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Disease relevance of Pancreas


Psychiatry related information on Pancreas


High impact information on Pancreas

  • CGRP is a 37-amino acid neuropeptide, primarily released from sensory nerves, whilst AM is produced by stimulated vascular cells, and amylin is secreted from the pancreas [11].
  • The coupling may be widespread (e.g., liver) or confined to one acinus (e.g., salivary gland and pancreas) [12].
  • The PKHD1 transcript, approximately 16 kb long, is expressed in adult and fetal kidney, liver and pancreas and is predicted to encode a large novel protein, fibrocystin, with multiple copies of a domain shared with plexins and transcription factors [13].
  • Reversal of lesions of diabetic nephropathy after pancreas transplantation [14].
  • HD mRNA was also expressed in colon, liver, pancreas and testes [15].
  • Loss of Cdk4 expression in rodents causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia [16].

Chemical compound and disease context of Pancreas


Biological context of Pancreas


Anatomical context of Pancreas


Associations of Pancreas with chemical compounds

  • Effects of pancreas transplantation on postprandial glucose metabolism [31].
  • Total parenteral nutrition and the pancreas [32].
  • Positive control of cyclic AMP on mesenchymal factor controlled DNA synthesis in embryonic pancreas [33].
  • Although primary structural homology between bacterial serine proteases and those from the mammalian pancreas is slight, two-thirds of the residues in the bacterial enzyme SGPB as seen at 2.8-A resolution, adopt a similar polypeptide chain conformation to that of the chymotrypsin family [34].
  • We recently performed a similar search in porcine pancreas and found a high concentration of a peptide having a glycine amide at its C-terminus [35].

Gene context of Pancreas

  • Of significance, CCK-A receptors were expressed selectively in all pancreatic adenocarcinomas, but not in any normal pancreas specimens [5].
  • Expression of CCK-B receptors was detected in all tissues arising from pancreas and in most extrapancreatic tissues and tumors [5].
  • In the pancreas, only glutathione peroxidase activity was affected, and it was reduced in both the BHA and BHT treatment groups [36].
  • Human kidney, lung, and pancreas showed immunohistochemical staining with an antibody to adrenal PNMT [37].
  • Confocal microscopic data indicated that CDC42 is localized only in islet endocrine cells but not in acinar cells of the pancreas [38].

