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Chemical Compound Review

Cosmos Red     4-amino-3-[4-[4-(1-amino-4- sulfo...

Synonyms: CHEMBL116955, Cotton Red B, Cotton Red C, Direct Red R, Direct Red Y, ...
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Disease relevance of Congo red

  • The Hms(+) phenotype of Yersinia pestis promotes the binding of haemin or Congo red (CR) to the cell surface at temperatures below 34 degrees C. We previously demonstrated that temperature regulation of the Hms(+) phenotype is not controlled at the level of transcription [1].

High impact information on Congo red

  • Mutations in hmsP caused formation of red colonies on CR plates at 26 degrees C and 37 degrees C. Strains complemented with hmsP(+) on a plasmid form white colonies at both temperatures [1].


  1. HmsP, a putative phosphodiesterase, and HmsT, a putative diguanylate cyclase, control Hms-dependent biofilm formation in Yersinia pestis. Kirillina, O., Fetherston, J.D., Bobrov, A.G., Abney, J., Perry, R.D. Mol. Microbiol. (2004) [Pubmed]
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