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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Your search matched a total of 55 documents. Results 1 - 10.

Homo sapiens
Gene: ... Disease relevance of TREM1 In sharp contrast to the effect by Ad- FDAP12, transgene expression in the liver of soluble form of extracellular domain of TREM- 1 as an antagonist of DAP12 signaling, remarkably inhibited zymosan A- induced granuloma formation at all time points examined. Notably, blockade of TREM- 1... / Synonyms: TREM-1
Mus musculus
Gene: ... High impact information on Trem2 Knockdown of TREM2 in microglia inhibited phagocytosis...- 2, whereas overexpression of TREM2 increased phagocytosis and decreased microglial proinflammatory responses. Here, we show expression of TREM2 in microglia. Here we show that the triggering receptor... / Synonyms: TREM-2; Trem2a; Trem2b
Gallus gallus
Gene: ... High impact information on TREM2 Furthermore, we show that plexin- A1 associates with the triggering receptor expressed on myeloid cells- 2( Trem- 2 ), linking semaphorin- signalling to the immuno- receptor tyrosine- based activation motif( ITAM )- bearing adaptor protein, DAP12.... / Synonyms: TREM-A1; TREM-B1
Homo sapiens
Gene: ... Disease relevance of TREM2 In living human microglia CHME- 5 and glioblastoma T98G cells, activation of TREM2 by its specific antibody induced[ Ca2 +] i responses, documenting its surface expression and functioning. Here we show that loss of function mutations in DAP12 and TREM2 result in an inefficient... / Synonyms: TREM-2; Trem2a; Trem2b
Mus musculus
Gene: ... Disease relevance of Trem1 These data suggest that in vivo modulation of TREM- 1 by sTREM peptide might be a suitable therapeutic tool for the treatment of sepsis. In addition, TREM- 1 mediates the septic shock pathway, and thus represents a potential therapeutic target. The TREM- 1 ligand... / Synonyms: TREM-1
Sus scrofa
Gene: ... Disease relevance of TREM- 1 Moreover, bone marrow cells derived from pigs that were orally challenged with Salmonella enterica serovar Typhimurium showed increases in TREM- 1 at 8 and 24 h post... infection induces TREM- 1 expression. High impact information on TREM- 1 Treating porcine bone marrow cells...
Xenopus (Silurana) tropicalis
Gene: Synonyms: trem-2; trem2a; trem2b
MeSH term: ... . We introduce the term" virulent" Crohn' s disease to describe those patients with most or all... participate in the regulation of Ang- 2 production in sepsis. Biological context of Sepsis TREM- 1: a new... of TREM- 1 protects mice against LPS- induced shock, as well as microbial sepsis caused by live...
Drosophila melanogaster
Homo sapiens
Gene: ... High impact information on CD300LB The second was a three- locus haplotype lying within the first intron of CMRF35A2( TREM5)( TDT P= 0. 04).... / Synonyms: TREM-5; TREM5


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