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Chemical Compound Review: 

Inhibitor 1     2-[methyl-(4- phenylphenyl)carbonyl...

Synonyms: AGN-PC-00AZ5T, CHEMBL199572, 2-[methyl-(4-phenylbenzoyl)amino]benzoic Acid
 
 
 
 
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Gene context of Inhibitor 1

  • In biochemical assays the function of Cdk5-dependent phosphorylation of inhibitor-1 at Ser6 and Ser67 was demonstrated to be an intramolecular impairment of the ability of inhibitor-1 to be dephosphorylated at Thr35; this effect was recapitulated in two systems in vivo [1].

References

  1. Regulation of protein phosphatase inhibitor-1 by cyclin-dependent kinase 5. Nguyen, C., Nishi, A., Kansy, J.W., Fernandez, J., Hayashi, K., Gillardon, F., Hemmings, H.C., Nairn, A.C., Bibb, J.A. J. Biol. Chem. (2007) [Pubmed]
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