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Chemical Compound Review:

KST-1B7427 (2R,3R,4S,5R)-2-(5-amino- 4,7,9...

Synonyms: AC1L2OXH, AR-1B9405, AC1Q4WB1, 3-Deaza-siba, 67377-76-8, ...

Toyoshima, S. et al., Godeau, F. et al., Chiang, P.K. et al., Smejkal, R.M. et al.

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Disease relevance of S-Isobutyryl-3-deaza-adenosine

Adenosylhomocysteine hydrolase inhibitors: synthesis of 5'-deoxy-5'-(isobutylthio)-3-deazaadenosine and its effect on Rous sarcoma virus and Gross murine leukemia virus [1].

High impact information on S-Isobutyryl-3-deaza-adenosine

The lectin-stimulated increase in phospholipid methylation occurred in calcium-free medium, while the inhibitor of phospholipid methylation, 3-deaza-SIBA, also suppressed the increased calcium influx [2].
2. At 0.01-1.0 microM, stimulation of [3H]QNB and NMS-inaccessible [3H]QNB binding was observed, with the most induced by 1 microM 3-deaza-SIBA [3].

Associations of S-Isobutyryl-3-deaza-adenosine with other chemical compounds

Methyltransferase inhibitors, 3-deaza-SIBA, SIBA, and Sinefungin, inhibited progesterone-activated stimulation of phospholipid methylation, calcium uptake and meiotic maturation [4].

References

Adenosylhomocysteine hydrolase inhibitors: synthesis of 5'-deoxy-5'-(isobutylthio)-3-deazaadenosine and its effect on Rous sarcoma virus and Gross murine leukemia virus. Chiang, P.K., Cantoni, G.L., Bader, J.P., Shannon, W.M., Thomas, H.J., Montgomery, J.A. Biochem. Biophys. Res. Commun. (1978) [Pubmed]
The relationship between phospholipid methylation and calcium influx in murine lymphocytes stimulated with native and modified Con A. Toyoshima, S., Hirata, F., Axelrod, J., Beppu, M., Osawa, T., Waxdal, M.J. Mol. Immunol. (1982) [Pubmed]
Muscarinic receptor subtype specificity of 5'-(isobutylthio)-adenosine (SIBA) and its analogs. Smejkal, R.M., Abalis, I., Pankaskie, M.C., Chiang, P.K. Gen. Pharmacol. (1989) [Pubmed]
Early stimulation of phospholipid methylation in Xenopus oocytes by progesterone. Godeau, F., Ishizaka, T., Koide, S.S. Cell Differ. (1985) [Pubmed]

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