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MeSH Review


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Disease relevance of Erythropoiesis


Psychiatry related information on Erythropoiesis


High impact information on Erythropoiesis

  • The p38alpha MAP kinase plays a critical role linking developmental and stress-induced erythropoiesis through regulation of Epo expression [7].
  • To test the hypothesis that the Trf cycle has unique importance for erythropoiesis, we disrupted the Trfr gene in mice [8].
  • Mice lacking Trfr have a more severe phenotype than hpx mice, affecting both erythropoiesis and neurologic development [8].
  • Stat5 is rapidly activated following EpoR stimulation, but its function in erythropoiesis has been unclear since adult Stat5a-/-5b-/- mice have normal steady-state hematocrit [9].
  • SOCS3 is essential in the regulation of fetal liver erythropoiesis [10].

Chemical compound and disease context of Erythropoiesis


Biological context of Erythropoiesis


Anatomical context of Erythropoiesis


Associations of Erythropoiesis with chemical compounds


Gene context of Erythropoiesis

  • Both types of mutations exhibited identical phenotypes, indicating that EPO and the EPOR are crucial for definitive erythropoiesis in vivo and that no other ligands or receptors can replace them [30].
  • Homozygous inactivation of the Rb gene in the mouse leads to mid-gestational lethality with defects in erythropoiesis and neurogenesis [31].
  • Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver [32].
  • In addition, the proliferative reserves of hematopoietic progenitors and stress erythropoiesis were significantly reduced in Ercc1-/- mice compared to age-matched controls [33].
  • Since both RBTN2 and TAL1 are crucial for normal erythropoiesis, these data have important implications for transcription networks therein [34].

