Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

PubChem16859 5-methyl-3H-furan-2-one

Synonyms: NSC-654, NSC654, CHEMBL478640, SureCN782717, CCRIS 3594, ...

Nijhoff, W.A. et al., van der Logt, E.M. et al., Nijhoff, W.A. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on NSC654

Both small and large intestinal UGT enzyme activities were increased by quercetin, alpha-angelicalactone, coumarin, curcumin and flavone [1].
The most substantial inductions were seen in oesophagus and stomach by 0.5% alpha-angelicalactone (1.9- and 2.3-fold respectively); and in small intestine, colon and liver by 0.5% combination diet (2.5-, 1.4- and 4.0-fold respectively) [2].
GST-pi was induced in the stomach by coumarin and alpha-angelicalactone (470 and 1120%) and in the pancreas by flavone (200%) [3].

Gene context of NSC654

Furthermore, dietary administration of alpha-angelicalactone and flavone, given individually or in combination, enhanced the UGT detoxification system in the liver and, to a lesser extent, in intestine [1].

Analytical, diagnostic and therapeutic context of NSC654

In general, in combination groups similar effects were seen as after treatment with alpha-angelicalactone or flavone separately [2].

References

Induction of rat hepatic and intestinal UDP-glucuronosyltransferases by naturally occurring dietary anticarcinogens. van der Logt, E.M., Roelofs, H.M., Nagengast, F.M., Peters, W.H. Carcinogenesis (2003) [Pubmed]
Enhancement of rat hepatic and gastrointestinal glutathione and glutathione S-transferases by alpha-angelicalactone and flavone. Nijhoff, W.A., Bosboom, M.A., Smidt, M.H., Peters, W.H. Carcinogenesis (1995) [Pubmed]
Quantification of induction of rat oesophageal, gastric and pancreatic glutathione and glutathione S-transferases by dietary anticarcinogens. Nijhoff, W.A., Peters, W.H. Carcinogenesis (1994) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.