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Chemical Compound Review:

Cmpfpa 2-(2-carboxyethyl)-4-methyl- 5-propyl-furan...

Synonyms: SureCN250914, AG-H-50324, CHEMBL1231562, CHEBI:41254, AC1L3XNY, ...

Niwa, T. et al., Liebich, H.M. et al., Liebich, H.M. et al., Niwa, T. et al., Takeda, N. et al.

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Disease relevance of Cmpfpa

Apart from increased concentrations of aliphatic dicarboxylic acids and phenolic aromatic acids in plasma from patients with chronic renal failure, there is large elevation of a furanoid acid, 3-carboxy-4-methyl-5-propyl-2- furanpropionic acid, and of hippuric acid [1].
Hippuric acid and 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid in serum and urine. Analytical approaches and clinical relevance in kidney diseases [2].

High impact information on Cmpfpa

Hippuric acid (HA) and 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid (FA) were determined in serum, plasma, ultrafiltrate and urine by gas chromatography (GC), high-performance liquid chromatography and GC with mass-selective detection, and the methods were compared [2].
These results suggest that the efficient removal by CAPD of 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid, an inhibitor of erythropoiesis, is related to an improvement of anemia in patients on CAPD [3].

Analytical, diagnostic and therapeutic context of Cmpfpa

The isolated compound was identified as 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid by use of liquid secondary-ion mass spectrometry and gas chromatography-mass spectrometry [4].
3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid was also quantitated in uremic serum by high-performance liquid chromatography [5].
Mass chromatography revealed that the serum concentrations of the furancarboxylic acids especially 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid, were increased in the chronic hemodialysis patients and that the acids could not be removed by conventional hemodialysis due to their strong binding to plasma protein [5].

References

Gas chromatographic and gas chromatographic-mass spectrometric analysis of organic acids in plasma of patients with chronic renal failure. Liebich, H.M., Pickert, A., Tetschner, B. J. Chromatogr. (1984) [Pubmed]
Hippuric acid and 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid in serum and urine. Analytical approaches and clinical relevance in kidney diseases. Liebich, H.M., Bubeck, J.I., Pickert, A., Wahl, G., Scheiter, A. J. Chromatogr. (1990) [Pubmed]
Efficient removal of albumin-bound furancarboxylic acid, an inhibitor of erythropoiesis, by continuous ambulatory peritoneal dialysis. Niwa, T., Yazawa, T., Kodama, T., Uehara, Y., Maeda, K., Yamada, K. Nephron (1990) [Pubmed]
Identification and quantification of a protein-bound ligand in uremic serum. Takeda, N., Niwa, T., Tatematsu, A., Suzuki, M. Clin. Chem. (1987) [Pubmed]
Accumulation of furancarboxylic acids in uremic serum as inhibitors of drug binding. Niwa, T., Takeda, N., Maeda, K., Shibata, M., Tatematsu, A. Clin. Chim. Acta (1988) [Pubmed]

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