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Chemical Compound Review:

dUTP [[[(2R,3S,5R)-5-(2,4- dioxopyrimidin-1-yl)...

Synonyms: deoxy-UTP, N(4) MO-Dctp, CHEMBL374361, CHEBI:17625, HMDB01191, ...

Zhu, M.Y. et al., Martin De Las Mulas, J. et al., Kawano, H. et al., Huser, C.A. et al., Kim, H.G. et al., et al.

Zhu, Wang, Bissette,

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High impact information on deoxy-UTP

The decreased osteoblast cell number was accounted by an increase in apoptosis, as determined by DNA fragmentation measured by transferase-mediated digoxigenin-deoxyuridine triphosphate (dUTP) in situ nick-end labeling (TUNEL) reaction [1].
Spectrophotometric measurements of lactate dehydrogenase activities, beta-tubulin III immunocytochemical staining, terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate (dUTP) nick-end-labeling assay (TUNEL) labeling and caspase-3 assays were carried out to detect cell damage or possible involved mechanisms [2].
To elucidate the signalling mechanisms involved in impact-induced cell death measured by terminal deoxynucleotidyl transferase-deoxyuridine triphosphate (dUTP) nick-end labelling (TUNEL), cartilage discs were incubated with specific caspase-3, -8 and -9 inhibitors prior to impact [3].
Cell division was detected with proliferating cell nuclear antigen (PCNA) immunohistochemistry, and apoptosis was detected with terminal deoxynucleotidyl transferase (TdT)-mediated deoxyuridine triphosphate (dUTP) in-situ nick-end labeling (TUNEL) study [4].

Anatomical context of deoxy-UTP

The presence of apoptotic cell death was evaluated in routinely processed tissue samples of 39 neoplasms of the skin and subcutaneous tissues of the dog using the method of terminal deoxynucleotidyl transferase (T d T) mediated deoxyuridine-5'-triphosphate (d UTP)-biotin nick end labelling (TUNEL) [5].

Analytical, diagnostic and therapeutic context of deoxy-UTP

DNA fragmentation, measured by the terminal deoxynucleotidyl transferase (TdT)-mediated deoxyuridine-5'-triphosphate (dUTP)-biotin nick end labeling method, was observed in only 1 patient, who had received radiotherapy just before biopsy, and none of the patients showed bcl-2 positivity [6].

References

CCAAT/Enhancer-binding protein homologous protein (CHOP) decreases bone formation and causes osteopenia. Pereira, R.C., Stadmeyer, L.E., Smith, D.L., Rydziel, S., Canalis, E. Bone (2007) [Pubmed]
Neuroprotective effects of agmatine against cell damage caused by glucocorticoids in cultured rat hippocampal neurons. Zhu, M.Y., Wang, W.P., Bissette, G. Neuroscience (2006) [Pubmed]
Inhibition of caspase-9 reduces chondrocyte apoptosis and proteoglycan loss following mechanical trauma. Huser, C.A., Peacock, M., Davies, M.E. Osteoarthr. Cartil. (2006) [Pubmed]
Serial microscopic changes in cell proliferation and apoptosis in obstructed ureter of rat. Kim, H.G., Paick, S.H., Kwak, C., Kim, H.H., Lho, Y.S. J. Endourol. (2006) [Pubmed]
Apoptosis and mitosis in tumours of the skin and subcutaneous tissues of the dog. Martin De Las Mulas, J., Millan, Y., Ruiz-Villamor, E., Bautista, M.J., Rollon, E., Espinosa De Los Monteros, A. Res. Vet. Sci. (1999) [Pubmed]
Immunohistochemical study of giant cell in glioblastoma. Kawano, H., Kubota, T., Sato, K., Goya, T., Arikawa, S., Wakisaka, S. Clin. Neuropathol. (1995) [Pubmed]

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