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MeSH Review

Sarcoma, Avian

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Disease relevance of Sarcoma, Avian


High impact information on Sarcoma, Avian


Chemical compound and disease context of Sarcoma, Avian

  • In addition, FSV P130 and p60src of Rous sarcoma virus were 40% homologous in the region of the carboxyterminal 280 amino acids, which includes the phosphoacceptor tyrosine residue [10].
  • When mRNA for avian retroviral envolope glycoprotein (env) was injected into cells transformed by env-deficient Bryan Rous sarcoma virus, the env deficiency of the injected cells was complemented to allow the release of transforming virus for up to 40 hr [11].
  • The gag-related proteins encoded by these avian sarcoma viruses (ASVs) were all associated with tyrosine-specific protein kinase activity when assayed in immune complexes and were phosphorylated at both tyrosine and serine residues in vivo [1].
  • The lipid associated with p60src, the transforming protein of Rous sarcoma virus, is located in the NH2-terminal domain of the polypeptide [12].
  • Interaction of tryptophan transfer RNA with Rous sarcoma virus 35S RNA [13].

Biological context of Sarcoma, Avian


Anatomical context of Sarcoma, Avian


Gene context of Sarcoma, Avian


Analytical, diagnostic and therapeutic context of Sarcoma, Avian


  1. Transforming proteins of some feline and avian sarcoma viruses are related structurally and functionally. Beemon, K. Cell (1981) [Pubmed]
  2. Hormonal regulation of the Rous sarcoma virus src gene via a heterologous promoter defines a threshold dose for cellular transformation. Jakobovits, E.B., Majors, J.E., Varmus, H.E. Cell (1984) [Pubmed]
  3. Activating SRC mutation in a subset of advanced human colon cancers. Irby, R.B., Mao, W., Coppola, D., Kang, J., Loubeau, J.M., Trudeau, W., Karl, R., Fujita, D.J., Jove, R., Yeatman, T.J. Nat. Genet. (1999) [Pubmed]
  4. Changes in integrin receptors on oncogenically transformed cells. Plantefaber, L.C., Hynes, R.O. Cell (1989) [Pubmed]
  5. No expression of a Rous sarcoma virus-induced tumor antigen in mammalian cells infected with retroviruses transducing other oncogenes of the src gene family. Kuzumaki, N., Yamagiwa, S., Oikawa, T. J. Natl. Cancer Inst. (1985) [Pubmed]
  6. A receptor for subgroup A Rous sarcoma virus is related to the low density lipoprotein receptor. Bates, P., Young, J.A., Varmus, H.E. Cell (1993) [Pubmed]
  7. Transformation by Rous sarcoma virus induces a novel gene with homology to a mitogenic platelet protein. Sugano, S., Stoeckle, M.Y., Hanafusa, H. Cell (1987) [Pubmed]
  8. Rous sarcoma virus transforming protein lacking myristic acid phosphorylates known polypeptide substrates without inducing transformation. Kamps, M.P., Buss, J.E., Sefton, B.M. Cell (1986) [Pubmed]
  9. Protein phosphorylation at tyrosine is induced by the v-erbB gene product in vivo and in vitro. Gilmore, T., DeClue, J.E., Martin, G.S. Cell (1985) [Pubmed]
  10. Nucleotide sequence of Fujinami sarcoma virus: evolutionary relationship of its transforming gene with transforming genes of other sarcoma viruses. Shibuya, M., Hanafusa, H. Cell (1982) [Pubmed]
  11. Expression of a subgenomic retroviral messenger RNA. Stacey, D.W. Cell (1980) [Pubmed]
  12. The transforming proteins of Rous sarcoma virus, Harvey sarcoma virus and Abelson virus contain tightly bound lipid. Sefton, B.M., Trowbridge, I.S., Cooper, J.A., Scolnick, E.M. Cell (1982) [Pubmed]
  13. Interaction of tryptophan transfer RNA with Rous sarcoma virus 35S RNA. Eiden, J.J., Quade, K., Nichols, J.L. Nature (1976) [Pubmed]
