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Chemical Compound Review:

CINNAMAMIDE 3-phenylprop-2-enamide

Synonyms: AGN-PC-00PNLQ, SureCN159753, AG-B-19837, AG-E-60919, ACMC-209fqx, ...

Wu, Y.J. et al.

Wu, Boissard, Greco, Gribkoff, Harden, He, L'Heureux, Kang, Kinney, Knox, Natale, Newton, Lehtinen-Oboma, Sinz, Sivarao, Starrett, Sun, Tertyshnikova, Thompson, Weaver, Wong, Zhang, Dworetzky,

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Disease relevance of 3-phenylacrylamide

(S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: an orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine [1].

References

(S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: an orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine. Wu, Y.J., Boissard, C.G., Greco, C., Gribkoff, V.K., Harden, D.G., He, H., L'Heureux, A., Kang, S.H., Kinney, G.G., Knox, R.J., Natale, J., Newton, A.E., Lehtinen-Oboma, S., Sinz, M.W., Sivarao, D.V., Starrett, J.E., Sun, L.Q., Tertyshnikova, S., Thompson, M.W., Weaver, D., Wong, H.S., Zhang, L., Dworetzky, S.I. J. Med. Chem. (2003) [Pubmed]

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