The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Chrysenex     chrysen-6-amine

Synonyms: Chrysonex, CCRIS 755, CHEMBL313154, A47052_ALDRICH, ACMC-20am08, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Chrysenex

  • Here we further examined the roles of human liver P450 enzymes and the mechanism of activation of 6-aminochrysene by rat and human P450 enzymes in the Salmonella tester strains [1].

High impact information on Chrysenex


Biological context of Chrysenex


Anatomical context of Chrysenex


Associations of Chrysenex with other chemical compounds


Gene context of Chrysenex

  • Inclusion of purified rat epoxide hydrolase to the reconstituted system containing rat and human P4501A enzymes caused a decrease in the rates of 6-aminochrysene activation.(ABSTRACT TRUNCATED AT 400 WORDS)[1]

Analytical, diagnostic and therapeutic context of Chrysenex

  • 2. The decline in blood levels of the antitumoral agent 6-aminochrysene was due to its distribution rather than to metabolism to polar metabolites, during liver perfusion experiments [6].


  1. Roles of different forms of cytochrome P450 in the activation of the promutagen 6-aminochrysene to genotoxic metabolites in human liver microsomes. Yamazaki, H., Mimura, M., Oda, Y., Inui, Y., Shiraga, T., Iwasaki, K., Guengerich, F.P., Shimada, T. Carcinogenesis (1993) [Pubmed]
  2. Metabolism and DNA binding of the environmental colon carcinogen 6-nitrochrysene in rats. Chae, Y.H., Delclos, K.B., Blaydes, B., el-Bayoumy, K. Cancer Res. (1996) [Pubmed]
  3. Effects of cytochrome P1-450 inducers on the cell-surface receptors for epidermal growth factor, phorbol 12,13-dibutyrate, or insulin of cultured mouse hepatoma cells. Kärenlampi, S.O., Eisen, H.J., Hankinson, O., Nebert, D.W. J. Biol. Chem. (1983) [Pubmed]
  4. Role of human N-acetyltransferases, NAT1 or NAT2, in genotoxicity of nitroarenes and aromatic amines in Salmonella typhimurium NM6001 and NM6002. Oda, Y., Yamazaki, H., Shimada, T. Carcinogenesis (1999) [Pubmed]
  5. Identification of C8-modified deoxyinosine and N2- and C8-modified deoxyguanosine as major products of the in vitro reaction of N-hydroxy-6-aminochrysene with DNA and the formation of these adducts in isolated rat hepatocytes treated with 6-nitrochrysene and 6-aminochrysene. Delclos, K.B., Miller, D.W., Lay, J.O., Casciano, D.A., Walker, R.P., Fu, P.P., Kadlubar, F.F. Carcinogenesis (1987) [Pubmed]
  6. 6-Aminochrysene kinetics in isolated perfused liver. Russo, R., Bartosek, I., Villa, S., Guaitani, A., Garattini, S. Xenobiotica (1976) [Pubmed]
  7. Black tea intake modulates the excretion of urinary mutagens in rats exposed to 6-aminochrysene: induction of cytochromes P450 by 6-aminochrysene in the rat. Yoxall, V., Umachandran, M., Wilson, J., Kentish, P., Ioannides, C. Mutagenesis (2005) [Pubmed]
  8. Effects of 6-aminochrysene on liver microsomal enzyme activity. Russo, R., Bartosek, I., Villa, S., Guaitani, A., Garattini, S. Xenobiotica (1976) [Pubmed]
  9. Bioactivation of 6-aminochrysene by animal and human hepatic preparations: contributions of microsomal and cytosolic enzyme systems. Marczylo, T., Ioannides, C. Mutagenesis (1994) [Pubmed]
  10. The role of intestinal microflora in the metabolic activation of 6-nitrochrysene to DNA-binding derivatives in mice. Delclos, K.B., Cerniglia, C.E., Dooley, K.L., Campbell, W.L., Franklin, W., Walker, R.P. Toxicology (1990) [Pubmed]
  11. Quantitative microspectrofluorimetry study of the "blocking effect" of 6-aminochrysene on benzo[a]pyrene metabolism using single living cells. Lahmy, S., Salmon, J.M., Viallet, P. Toxicology (1984) [Pubmed]
  12. Biological activity of tobacco smoke and tobacco smoke-related chemicals. Kouri, R.E., Rude, T.H., Curren, R.D., Brandt, K.R., Sosnowski, R.G., Schechtman, L.M., Benedict, W.F., Henry, C.J. Environ. Health Perspect. (1979) [Pubmed]
  13. Mutation induction and DNA adduct formation in Chinese hamster ovary cells treated with 6-nitrochrysene, 6-aminochrysene and their metabolites. Delclos, K.B., Heflich, R.H. Mutat. Res. (1992) [Pubmed]
  14. Mutagenicity, metabolism and DNA adduct formation of 6-nitrochrysene in Salmonella typhimurium. el-Bayoumy, K., Delclos, K.B., Heflich, R.H., Walker, R., Shiue, G.H., Hecht, S.S. Mutagenesis (1989) [Pubmed]
  15. Products formed from the in vitro reaction of metabolites of 3-aminochrysene with calf thymus DNA. Herreno-Saenz, D., Evans, F.E., Lai, C.C., Abian, J., Fu, P.P., Delclos, K.B. Chem. Biol. Interact. (1993) [Pubmed]
WikiGenes - Universities