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Chemical Compound Review:

SureCN10490275 2-(fluoranthen-3- ylmethylamino)-2-methyl...

Synonyms: AC1L2PHK, 773U82, 96404-52-3, 773U82 Mesylate

Trump, D.L. et al., Bair, K.W. et al.

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Disease relevance of 773U82

773U82 mesylate is not active in pancreatic cancer [1].
Toxicity of 773U82 mesylate was myelosuppression which was not prohibitive [1].

High impact information on 773U82

Three AMAP congeners (crisnatol (770U82, 773U82, and 502U83) are currently in clinical trials [2].
Phase II evaluation of the AMAP, 773U82 mesylate, in pancreatic cancer [1].

References

Phase II evaluation of the AMAP, 773U82 mesylate, in pancreatic cancer. Trump, D.L., Hathorn, J.A., Grochow, L.B., Spriggs, D., Eble, M.L., Hohneker, J.A. Investigational new drugs. (1994) [Pubmed]
2-[(arylmethyl) amino]-2-methyl-1,3-propanediol DNA intercalators. An examination of the effects of aromatic ring variation on antitumor activity and DNA binding. Bair, K.W., Andrews, C.W., Tuttle, R.L., Knick, V.C., Cory, M., McKee, D.D. J. Med. Chem. (1991) [Pubmed]

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