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Chemical Compound Review:

SureCN65952 2,5-dimethyl-1H-pyrrole

Synonyms: NSC-4507, ACMC-1AUPM, AG-G-30044, ANW-34274, NSC4507, ...

Boekelheide, K. et al., Nowak, I. et al.

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High impact information on NSC4507

The resulting 2,5-dimethylpyrrole adducts were stable toward bases but were hydrolyzed with TFA/H(2)O to regenerate the amino function [1].
Rats exposed to 1.0, 0.5, or 0.25% 2,5-HD had microtubule nucleation times 55, 63, and 72% of control and pyrrole contents equivalent to 2.14, 1.40, and 1.18 nmol 2,5-dimethylpyrrole/mg testis protein [2].

References

Protection of the amino group of adenosine and guanosine derivatives by elaboration into a 2,5-dimethylpyrrole moiety. Nowak, I., Robins, M.J. Org. Lett. (2003) [Pubmed]
The rate of 2,5-hexanedione intoxication, not total dose, determines the extent of testicular injury and altered microtubule assembly in the rat. Boekelheide, K., Eveleth, J. Toxicol. Appl. Pharmacol. (1988) [Pubmed]

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