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Chemical Compound Review: 

aceanthrylen     aceanthrylene

Synonyms: Aceanthrylene, CCRIS 1998, AG-E-47909, CHEBI:33086, LS-7848, ...
 
 
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Disease relevance of aceanthrylene

  • Aceanthrylene, a non-alternant cyclopenta-fused hydrocarbon, was shown to be weakly mutagenic without S9 and strongly mutagenic with S9 in the Ames Salmonella plate incorporation assay [1].
 

High impact information on aceanthrylene

  • Saturation of the cyclopenta rings or methylation at the 6-position of AA reduced, but did not eliminate, mutagenicity measured in the absence of PMS [2].
  • The bay region tetrol 7,8,9,10-tetrahydroxy-7,8,9,10-tetrahydrobenz[j] aceanthrylene was observed, implying further bay-region metabolism; re-aromatization of the benzo ring to benz[j]aceanthrylene-9,10-diol also occurred [3].

References

  1. Bacterial mutagenicity of aceanthrylene: a novel cyclopenta-fused polycyclic aromatic hydrocarbon of low molecular weight. Kohan, M.J., Sangaiah, R., Ball, L.M., Gold, A. Mutat. Res. (1985) [Pubmed]
  2. Mutagenicity of cyclopenta-fused polynuclear aromatic hydrocarbons and a non-polar fraction from a fuel combustion sample in a Salmonella forward mutation assay without exogenous metabolic activation. Busby, W.F., Smith, H., Plummer, E.F., Lafleur, A.L., Mulder, P.P., Boere, B.B., Cornelisse, J., Lugtenburg, J. Mutat. Res. (1997) [Pubmed]
  3. Activation and metabolism of benz[j]aceanthrylene-9,10-dihydrodiol, the precursor to bay-region metabolism of the genotoxic cyclopenta-PAH benz[j]aceanthrylene. Newcomb, K.O., Sangaiah, R., Gold, A., Ball, L.M. Mutat. Res. (1993) [Pubmed]
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