Analytical, diagnostic and therapeutic context of Pancreas


  1. Linkage and association between insulin-dependent diabetes mellitus (IDDM) susceptibility and markers near the glucokinase gene on chromosome 7. Rowe, R.E., Wapelhorst, B., Bell, G.I., Risch, N., Spielman, R.S., Concannon, P. Nat. Genet. (1995) [Pubmed]
  2. Mutations in the glucokinase gene of the fetus result in reduced birth weight. Hattersley, A.T., Beards, F., Ballantyne, E., Appleton, M., Harvey, R., Ellard, S. Nat. Genet. (1998) [Pubmed]
  3. Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping. Todd, J.A., Mijovic, C., Fletcher, J., Jenkins, D., Bradwell, A.R., Barnett, A.H. Nature (1989) [Pubmed]
  4. High concentration of GABA and high glutamate decarboxylase activity in rat pancreatic islets and human insulinoma. Okada, Y., Taniguchi, H., Schimada, C. Science (1976) [Pubmed]
  5. Cholecystokinin A and B receptors are differentially expressed in normal pancreas and pancreatic adenocarcinoma. Weinberg, D.S., Ruggeri, B., Barber, M.T., Biswas, S., Miknyocki, S., Waldman, S.A. J. Clin. Invest. (1997) [Pubmed]
  6. Amyloid probes based on Congo Red distinguish between fibrils comprising different peptides. Ashburn, T.T., Han, H., McGuinness, B.F., Lansbury, P.T. Chem. Biol. (1996) [Pubmed]
  7. Insulin and insulin-like growth factor II suppress neuropeptide Y release from the nerve terminals in the paraventricular nucleus: a putative hypothalamic site for energy homeostasis. Sahu, A., Dube, M.G., Phelps, C.P., Sninsky, C.A., Kalra, P.S., Kalra, S.P. Endocrinology (1995) [Pubmed]
  8. Insulin-releasing activity and successful transplantation of pancreatic islets preserved by tissue culture. Nakagawara, G., Yamasaki, G., Kimura, S., Kojima, Y., Miyazaki, I. Surgery (1978) [Pubmed]
  9. Energy balance and cancer: the role of insulin and insulin-like growth factor-I. Kaaks, R., Lukanova, A. The Proceedings of the Nutrition Society. (2001) [Pubmed]
  10. Effects of nocturnal and diurnal food deprivation on pancreas weight, pancreas insulin content and serum glucose and insulin levels in young weaned rats. Haouari-Oukerro, F., Haouari, M., Sfaxi, A., Nagati, K., Tritar, B. Horm. Metab. Res. (1994) [Pubmed]
  11. Vascular actions of calcitonin gene-related peptide and adrenomedullin. Brain, S.D., Grant, A.D. Physiol. Rev. (2004) [Pubmed]
  12. Electrophysiology of mammalian gland cells. Petersen, O.H. Physiol. Rev. (1976) [Pubmed]
  13. The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein. Ward, C.J., Hogan, M.C., Rossetti, S., Walker, D., Sneddon, T., Wang, X., Kubly, V., Cunningham, J.M., Bacallao, R., Ishibashi, M., Milliner, D.S., Torres, V.E., Harris, P.C. Nat. Genet. (2002) [Pubmed]
  14. Reversal of lesions of diabetic nephropathy after pancreas transplantation. Fioretto, P., Steffes, M.W., Sutherland, D.E., Goetz, F.C., Mauer, M. N. Engl. J. Med. (1998) [Pubmed]
  15. Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues. Strong, T.V., Tagle, D.A., Valdes, J.M., Elmer, L.W., Boehm, K., Swaroop, M., Kaatz, K.W., Collins, F.S., Albin, R.L. Nat. Genet. (1993) [Pubmed]
  16. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Rane, S.G., Dubus, P., Mettus, R.V., Galbreath, E.J., Boden, G., Reddy, E.P., Barbacid, M. Nat. Genet. (1999) [Pubmed]
  17. Complete reversal of experimental diabetes mellitus in rats by a single fetal pancreas. Mullen, Y.S., Clark, W.R., Molnar, I.G., Brown, J. Science (1977) [Pubmed]
  18. Dietary vitamin D is essential for normal insulin secretion from the perfused rat pancreas. Kadowaki, S., Norman, A.W. J. Clin. Invest. (1984) [Pubmed]
  19. Effects of phenobarbital and secondary bile acids on liver, gallbladder, and pancreas carcinogenesis initiated by N-nitrosobis (2-hydroxypropyl)amine in hamsters. Makino, T., Obara, T., Ura, H., Kinugasa, T., Kobayashi, H., Takahashi, S., Konishi, Y. J. Natl. Cancer Inst. (1986) [Pubmed]
  20. Nonoxidative ethanol metabolites alter extracellular matrix protein content in rat pancreas. Lugea, A., Gukovsky, I., Gukovskaya, A.S., Pandol, S.J. Gastroenterology (2003) [Pubmed]
  21. Structural and hormonal alterations in the gastrointestinal tract of parenterally fed rats. Johnson, L.R., Copeland, E.M., Dudrick, S.J., Lichtenberger, L.M., Castro, G.A. Gastroenterology (1975) [Pubmed]
