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Chemical Compound Review

dUTP     [[[(2R,3S,5R)-5-(2,4- dioxopyrimidin-1-yl)...

Synonyms: deoxy-UTP, N(4) MO-Dctp, CHEMBL374361, CHEBI:17625, HMDB01191, ...
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High impact information on deoxy-UTP

  • The decreased osteoblast cell number was accounted by an increase in apoptosis, as determined by DNA fragmentation measured by transferase-mediated digoxigenin-deoxyuridine triphosphate (dUTP) in situ nick-end labeling (TUNEL) reaction [1].
  • Spectrophotometric measurements of lactate dehydrogenase activities, beta-tubulin III immunocytochemical staining, terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate (dUTP) nick-end-labeling assay (TUNEL) labeling and caspase-3 assays were carried out to detect cell damage or possible involved mechanisms [2].
  • To elucidate the signalling mechanisms involved in impact-induced cell death measured by terminal deoxynucleotidyl transferase-deoxyuridine triphosphate (dUTP) nick-end labelling (TUNEL), cartilage discs were incubated with specific caspase-3, -8 and -9 inhibitors prior to impact [3].
  • Cell division was detected with proliferating cell nuclear antigen (PCNA) immunohistochemistry, and apoptosis was detected with terminal deoxynucleotidyl transferase (TdT)-mediated deoxyuridine triphosphate (dUTP) in-situ nick-end labeling (TUNEL) study [4].

Anatomical context of deoxy-UTP


Analytical, diagnostic and therapeutic context of deoxy-UTP


  1. CCAAT/Enhancer-binding protein homologous protein (CHOP) decreases bone formation and causes osteopenia. Pereira, R.C., Stadmeyer, L.E., Smith, D.L., Rydziel, S., Canalis, E. Bone (2007) [Pubmed]
  2. Neuroprotective effects of agmatine against cell damage caused by glucocorticoids in cultured rat hippocampal neurons. Zhu, M.Y., Wang, W.P., Bissette, G. Neuroscience (2006) [Pubmed]
  3. Inhibition of caspase-9 reduces chondrocyte apoptosis and proteoglycan loss following mechanical trauma. Huser, C.A., Peacock, M., Davies, M.E. Osteoarthr. Cartil. (2006) [Pubmed]
  4. Serial microscopic changes in cell proliferation and apoptosis in obstructed ureter of rat. Kim, H.G., Paick, S.H., Kwak, C., Kim, H.H., Lho, Y.S. J. Endourol. (2006) [Pubmed]
  5. Apoptosis and mitosis in tumours of the skin and subcutaneous tissues of the dog. Martin De Las Mulas, J., Millan, Y., Ruiz-Villamor, E., Bautista, M.J., Rollon, E., Espinosa De Los Monteros, A. Res. Vet. Sci. (1999) [Pubmed]
  6. Immunohistochemical study of giant cell in glioblastoma. Kawano, H., Kubota, T., Sato, K., Goya, T., Arikawa, S., Wakisaka, S. Clin. Neuropathol. (1995) [Pubmed]
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