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Trem1  -  triggering receptor expressed on myeloid...

Mus musculus

Synonyms: TREM-1, Triggering receptor expressed on myeloid cells 1
 
 
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Disease relevance of Trem1

  • These data suggest that in vivo modulation of TREM-1 by sTREM peptide might be a suitable therapeutic tool for the treatment of sepsis [1].
  • In addition, TREM-1 mediates the septic shock pathway, and thus represents a potential therapeutic target [2].
  • The TREM-1 ligand was expressed on both peritoneal and peripheral neutrophils during experimental peritonitis in mice [3].
  • In septic rats, the TREM-1 peptides improved the hemodynamic status, attenuated the development of lactic acidosis, modulated the production of such proinflammatory cytokines as tumor necrosis factor alpha and interleukin-1beta, and improved survival [3].
 

High impact information on Trem1

  • To date, signals downstream of the TREM-1 and DAP12 complex in myeloid cells are poorly defined [4].
  • The engagement of triggering receptor expressed on myeloid cells 1 (TREM-1) on macrophages and neutrophils leads to TNF-alpha and IL-8 production and enhances inflammatory responses to microbial products [4].
  • In addition, low levels of NTAL are correlated with decreased and delayed mobilization of Ca(2+) after TREM-1 triggering [4].
  • By analyzing receptor-induced tyrosine phosphorylation patterns, we discovered that the ligation of TREM-1 leads to tyrosine phosphorylation of the non-T cell activation linker (NTAL; also called linker of activation in B cells or LAB) in a myelomonocytic cell line and primary human granulocytes [4].
  • For signal transduction, TREM-1 couples to the ITAM-containing adapter DNAX activation protein of 12 kDa (DAP12) [4].
 

Biological context of Trem1

  • Analysis of the mouse genome reveals that the gene for TREM-3 lies adjacent to the gene for TREM-1 and in close proximity to a number of other single Ig domain receptors, including TREM-2 [5].
  • The triggering receptor expressed on myeloid cells (TREM) gene cluster encodes a group of transmembrane proteins that are emerging as important components in innate and adaptive immunity [6].
  • Sepsis strongly induced TREM-1 gene expression, which translated into an up-regulation of TREM-1 surface expression on neutrophils and monocytes/macrophages both at the focus on infection as well as distally [7].
  • The DNA elements involved in this tissue-specific and hormone-regulated gene expression are located within 3.2 kbp of 5' flanking region as previously demonstrated by transgenic mice analysis [Tremp, G. L., Boquet, D., Ripoche, M. A., Cognet, M., Yu-Chun, L., Jami, J., Kahn, A. and Daegelen, D. (1989) J. Biol. Chem. 264, 19,904-19,910] [8].
  • 1. Long trem benzene action brings about a permanent decrease in oxidoreductive enzymes and active transport as well as an inactivation of the lysosomal apparatus in liver-cells [9].
 

Anatomical context of Trem1

  • We recently reported the cloning of two triggering receptors expressed by myeloid cells (TREM), TREM-2a and TREM-2b, which are highly homologous to each other [5].
  • CONCLUSION: These findings suggest that rapid induction of TREM-1 expression on resident peritoneal macrophages and neutrophils by MSU crystals may contribute to the development of acute gout through enhancement of inflammatory responses [10].
  • RESULTS: TREM-1 expression by resident peritoneal macrophages was significantly induced after stimulation with the crystals [10].
  • OBJECTIVE: Triggering receptor expressed on myeloid cells 1 (TREM-1) is a cell surface molecule that was recently identified on monocytes and neutrophils [10].
  • MSU crystals also induced TREM-1 expression in infiltrating leukocytes in a murine air-pouch model of crystal-induced acute inflammation [10].
 

Associations of Trem1 with chemical compounds

  • In the present study, we investigated the role of TREM-1 in acute inflammation induced by monosodium urate monohydrate (MSU) crystals [10].
 

Regulatory relationships of Trem1

 

Other interactions of Trem1

 

Analytical, diagnostic and therapeutic context of Trem1

References

  1. A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis. Gibot, S., Kolopp-Sarda, M.N., Béné, M.C., Bollaert, P.E., Lozniewski, A., Mory, F., Levy, B., Faure, G.C. J. Exp. Med. (2004) [Pubmed]
  2. Crystal structure of mouse triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.76 A. Kelker, M.S., Debler, E.W., Wilson, I.A. J. Mol. Biol. (2004) [Pubmed]
  3. Modulation of the triggering receptor expressed on the myeloid cell type 1 pathway in murine septic shock. Gibot, S., Buonsanti, C., Massin, F., Romano, M., Kolopp-Sarda, M.N., Benigni, F., Faure, G.C., Béné, M.C., Panina-Bordignon, P., Passini, N., Lévy, B. Infect. Immun. (2006) [Pubmed]
  4. Non-T Cell Activation Linker (NTAL) Negatively Regulates TREM-1/DAP12-Induced Inflammatory Cytokine Production in Myeloid Cells. Tessarz, A.S., Weiler, S., Zanzinger, K., Angelisová, P., Horejsí, V., Cerwenka, A. J. Immunol. (2007) [Pubmed]
  5. Characterization of TREM-3, an activating receptor on mouse macrophages: definition of a family of single Ig domain receptors on mouse chromosome 17. Chung, D.H., Seaman, W.E., Daws, M.R. Eur. J. Immunol. (2002) [Pubmed]
  6. Trem-like transcript 2 is expressed on cells of the myeloid/granuloid and B lymphoid lineage and is up-regulated in response to inflammation. King, R.G., Herrin, B.R., Justement, L.B. J. Immunol. (2006) [Pubmed]
  7. Surface and soluble triggering receptor expressed on myeloid cells-1: expression patterns in murine sepsis. Gibot, S., Massin, F., Le Renard, P., Béné, M.C., Faure, G.C., Bollaert, P.E., Levy, B. Crit. Care Med. (2005) [Pubmed]
  8. DNase-I hypersensitivity analysis of the L-type pyruvate kinase gene in rats and transgenic mice. Boquet, D., Vaulont, S., Tremp, G., Ripoche, M.A., Daegelen, D., Jami, J., Kahn, A., Raymondjean, M. Eur. J. Biochem. (1992) [Pubmed]
  9. The behaviour of some enzymes in the mouse liver due to chronic benzene intoxication. Kamińska, O., Jonek, J., Kamiński, M., Koehler, B., Konecki, J. Acta Histochem. (1978) [Pubmed]
  10. Induction of triggering receptor expressed on myeloid cells 1 in murine resident peritoneal macrophages by monosodium urate monohydrate crystals. Murakami, Y., Akahoshi, T., Hayashi, I., Endo, H., Kawai, S., Inoue, M., Kondo, H., Kitasato, H. Arthritis Rheum. (2006) [Pubmed]
 
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