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Chemical Compound Review:

CHEMBL81419 1-(4-nitrosophenyl)-2-phenyl- hydrazine

Synonyms: CCRIS 1066, LS-77464, BRN 1842271, AC1L32LS, 6530-27-4, ...

Hashimoto, Y. et al., Hashimoto, Y. et al., Ohnishi, S. et al.

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Disease relevance of CCRIS 1066

The mutagenicities of 4-aminoazobenzene (AAB), N-hydroxy-4-aminoazobenzene, 4-nitroazobenzene, and their 2-, 3-, 4'-methoxyl and 2,5-dimethoxyl derivatives, and 2- and 3-methoxy-4-nitrosoazobenzene were examined on Salmonella typhimurium TA98 and TA100 [1].

High impact information on CCRIS 1066

The DAB metabolite N-hydroxy-4-aminoazobenzene (N-OH-AAB) was found to cause Cu(II)-mediated DNA damage, including 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) formation [2].
The activation process of N-hydroxy-4-aminoazobenzene (N-OH-AAB) dyes, proximate mutagenic or carcinogenic metabolites of AAB dyes, to the ultimate mutagenic or carcinogenic metabolites was studied by the use of an amino acid conjugation (aminoacylation) system catalyzed by yeast seryl-tRNA synthetase and [3H]ATP [3].

References

Mutagenicity of 4-aminoazobenzene, N-hydroxy-4-aminoazobenzene, 4-nitrosoazobenzene, 4-nitroazobenzene, and their ring methoxylated derivatives on Salmonella. Hashimoto, Y., Watanabe, H.K., Degawa, M. Gann = Gan. (1981) [Pubmed]
Oxidative DNA damage induced by an N-hydroxy metabolite of carcinogenic 4-dimethylaminoazobenzene. Ohnishi, S., Murata, M., Degawa, M., Kawanishi, S. Jpn. J. Cancer Res. (2001) [Pubmed]
Amino acid conjugation of N-hydroxy-4-aminoazobenzene dyes: a possible activation process of carcinogenic 4-aminoazobenzene dyes to the ultimate mutagenic or carcinogenic metabolites. Hashimoto, Y., Degawa, M., Watanabe, H.K., Tada, M. Gann = Gan. (1981) [Pubmed]

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