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Chemical Compound Review

deoxyguanosine     2-amino-9-[4-hydroxy-5...

Synonyms: ACMC-1C8JT, AG-D-37261, D8415_SIGMA, NSC-22837, SureCN10068103, ...
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Disease relevance of deoxyguanosine


High impact information on deoxyguanosine


Chemical compound and disease context of deoxyguanosine


Biological context of deoxyguanosine

  • The promoter region of the chicken adult beta-globin gene contains a sequence of 16 deoxyguanosine residues located at a nucleosome boundary in tissues where the gene is inactive [15].
  • The studies also indicated that H2O2 formed hydroxyl radical (.OH) intracellularly, which appeared to be the most likely free radical responsible for DNA damage: .OH was detected in cells exposed to H2O2; the DNA base, deoxyguanosine, was hydroxylated in cells exposed to H2O2; and intracellular iron was essential for induction of DNA strand breaks [16].
  • At saturation, anti-diol-epoxide had covalently modified 1.5% of the total deoxyguanosine residues in naked DNA, and this was reduced to 29 and 15% of this level in saturating the available anti-diol-epoxide-binding sites in chromosomes or chromatin, respectively [17].
  • We show that cytostatic 2'-deoxyguanosine concentrations cause G1-phase arrest in PNP-inhibited T lymphoblasts, regardless of their hypoxanthine guanine phosphoribosyltransferase status [11].
  • The effects on leukemia cells were mediated by the cellular phosphorylation of deoxyguanosine and the accumulation of dGTP, an inhibitor of ribonucleotide diphosphate reductase [18].

Anatomical context of deoxyguanosine

  • Inhibition of suppressor T-cell development following deoxyguanosine administration [19].
  • Recent transplantation studies suggest that thymic epithelium, derived by organ culturing fetal mouse thymus in the presence of deoxyguanosine, survives in an allogeneic host environment despite the continued expression of MHC donor antigens, but fails to induce allotolerance [20].
  • It also interfered with the differentiation of fetal liver cells or fetal thymocytes within deoxyguanosine-treated thymic lobes, but did not affect thymocyte development in intact cultured fetal thymic lobes [21].
  • Cultured leukemic T and null lymphocytes are highly sensitive to growth inhibition by thymidine, as well as the other deoxynucleosides, deoxyguanosine and deoxyadenosine [22].
  • The latter infectants had PNP activities eight times the level of 0.74 mumol/hr per mg of protein observed in normal skin fibroblasts, enabling rapid metabolism of exogenous deoxyguanosine, the cytotoxic metabolite that accumulates in the plasma of PNP-deficient patients [23].

Associations of deoxyguanosine with other chemical compounds


Gene context of deoxyguanosine


Analytical, diagnostic and therapeutic context of deoxyguanosine


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  2. Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA. Tomasz, M., Lipman, R., Chowdary, D., Pawlak, J., Verdine, G.L., Nakanishi, K. Science (1987) [Pubmed]
  3. A unique deoxyguanosine triphosphatase is responsible for the optA1 phenotype of Escherichia coli. Beauchamp, B.B., Richardson, C.C. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  4. Inhibition of the replication of hepatitis B virus by the carbocyclic analogue of 2'-deoxyguanosine. Price, P.M., Banerjee, R., Acs, G. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
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  8. Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues. Kuchino, Y., Mori, F., Kasai, H., Inoue, H., Iwai, S., Miura, K., Ohtsuka, E., Nishimura, S. Nature (1987) [Pubmed]
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  17. Human fibroblast chromatin states as effectors of the DNA-binding characteristics of benzo[a]pyrene anti-7,8-dihydrodiol 9,10-epoxide and two nonalkylating DNA-binding molecules. Warner, M.R., Iannaccone, P., Fahl, W.E. J. Natl. Cancer Inst. (1986) [Pubmed]
  18. Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes. Kicska, G.A., Long, L., Hörig, H., Fairchild, C., Tyler, P.C., Furneaux, R.H., Schramm, V.L., Kaufman, H.L. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  19. Inhibition of suppressor T-cell development following deoxyguanosine administration. Dosch, H.M., Mansour, A., Cohen, A., Shore, A., Gelfand, E.W. Nature (1980) [Pubmed]
  20. Thymic epithelium and the induction of transplantation tolerance in nude mice. Jordan, R.K., Robinson, J.H., Hopkinson, N.A., House, K.C., Bentley, A.L. Nature (1985) [Pubmed]
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  22. Ecto-adenosine triphosphatase deficiency in cultured human T and null leukemic lymphocytes. A biochemical basis for thymidine sensitivity. Fox, R.M., Piddington, S.K., Tripp, E.H., Tattersall, M.H. J. Clin. Invest. (1981) [Pubmed]
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