Gene Review:
Cdk5 - cyclin-dependent kinase 5
Rattus norvegicus
Synonyms:
Cdkn5, Cell division protein kinase 5, Cyclin-dependent-like kinase 5, Serine/threonine-protein kinase PSSALRE, TPKII catalytic subunit, ...
- Protein kinase CK2 is an inhibitor of the neuronal Cdk5 kinase. Lim, A.C., Hou, Z., Goh, C.P., Qi, R.Z. J. Biol. Chem. (2004)
- Aspirin provides cyclin-dependent kinase 5-dependent protection against subsequent hypoxia/reoxygenation damage in culture. Vartiainen, N., Keksa-Goldsteine, V., Goldsteins, G., Koistinaho, J. J. Neurochem. (2002)
- Amyloid-beta-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression. Liu, T., Perry, G., Chan, H.W., Verdile, G., Martins, R.N., Smith, M.A., Atwood, C.S. J. Neurochem. (2004)
- Developmental alteration of the expression and kinase activity of cyclin-dependent kinase 5 (Cdk5)/p35nck5a in the rat retina. Hirooka, K., Tomizawa, K., Matsui, H., Tokuda, M., Itano, T., Hasegawa, E., Wang, J.H., Hatase, O. J. Neurochem. (1996)
- Insulin-like growth factor-1 affects expressions of cyclin-dependent kinase 5 and its activator p35 in reperfused rat brain. Wang, J.M., Hayashi, T., Zhang, W.R., Sakai, K., Shiro, Y., Abe, K. Neurosci. Lett. (1999)
- Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity. Tomizawa, K., Ohta, J., Matsushita, M., Moriwaki, A., Li, S.T., Takei, K., Matsui, H. J. Neurosci. (2002)
- Neuroadaptations of Cdk5 in cholinergic interneurons of the nucleus accumbens and prefrontal cortex of inbred alcohol-preferring rats following voluntary alcohol drinking. Camp, M.C., Mayfield, R.D., McCracken, M., McCracken, L., Alcantara, A.A. Alcohol. Clin. Exp. Res. (2006)
- Cocaine-induced proliferation of dendritic spines in nucleus accumbens is dependent on the activity of cyclin-dependent kinase-5. Norrholm, S.D., Bibb, J.A., Nestler, E.J., Ouimet, C.C., Taylor, J.R., Greengard, P. Neuroscience (2003)
- Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors. Wang, J., Liu, S., Fu, Y., Wang, J.H., Lu, Y. Nat. Neurosci. (2003)
- Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction. Fu, A.K., Fu, W.Y., Cheung, J., Tsim, K.W., Ip, F.C., Wang, J.H., Ip, N.Y. Nat. Neurosci. (2001)
- Cdk5 phosphorylates p53 and regulates its activity. Zhang, J., Krishnamurthy, P.K., Johnson, G.V. J. Neurochem. (2002)
- Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis. Gong, X., Tang, X., Wiedmann, M., Wang, X., Peng, J., Zheng, D., Blair, L.A., Marshall, J., Mao, Z. Neuron (2003)
- Cdk5 is essential for synaptic vesicle endocytosis. Tan, T.C., Valova, V.A., Malladi, C.S., Graham, M.E., Berven, L.A., Jupp, O.J., Hansra, G., McClure, S.J., Sarcevic, B., Boadle, R.A., Larsen, M.R., Cousin, M.A., Robinson, P.J. Nat. Cell Biol. (2003)
- Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses. Lee, S.Y., Wenk, M.R., Kim, Y., Nairn, A.C., De Camilli, P. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Cdk5 and Trio modulate endocrine cell exocytosis. Xin, X., Ferraro, F., Bäck, N., Eipper, B.A., Mains, R.E. J. Cell. Sci. (2004)
- Cdk5-mediated phosphorylation of Axin directs axon formation during cerebral cortex development. Fang, W.Q., Ip, J.P., Li, R., Ng, Y.P., Lin, S.C., Chen, Y., Fu, A.K., Ip, N.Y. J. Neurosci. (2011)
- L6 myoblast differentiation is modulated by Cdk5 via the PI3K-AKT-p70S6K signaling pathway. Sarker, K.P., Lee, K.Y. Oncogene (2004)
- Activation of cyclin-dependent kinase 5 is involved in axonal regeneration. Namgung, U., Choi, B.H., Park, S., Lee, J.U., Seo, H.S., Suh, B.C., Kim, K.T. Mol. Cell. Neurosci. (2004)
- Activity and regulation of p35/Cdk5 kinase complex. Nikolic, M., Tsai, L.H. Meth. Enzymol. (2000)
- Kinetics of Src homology 3 domain association with the proline-rich domain of dynamins: specificity, occlusion, and the effects of phosphorylation. Solomaha, E., Szeto, F.L., Yousef, M.A., Palfrey, H.C. J. Biol. Chem. (2005)
- Alpha2-chimaerin, cyclin-dependent Kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse. Brown, M., Jacobs, T., Eickholt, B., Ferrari, G., Teo, M., Monfries, C., Qi, R.Z., Leung, T., Lim, L., Hall, C. J. Neurosci. (2004)
- Differential cellular phosphorylation of neurofilament heavy side-arms by glycogen synthase kinase-3 and cyclin-dependent kinase-5. Guidato, S., Tsai, L.H., Woodgett, J., Miller, C.C. J. Neurochem. (1996)
- Molecular characterization of a neuronal-specific protein that stimulates the activity of Cdk5. Shetty, K.T., Kaech, S., Link, W.T., Jaffe, H., Flores, C.M., Wray, S., Pant, H.C., Beushausen, S. J. Neurochem. (1995)
- A specific interaction between muskelin and the cyclin-dependent kinase 5 activator p39 promotes peripheral localization of muskelin. Ledee, D.R., Gao, C.Y., Seth, R., Fariss, R.N., Tripathi, B.K., Zelenka, P.S. J. Biol. Chem. (2005)
- Both N-methyl-D-aspartate (NMDA) and non-NMDA receptors mediate glutamate-induced cleavage of the cyclin-dependent kinase 5 (cdk5) activator p35 in cultured rat hippocampal neurons. Kerokoski, P., Suuronen, T., Salminen, A., Soininen, H., Pirttilä, T. Neurosci. Lett. (2004)
- Induction of Cdk5 activity in rat skeletal muscle after nerve injury. Fu, W.Y., Fu, A.K., Lok, K.C., Ip, F.C., Ip, N.Y. Neuroreport (2002)
- Neuronal migration is transiently delayed by prenatal exposure to intermittent hypoxia. Zechel, J.L., Gamboa, J.L., Peterson, A.G., Puchowicz, M.A., Selman, W.R., Lust, W.D. Birth Defects Res. B Dev. Reprod. Toxicol. (2005)
- Very low levels of methylmercury induce cell death of cultured rat cerebellar neurons via calpain activation. Sakaue, M., Okazaki, M., Hara, S. Toxicology (2005)
- The effect of 'binge' cocaine administration on the expression of cyclin-dependent kinase 5 and its activator p35 in various regions of rat brain. Wedzony, K., Markowicz-Kula, K., Chocyk, A., Fijał, K., Maćkowiak, M. Brain Res. (2005)
- The levels of cdk5 and p35 proteins and tau phosphorylation are reduced during neuronal apoptosis. Kerokoski, P., Suuronen, T., Salminen, A., Soininen, H., Pirttilä, T. Biochem. Biophys. Res. Commun. (2001)