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Chemical Compound Review

ACMC-1C6VL     N-chrysen-6-ylhydroxylamine

Synonyms: AG-D-34729, AC1L3GRH, CTK4A8743, 114451-10-4, N-Hydroxy-6-chrysenamine, ...
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High impact information on N-Hydroxy-6-aminochrysene


Analytical, diagnostic and therapeutic context of N-Hydroxy-6-aminochrysene

  • HPLC analyses of enzymatic hydrolysates of the explant DNA indicated that 11 of 13 cases contained adducts with retention times identical to those of adducts derived from trans-1,2-dihydroxy-1,2-dihydro-6-aminochrysene or N-hydroxy-6-aminochrysene [2].


  1. Identification of C8-modified deoxyinosine and N2- and C8-modified deoxyguanosine as major products of the in vitro reaction of N-hydroxy-6-aminochrysene with DNA and the formation of these adducts in isolated rat hepatocytes treated with 6-nitrochrysene and 6-aminochrysene. Delclos, K.B., Miller, D.W., Lay, J.O., Casciano, D.A., Walker, R.P., Fu, P.P., Kadlubar, F.F. Carcinogenesis (1987) [Pubmed]
  2. Metabolic activation of 6-nitrochrysene in explants of human bronchus and in isolated rat hepatocytes. Delclos, K.B., el-Bayoumy, K., Casciano, D.A., Walker, R.P., Kadlubar, F.F., Hecht, S.S., Shivapurkar, N., Mandal, S., Stoner, G.D. Cancer Res. (1989) [Pubmed]
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