  22. Positive correlation between pancreatic DNA damage and species specificity in response to N-nitrosobis(2-oxopropyl)amine. Zurlo, J., Longnecker, D.S. J. Natl. Cancer Inst. (1983) [Pubmed]
  23. Macrophages, T cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes mellitus. Hänninen, A., Jalkanen, S., Salmi, M., Toikkanen, S., Nikolakaros, G., Simell, O. J. Clin. Invest. (1992) [Pubmed]
  24. Structurally abnormal insulin in a diabetic patient. Characterization of the mutant insulin A3 (Val----Leu) isolated from the pancreas. Sakura, H., Iwamoto, Y., Sakamoto, Y., Kuzuya, T., Hirata, H. J. Clin. Invest. (1986) [Pubmed]
  25. In situ hybridization shows distinct patterns of mucin gene expression in normal, benign, and malignant pancreas tissues. Balagué, C., Audié, J.P., Porchet, N., Real, F.X. Gastroenterology (1995) [Pubmed]
  26. Cholecystokinin stimulates heat shock protein 27 phosphorylation in rat pancreas both in vivo and in vitro. Groblewski, G.E., Grady, T., Mehta, N., Lambert, H., Logsdon, C.D., Landry, J., Williams, J.A. Gastroenterology (1997) [Pubmed]
  27. Identification of human glandular kallikrein in the beta cell of the pancreas. ole-MoiYoi, O.K., Pinkus, G.S., Spragg, J., Austen, K.F. N. Engl. J. Med. (1979) [Pubmed]
  28. Orexins in the brain-gut axis. Kirchgessner, A.L. Endocr. Rev. (2002) [Pubmed]
  29. Expression of a multidrug resistance gene in human cancers. Goldstein, L.J., Galski, H., Fojo, A., Willingham, M., Lai, S.L., Gazdar, A., Pirker, R., Green, A., Crist, W., Brodeur, G.M. J. Natl. Cancer Inst. (1989) [Pubmed]
  30. 5-hydroxytryptamine strongly inhibits fluid secretion in guinea pig pancreatic duct cells. Suzuki, A., Naruse, S., Kitagawa, M., Ishiguro, H., Yoshikawa, T., Ko, S.B., Yamamoto, A., Hamada, H., Hayakawa, T. J. Clin. Invest. (2001) [Pubmed]
  31. Effects of pancreas transplantation on postprandial glucose metabolism. Katz, H., Homan, M., Velosa, J., Robertson, P., Rizza, R. N. Engl. J. Med. (1991) [Pubmed]
  32. Total parenteral nutrition and the pancreas. Traverso, L.W., Abou-Zamzam, A.M. N. Engl. J. Med. (1979) [Pubmed]
  33. Positive control of cyclic AMP on mesenchymal factor controlled DNA synthesis in embryonic pancreas. Filosa, S., Pictet, R., Rutter, W. Nature (1975) [Pubmed]
  34. Tertiary structural differences between microbial serine proteases and pancreatic serine enzymes. Delbaere, L.T., Hutcheon, W.L., James, M.N., Thiessen, W.E. Nature (1975) [Pubmed]
  35. Pancreastatin, a novel pancreatic peptide that inhibits insulin secretion. Tatemoto, K., Efendić, S., Mutt, V., Makk, G., Feistner, G.J., Barchas, J.D. Nature (1986) [Pubmed]
  36. Modulation of azaserine-induced pancreatic foci by phenolic antioxidants in rats. Roebuck, B.D., MacMillan, D.L., Bush, D.M., Kensler, T.W. J. Natl. Cancer Inst. (1984) [Pubmed]
  37. Nonadrenal epinephrine-forming enzymes in humans. Characteristics, distribution, regulation, and relationship to epinephrine levels. Kennedy, B., Bigby, T.D., Ziegler, M.G. J. Clin. Invest. (1995) [Pubmed]
  38. Glucose- and GTP-dependent stimulation of the carboxyl methylation of CDC42 in rodent and human pancreatic islets and pure beta cells. Evidence for an essential role of GTP-binding proteins in nutrient-induced insulin secretion. Kowluru, A., Seavey, S.E., Li, G., Sorenson, R.L., Weinhaus, A.J., Nesher, R., Rabaglia, M.E., Vadakekalam, J., Metz, S.A. J. Clin. Invest. (1996) [Pubmed]
  39. Somatostatin: abundance of immunoreactive hormone in rat stomach and pancreas. Arimura, A., Sato, H., Dupont, A., Nishi, N., Schally, A.V. Science (1975) [Pubmed]
  40. Glucose and ATP levels in pancreatic islet tissue of normal and diabetic rats. Matschinsky, F.M., Pagliara, A.S., Stillings, S.N., Hover, B.A. J. Clin. Invest. (1976) [Pubmed]
  41. Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha. Korc, M., Chandrasekar, B., Yamanaka, Y., Friess, H., Buchier, M., Beger, H.G. J. Clin. Invest. (1992) [Pubmed]
  42. Glucagon, catecholamine and pancreatic polypeptide secretion in type I diabetic recipients of pancreas allografts. Diem, P., Redmon, J.B., Abid, M., Moran, A., Sutherland, D.E., Halter, J.B., Robertson, R.P. J. Clin. Invest. (1990) [Pubmed]
  43. Isolation, characterization, and distribution of an unusual pancreatic human secretory protein. Gross, J., Carlson, R.I., Brauer, A.W., Margolies, M.N., Warshaw, A.L., Wands, J.R. J. Clin. Invest. (1985) [Pubmed]
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