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Chemical Compound Review:

PBDP 8-phenoxy-7,9-dioxa-8$l^{5}...

Synonyms: Phenylsalioxon, CCRIS 6422, AG-F-44921, CTK4I3814, AR-1E4753, ...

Mentzschel, A. et al., Mentzschel, A. et al.

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Disease relevance of Phenyl saligenin cyclic phosphate

In a previous paper we reported that 2-phenoxy-4H-1,3,2-benzodioxaphosphorin 2-oxide is mutagenic in Salmonella typhimurium TA100 and forms DNA adducts in incubations with nucleotides, nucleosides and isolated DNA [1].
In both bacteria and hepatoma cells two DNA adducts could be detected after treatment with 2-phenoxy-4H-1,3,2-benzodioxaphosphorin 2-oxide [1].

High impact information on Phenyl saligenin cyclic phosphate

Adducts formed with nucleosides in calf thymus DNA reacted with 2-phenoxy-4H-1,3,2-benzodioxaphosphorin 2-oxide in vitro were detected by the 32P-postlabeling technique and identified by comparison with synthetic references [2].

Anatomical context of Phenyl saligenin cyclic phosphate

The formation of N-2-(o-hydroxybenzyl)-deoxyguanosine, N-3-(o-hydroxybenzyl)deoxyuridine, and N-1-(o-hydroxybenzyl)deoxyadenosine was also demonstrated when 2-phenoxy-4H-1,3,2-benzodioxaphosphorin 2-oxide was incubated with calf thymus DNA [2].

References

DNA adduct formation in Salmonella typhimurium, cultured liver cells and in Fischer 344 rats treated with o-tolyl phosphates and their metabolites. Mentzschel, A., Vamvakas, S., Dekant, W., Henschler, D. Carcinogenesis (1993) [Pubmed]
Genotoxicity of neurotoxic triaryl phosphates: identification of DNA adducts of the ultimate metabolites, saligenin phosphates. Mentzschel, A., Schmuck, G., Dekant, W., Henschler, D. Chem. Res. Toxicol. (1993) [Pubmed]

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