taupin, D.R., Kinoshita, K., Podolsky, D.K. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  14. Intraduodenal absorption in the rabbit of a novel heparin salt. Andriuoli, G., Caramazza, I., Galimberti, G., Zoppetti, G., Benedini, F., Sala, A., Del Soldato, P. Haemostasis (1992) [Pubmed]
  15. Use of type I and type IV hypersensitivity responses to define the immunopharmacological profile of drugs. Di Pierro, F., d'Atri, G., Marcucci, F., Leoni, F. Journal of pharmacological and toxicological methods. (1997) [Pubmed]
  16. Reciprocal antagonism between estrogen receptor and NF-kappaB activity in vivo. Evans, M.J., Eckert, A., Lai, K., Adelman, S.J., Harnish, D.C. Circ. Res. (2001) [Pubmed]
  17. Homeostasis and function of goblet cells during rotavirus infection in mice. Boshuizen, J.A., Reimerink, J.H., Korteland-van Male, A.M., van Ham, V.J., Bouma, J., Gerwig, G.J., Koopmans, M.P., Büller, H.A., Dekker, J., Einerhand, A.W. Virology (2005) [Pubmed]
  18. Structure and expression of murine intestinal trefoil factor: high evolutionary conservation and postnatal expression. Mashimo, H., Podolsky, D.K., Fishman, M.C. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  19. Chronic nicotine administration differentially alters jejunal and colonic inflammation in interleukin-10 deficient mice. Eliakim, R., Fan, Q.X., Babyatsky, M.W. European journal of gastroenterology & hepatology. (2002) [Pubmed]
  20. Selective induction of mucin-3 by hypoxia in intestinal epithelia. Louis, N.A., Hamilton, K.E., Canny, G., Shekels, L.L., Ho, S.B., Colgan, S.P. J. Cell. Biochem. (2006) [Pubmed]
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