The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Trem1  -  triggering receptor expressed on myeloid...

Mus musculus

Synonyms: TREM-1, Triggering receptor expressed on myeloid cells 1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Trem1

  • These data suggest that in vivo modulation of TREM-1 by sTREM peptide might be a suitable therapeutic tool for the treatment of sepsis [1].
  • In addition, TREM-1 mediates the septic shock pathway, and thus represents a potential therapeutic target [2].
  • The TREM-1 ligand was expressed on both peritoneal and peripheral neutrophils during experimental peritonitis in mice [3].
  • In septic rats, the TREM-1 peptides improved the hemodynamic status, attenuated the development of lactic acidosis, modulated the production of such proinflammatory cytokines as tumor necrosis factor alpha and interleukin-1beta, and improved survival [3].

High impact information on Trem1

  • To date, signals downstream of the TREM-1 and DAP12 complex in myeloid cells are poorly defined [4].
  • The engagement of triggering receptor expressed on myeloid cells 1 (TREM-1) on macrophages and neutrophils leads to TNF-alpha and IL-8 production and enhances inflammatory responses to microbial products [4].
  • In addition, low levels of NTAL are correlated with decreased and delayed mobilization of Ca(2+) after TREM-1 triggering [4].
  • By analyzing receptor-induced tyrosine phosphorylation patterns, we discovered that the ligation of TREM-1 leads to tyrosine phosphorylation of the non-T cell activation linker (NTAL; also called linker of activation in B cells or LAB) in a myelomonocytic cell line and primary human granulocytes [4].
  • For signal transduction, TREM-1 couples to the ITAM-containing adapter DNAX activation protein of 12 kDa (DAP12) [4].

Biological context of Trem1

  • Analysis of the mouse genome reveals that the gene for TREM-3 lies adjacent to the gene for TREM-1 and in close proximity to a number of other single Ig domain receptors, including TREM-2 [5].
  • The triggering receptor expressed on myeloid cells (TREM) gene cluster encodes a group of transmembrane proteins that are emerging as important components in innate and adaptive immunity [6].
  • Sepsis strongly induced TREM-1 gene expression, which translated into an up-regulation of TREM-1 surface expression on neutrophils and monocytes/macrophages both at the focus on infection as well as distally [7].
  • The DNA elements involved in this tissue-specific and hormone-regulated gene expression are located within 3.2 kbp of 5' flanking region as previously demonstrated by transgenic mice analysis [Tremp, G. L., Boquet, D., Ripoche, M. A., Cognet, M., Yu-Chun, L., Jami, J., Kahn, A. and Daegelen, D. (1989) J. Biol. Chem. 264, 19,904-19,910] [8].
  • 1. Long trem benzene action brings about a permanent decrease in oxidoreductive enzymes and active transport as well as an inactivation of the lysosomal apparatus in liver-cells [9].

Anatomical context of Trem1

  • We recently reported the cloning of two triggering receptors expressed by myeloid cells (TREM), TREM-2a and TREM-2b, which are highly homologous to each other [5].
  • CONCLUSION: These findings suggest that rapid induction of TREM-1 expression on resident peritoneal macrophages and neutrophils by MSU crystals may contribute to the development of acute gout through enhancement of inflammatory responses [10].
  • RESULTS: TREM-1 expression by resident peritoneal macrophages was significantly induced after stimulation with the crystals [10].
  • OBJECTIVE: Triggering receptor expressed on myeloid cells 1 (TREM-1) is a cell surface molecule that was recently identified on monocytes and neutrophils [10].
  • MSU crystals also induced TREM-1 expression in infiltrating leukocytes in a murine air-pouch model of crystal-induced acute inflammation [10].

Associations of Trem1 with chemical compounds

  • In the present study, we investigated the role of TREM-1 in acute inflammation induced by monosodium urate monohydrate (MSU) crystals [10].

Regulatory relationships of Trem1


Other interactions of Trem1


Analytical, diagnostic and therapeutic context of Trem1


  1. A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis. Gibot, S., Kolopp-Sarda, M.N., Béné, M.C., Bollaert, P.E., Lozniewski, A., Mory, F., Levy, B., Faure, G.C. J. Exp. Med. (2004) [Pubmed]
  2. Crystal structure of mouse triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.76 A. Kelker, M.S., Debler, E.W., Wilson, I.A. J. Mol. Biol. (2004) [Pubmed]
  3. Modulation of the triggering receptor expressed on the myeloid cell type 1 pathway in murine septic shock. Gibot, S., Buonsanti, C., Massin, F., Romano, M., Kolopp-Sarda, M.N., Benigni, F., Faure, G.C., Béné, M.C., Panina-Bordignon, P., Passini, N., Lévy, B. Infect. Immun. (2006) [Pubmed]
  4. Non-T Cell Activation Linker (NTAL) Negatively Regulates TREM-1/DAP12-Induced Inflammatory Cytokine Production in Myeloid Cells. Tessarz, A.S., Weiler, S., Zanzinger, K., Angelisová, P., Horejsí, V., Cerwenka, A. J. Immunol. (2007) [Pubmed]
  5. Characterization of TREM-3, an activating receptor on mouse macrophages: definition of a family of single Ig domain receptors on mouse chromosome 17. Chung, D.H., Seaman, W.E., Daws, M.R. Eur. J. Immunol. (2002) [Pubmed]
  6. Trem-like transcript 2 is expressed on cells of the myeloid/granuloid and B lymphoid lineage and is up-regulated in response to inflammation. King, R.G., Herrin, B.R., Justement, L.B. J. Immunol. (2006) [Pubmed]
  7. Surface and soluble triggering receptor expressed on myeloid cells-1: expression patterns in murine sepsis. Gibot, S., Massin, F., Le Renard, P., Béné, M.C., Faure, G.C., Bollaert, P.E., Levy, B. Crit. Care Med. (2005) [Pubmed]
  8. DNase-I hypersensitivity analysis of the L-type pyruvate kinase gene in rats and transgenic mice. Boquet, D., Vaulont, S., Tremp, G., Ripoche, M.A., Daegelen, D., Jami, J., Kahn, A., Raymondjean, M. Eur. J. Biochem. (1992) [Pubmed]
  9. The behaviour of some enzymes in the mouse liver due to chronic benzene intoxication. Kamińska, O., Jonek, J., Kamiński, M., Koehler, B., Konecki, J. Acta Histochem. (1978) [Pubmed]
  10. Induction of triggering receptor expressed on myeloid cells 1 in murine resident peritoneal macrophages by monosodium urate monohydrate crystals. Murakami, Y., Akahoshi, T., Hayashi, I., Endo, H., Kawai, S., Inoue, M., Kondo, H., Kitasato, H. Arthritis Rheum. (2006) [Pubmed]
WikiGenes - Universities