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Chemical Compound Review:

ACMC-1C6VL N-chrysen-6-ylhydroxylamine

Synonyms: AG-D-34729, AC1L3GRH, CTK4A8743, 114451-10-4, N-Hydroxy-6-chrysenamine, ...

Delclos, K.B. et al., Delclos, K.B. et al.

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High impact information on N-Hydroxy-6-aminochrysene

Identification of C8-modified deoxyinosine and N2- and C8-modified deoxyguanosine as major products of the in vitro reaction of N-hydroxy-6-aminochrysene with DNA and the formation of these adducts in isolated rat hepatocytes treated with 6-nitrochrysene and 6-aminochrysene [1].

Analytical, diagnostic and therapeutic context of N-Hydroxy-6-aminochrysene

HPLC analyses of enzymatic hydrolysates of the explant DNA indicated that 11 of 13 cases contained adducts with retention times identical to those of adducts derived from trans-1,2-dihydroxy-1,2-dihydro-6-aminochrysene or N-hydroxy-6-aminochrysene [2].

References

Identification of C8-modified deoxyinosine and N2- and C8-modified deoxyguanosine as major products of the in vitro reaction of N-hydroxy-6-aminochrysene with DNA and the formation of these adducts in isolated rat hepatocytes treated with 6-nitrochrysene and 6-aminochrysene. Delclos, K.B., Miller, D.W., Lay, J.O., Casciano, D.A., Walker, R.P., Fu, P.P., Kadlubar, F.F. Carcinogenesis (1987) [Pubmed]
Metabolic activation of 6-nitrochrysene in explants of human bronchus and in isolated rat hepatocytes. Delclos, K.B., el-Bayoumy, K., Casciano, D.A., Walker, R.P., Kadlubar, F.F., Hecht, S.S., Shivapurkar, N., Mandal, S., Stoner, G.D. Cancer Res. (1989) [Pubmed]

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