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Chemical Compound Review:

Isohexoate 4-methylpentanoic acid

Synonyms: Isocaproate, Isohexanoate, Isohexoic acid, AGN-PC-001EPC, NSC-4126, ...

Ottesen, I. et al., Hassan, H. et al., Jouvet, P. et al., Gianfrilli, P. et al., Gunasegaram, R. et al.

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Disease relevance of Isobutylacetic acid

Direct gas-liquid chromatography of faecal specimens with isocaproic acid as a marker was used for the rapid diagnosis of Clostridium difficile associated diarrhoeal diseases [1].

High impact information on Isobutylacetic acid

In the present study, increased concentrations of MSUD metabolites, in particular alpha-keto isocaproic acid, specifically induced apoptosis in glial and neuronal cells in culture [2].
Mitochondria isolated from skeletal red muscle of rainbow trout (Salmo gairdnerii) have remarkably high activity of branched chain alpha-keto acid dehydrogenase as measured with alpha-keto isocaproic acid as substrate [3].

Analytical, diagnostic and therapeutic context of Isobutylacetic acid

Using the reverse-isotope dilution technique, (14C) isocaproic acid was isolated and characterized [4].
The detection of isocaproic acid by GLC together with the presence of presumptive colonies on primary selective culture media provides a more rapid laboratory diagnosis for Clostridium difficile [5].

References

Evaluation of gas-liquid chromatography for the rapid diagnosis of Clostridium difficile associated disease. Gianfrilli, P., Pantosti, A., Luzzi, I. J. Clin. Pathol. (1985) [Pubmed]
Branched chain amino acids induce apoptosis in neural cells without mitochondrial membrane depolarization or cytochrome c release: implications for neurological impairment associated with maple syrup urine disease. Jouvet, P., Rustin, P., Taylor, D.L., Pocock, J.M., Felderhoff-Mueser, U., Mazarakis, N.D., Sarraf, C., Joashi, U., Kozma, M., Greenwood, K., Edwards, A.D., Mehmet, H. Mol. Biol. Cell (2000) [Pubmed]
Branched chain alpha-keto acid dehydrogenase in tissues from rainbow trout (Salmo gairdnerii). Ottesen, I., Klungsøyr, L. Comp. Biochem. Physiol., B (1984) [Pubmed]
Cigarette smoke-induced cholesterol C-20, 22-desmolase inhibition in pregnancy. Gunasegaram, R., Loganath, A., Peh, K.L., Karim, S.M., Ratnam, S.S. Ann. Acad. Med. Singap. (1982) [Pubmed]
Detection of Clostridium difficile from an enhancement broth by gas-liquid chromatography. Hassan, H., Cheng, S.C. The Malaysian journal of pathology. (1991) [Pubmed]

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