  14. Evidence that the phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virus. Sefton, B.M., Hunter, T., Beemon, K., Eckhart, W. Cell (1980) [Pubmed]
  15. Molecular cloning and characterization of the chicken gene homologous to the transforming gene of Rous sarcoma virus. Shalloway, D., Zelenetz, A.D., Cooper, G.M. Cell (1981) [Pubmed]
  16. Detection of virus-specific sequences in Drosophila melanogaster mutants induced by injection of RSV DNA into early embryos. Tatosyan, A.G., Nabirochkin, S.D., Shakhbazyan, A.K., Gazaryan, K.G., Kisseljov, F.L. Nature (1984) [Pubmed]
  17. Transforming activity of polyoma virus middle-T antigen probed by site-directed mutagenesis. Oostra, B.A., Harvey, R., Ely, B.K., Markham, A.F., Smith, A.E. Nature (1983) [Pubmed]
  18. Expression of the Rous sarcoma virus pol gene by ribosomal frameshifting. Jacks, T., Varmus, H.E. Science (1985) [Pubmed]
  19. An N-terminal peptide from p60src can direct myristylation and plasma membrane localization when fused to heterologous proteins. Pellman, D., Garber, E.A., Cross, F.R., Hanafusa, H. Nature (1985) [Pubmed]
  20. R-type virus-like particles in avian sarcoma virus-induced rat central nervous system tumors. Cloyd, M.W., Burger, P.C., Bigner, D.D. J. Natl. Cancer Inst. (1975) [Pubmed]
  21. A cellular protein phosphorylated by the avian sarcoma virus transforming gene product is associated with ribonucleoprotein particles. Arrigo, A.P., Darlix, J.L., Spahr, P.F. EMBO J. (1983) [Pubmed]
  22. A molecular defect in virally transformed muscle cells that cannot cluster acetylcholine receptors. Anthony, D.T., Jacobs-Cohen, R.J., Marazzi, G., Rubin, L.L. J. Cell Biol. (1988) [Pubmed]
  23. Organization of pp60src and selected cytoskeletal proteins within adhesion plaques and junctions of Rous sarcoma virus-transformed rat cells. Shriver, K., Rohrschneider, L. J. Cell Biol. (1981) [Pubmed]
  24. Mediation of wound-related Rous sarcoma virus tumorigenesis by TGF-beta. Sieweke, M.H., Thompson, N.L., Sporn, M.B., Bissell, M.J. Science (1990) [Pubmed]
  25. Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites. Ren, R., Ye, Z.S., Baltimore, D. Genes Dev. (1994) [Pubmed]
  26. A new Drosophila Ca2+/calmodulin-dependent protein kinase (Caki) is localized in the central nervous system and implicated in walking speed. Martin, J.R., Ollo, R. EMBO J. (1996) [Pubmed]
  27. Talin is phosphorylated on tyrosine in chicken embryo fibroblasts transformed by Rous sarcoma virus. Pasquale, E.B., Maher, P.A., Singer, S.J. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  28. Chromosome assignments of four mouse cellular homologs of sarcoma and leukemia virus oncogenes. Sakaguchi, A.Y., Lalley, P.A., Zabel, B.U., Ellis, R.W., Scolnick, E.M., Naylor, S.L. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  29. Failure to confirm evidence for a nonvirion tumor-specific surface antigen in avian retrovirus-transformed cells. Phillips, E.R., Perdue, J.F. J. Natl. Cancer Inst. (1979) [Pubmed]
  30. Adhesion plaques of Rous sarcoma virus-transformed cells contain the src gene product. Rohrschneider, L.R. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  31. Oligomeric structure of a prototype retrovirus glycoprotein. Einfeld, D., Hunter, E. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  32. Alteration of neural cell adhesion molecule (N-CAM) expression after neuronal cell transformation by Rous sarcoma virus. Greenberg, M.E., Brackenbury, R., Edelman, G.M. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  33. Purification of the Rous sarcoma virus src kinase by casein-agarose and tyrosine-agarose affinity chromatography. Fukami, Y., Lipmann, F. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
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