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Chemical Compound Review:

MUSKONE 3-methylcyclopentadecan-1-one

Synonyms: Muscone, Methylexaltone, SureCN230871, Moschus ketone, HSDB 1219, ...

Tanaka, E. et al., Kraft, P. et al.

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Psychiatry related information on MUSKONE

While the enantioselectivity of odor perception is strong evidence for the key role of proteinogenic receptors in the molecular mechanism of olfaction, the quantitative and qualitative odor differences of enantiomers are often not very pronounced, as in the case of muscone (17/26) [1].

High impact information on MUSKONE

In the in vitro study, we found that the content of cytochrome P-450, and activities of aminopyrine, N-demethylase, aniline hydroxylase and delta-aminolevulinic acid (ALA) synthetase were significantly increased as compared to the controls in both male and female rats treated with muscone (75 and 150 mg/kg) [2].

References

Enantioselectivity of the musk odor sensation. Kraft, P., Fráter, G. Chirality. (2001) [Pubmed]
Induction of cytochrome P-450 and related drug-oxidizing activities in muscone (3-methylcyclopentadecanone)-treated rats. Tanaka, E., Kurata, N., Kohno, M., Yoshida, T., Kuroiwa, Y. Biochem. Pharmacol. (1987) [Pubmed]

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