Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Linifanib 1-[4-(3-amino-1H-indazol-4- yl)phenyl]-3-(2...

Synonyms: QCR-97, Kinome_532, PubChem22400, ABT-869, SureCN93804, ...

Shankar, D.B. et al., Jasinghe, V.J. et al.

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Associations of Linifanib with other chemical compounds

In tumors, ABT-869 inhibited FLT3 phosphorylation, induced apoptosis (transferase-mediated dUTP nick-end labeling [TUNEL]) and decreased proliferation (Ki67) [1].
Rapamycin, but not ABT-869, inhibited in vitro growth of Huh7 and SK-HEP-1 HCC cells in a dose dependant manner [2].

References

ABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia. Shankar, D.B., Li, J., Tapang, P., Owen McCall, J., Pease, L.J., Dai, Y., Wei, R.Q., Albert, D.H., Bouska, J.J., Osterling, D.J., Guo, J., Marcotte, P.A., Johnson, E.F., Soni, N., Hartandi, K., Michaelides, M.R., Davidsen, S.K., Priceman, S.J., Chang, J.C., Rhodes, K., Shah, N., Moore, T.B., Sakamoto, K.M., Glaser, K.B. Blood (2007) [Pubmed]
ABT-869, a multi-targeted tyrosine kinase inhibitor, in combination with rapamycin is effective for subcutaneous hepatocellular carcinoma xenograft. Jasinghe, V.J., Xie, Z., Zhou, J., Khng, J., Poon, L.F., Senthilnathan, P., Glaser, K.B., Albert, D.H., Davidsen, S.K., Chen, C.S. J. Hepatol. (2008) [Pubmed]

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