Analytical, diagnostic and therapeutic context of Erythropoiesis


  1. Serum erythropoietin levels after renal transplantation. Sun, C.H., Ward, H.J., Paul, W.L., Koyle, M.A., Yanagawa, N., Lee, D.B. N. Engl. J. Med. (1989) [Pubmed]
  2. Effects of oxygen inhalation on endogenous erythropoietin kinetics, erythropoiesis, and properties of blood cells in sickle-cell anemia. Embury, S.H., Garcia, J.F., Mohandas, N., Pennathur-Das, R., Clark, M.R. N. Engl. J. Med. (1984) [Pubmed]
  3. Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. Brusselmans, K., Compernolle, V., Tjwa, M., Wiesener, M.S., Maxwell, P.H., Collen, D., Carmeliet, P. J. Clin. Invest. (2003) [Pubmed]
  4. Identification of spermine as an inhibitor of erythropoiesis in patients with chronic renal failure. Radtke, H.W., Rege, A.B., LaMarche, M.B., Bartos, D., Bartos, F., Campbell, R.A., Fisher, J.W. J. Clin. Invest. (1981) [Pubmed]
  5. Lack of angiotensin II-facilitated erythropoiesis causes anemia in angiotensin-converting enzyme-deficient mice. Cole, J., Ertoy, D., Lin, H., Sutliff, R.L., Ezan, E., Guyene, T.T., Capecchi, M., Corvol, P., Bernstein, K.E. J. Clin. Invest. (2000) [Pubmed]
  6. Role of the central nervous system in hemopoiesis regulation during experimental neuroses. Skurikhin, E.G., Dygai, A.M., Suslov, N.I., Provalova, N.V., Zyuz'kov, G.N., Gol'dberg, E.D. Bull. Exp. Biol. Med. (2001) [Pubmed]
  7. Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Tamura, K., Sudo, T., Senftleben, U., Dadak, A.M., Johnson, R., Karin, M. Cell (2000) [Pubmed]
  8. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Levy, J.E., Jin, O., Fujiwara, Y., Kuo, F., Andrews, N.C. Nat. Genet. (1999) [Pubmed]
  9. Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction. Socolovsky, M., Fallon, A.E., Wang, S., Brugnara, C., Lodish, H.F. Cell (1999) [Pubmed]
  10. SOCS3 is essential in the regulation of fetal liver erythropoiesis. Marine, J.C., McKay, C., Wang, D., Topham, D.J., Parganas, E., Nakajima, H., Pendeville, H., Yasukawa, H., Sasaki, A., Yoshimura, A., Ihle, J.N. Cell (1999) [Pubmed]
  11. Vanadium stimulates the (Na+,K+) pump in friend erythroleukemia cells and blocks erythropoiesis. English, L.H., Macara, I.G., Cantley, L.C. J. Cell Biol. (1983) [Pubmed]
  12. Aplastic anemia with fetallike erythropoiesis following androgen therapy. Rao, A.N., Brown, A.K., Rieder, R.F., Clegg, J.B., Marsh, W.L. Blood (1978) [Pubmed]
  13. Pure red cell aplasia (PRCA): Response of three patients of cyclophosphamide and/or antilymphocyte globulin (ALG) and demonstration of two types of serum IgG inhibitors to erythropoiesis. Marmont, A., Peschle, C., Sanguineti, M., Condorelli, M. Blood (1975) [Pubmed]
  14. Response of Diamond-Blackfan anemia to metoclopramide: evidence for a role for prolactin in erythropoiesis. Abkowitz, J.L., Schaison, G., Boulad, F., Brown, D.L., Buchanan, G.R., Johnson, C.A., Murray, J.C., Sabo, K.M. Blood (2002) [Pubmed]
  15. Remodeling the regulation of iron metabolism during erythroid differentiation to ensure efficient heme biosynthesis. Schranzhofer, M., Schifrer, M., Cabrera, J.A., Kopp, S., Chiba, P., Beug, H., Müllner, E.W. Blood (2006) [Pubmed]
  16. DNA ligase I is required for fetal liver erythropoiesis but is not essential for mammalian cell viability. Bentley, D., Selfridge, J., Millar, J.K., Samuel, K., Hole, N., Ansell, J.D., Melton, D.W. Nat. Genet. (1996) [Pubmed]
  17. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Neubauer, H., Cumano, A., Müller, M., Wu, H., Huffstadt, U., Pfeffer, K. Cell (1998) [Pubmed]
  18. A truncated erythropoietin receptor that fails to prevent programmed cell death of erythroid cells. Nakamura, Y., Komatsu, N., Nakauchi, H. Science (1992) [Pubmed]
  19. FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Mahon, P.C., Hirota, K., Semenza, G.L. Genes Dev. (2001) [Pubmed]
  20. The glucocorticoid receptor is required for stress erythropoiesis. Bauer, A., Tronche, F., Wessely, O., Kellendonk, C., Reichardt, H.M., Steinlein, P., Schütz, G., Beug, H. Genes Dev. (1999) [Pubmed]
  21. Erythropoiesis in familial erythrocytosis. Greenberg, B.R., Golde, D.W. N. Engl. J. Med. (1977) [Pubmed]
  22. Interaction of the erythropoietin and stem-cell-factor receptors. Wu, H., Klingmüller, U., Besmer, P., Lodish, H.F. Nature (1995) [Pubmed]
  23. Constitutive c-myc oncogene expression blocks mouse erythroleukaemia cell differentiation but not commitment. Coppola, J.A., Cole, M.D. Nature (1986) [Pubmed]
  24. Erythropoietin-independent erythrocyte production: signals through gp130 and c-kit dramatically promote erythropoiesis from human CD34+ cells. Sui, X., Tsuji, K., Tajima, S., Tanaka, R., Muraoka, K., Ebihara, Y., Ikebuchi, K., Yasukawa, K., Taga, T., Kishimoto, T., Nakahata, T. J. Exp. Med. (1996) [Pubmed]
  25. Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy. Kaushansky, K., Broudy, V.C., Grossmann, A., Humes, J., Lin, N., Ren, H.P., Bailey, M.C., Papayannopoulou, T., Forstrom, J.W., Sprugel, K.H. J. Clin. Invest. (1995) [Pubmed]
  26. Suppression of hematopoietic-progenitor-cell proliferation by ethanol and acetaldehyde. Meagher, R.C., Sieber, F., Spivak, J.L. N. Engl. J. Med. (1982) [Pubmed]
  27. A developmental transition in definitive erythropoiesis: erythropoietin expression is sequentially regulated by retinoic acid receptors and HNF4. Makita, T., Hernandez-Hoyos, G., Chen, T.H., Wu, H., Rothenberg, E.V., Sucov, H.M. Genes Dev. (2001) [Pubmed]
  28. A quest for erythropoietin over nine decades. Fisher, J.W. Annu. Rev. Pharmacol. Toxicol. (1998) [Pubmed]
  29. Effect of perturbation of specific folate receptors during in vitro erythropoiesis. Antony, A.C., Bruno, E., Briddell, R.A., Brandt, J.E., Verma, R.S., Hoffman, R. J. Clin. Invest. (1987) [Pubmed]
  30. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Wu, H., Liu, X., Jaenisch, R., Lodish, H.F. Cell (1995) [Pubmed]
  31. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Morgenbesser, S.D., Williams, B.O., Jacks, T., DePinho, R.A. Nature (1994) [Pubmed]
  32. Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. Gunshin, H., Fujiwara, Y., Custodio, A.O., Direnzo, C., Robine, S., Andrews, N.C. J. Clin. Invest. (2005) [Pubmed]
  33. Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient Ercc1-/- mice. Prasher, J.M., Lalai, A.S., Heijmans-Antonissen, C., Ploemacher, R.E., Hoeijmakers, J.H., Touw, I.P., Niedernhofer, L.J. EMBO J. (2005) [Pubmed]
  34. The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells. Valge-Archer, V.E., Osada, H., Warren, A.J., Forster, A., Li, J., Baer, R., Rabbitts, T.H. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  35. Mechanisms of developmental control of transcription in the murine alpha- and beta-globin loci. Trimborn, T., Gribnau, J., Grosveld, F., Fraser, P. Genes Dev. (1999) [Pubmed]
  36. Hematopoietic stem cells in Friend murine leukemia virus-infected mice undergoing chemotherapy: remission and relapse of erythropoietin-independent erythropoiesis induced by hydroxyurea. Seidel, H.J., Opitz, U. J. Natl. Cancer Inst. (1979) [Pubmed]
  37. Erythropoietin reduces myocardial infarction and left ventricular functional decline after coronary artery ligation in rats. Moon, C., Krawczyk, M., Ahn, D., Ahmet, I., Paik, D., Lakatta, E.G., Talan, M.I. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  38. Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif. Ruff, P., Speicher, D.W., Husain-Chishti, A. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  39. Evidence for ineffective erythropoiesis in severe sickle cell disease. Wu, C.J., Krishnamurti, L., Kutok, J.L., Biernacki, M., Rogers, S., Zhang, W., Antin, J.H., Ritz, J. Blood (2005) [Pubmed]
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