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Chemical Compound Review:

AC1L2PIH [5-(6-aminopurin-9-yl)-4- hydroxy-2...

Synonyms: AC1Q5BQU, AR-1L3801, 2-Octynoyl-coa, Coenzyme A, 2-octynoyl-, Coenzyme A, S-2-octynoate

Zhou, J.Z. et al., Eder, M. et al.

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High impact information on Coenzyme A, 2-octynoyl-

Both LCADH are inactivated by the substrate analogue 2-octynoyl-CoA, possibly via covalent modification of Glu261, the active-site residue involved in deprotonation of the substrate (alpha)C-H [1].
Inactivation of two-electron reduced medium chain acyl-CoA dehydrogenase by 2-octynoyl-CoA [2].

Associations of Coenzyme A, 2-octynoyl- with other chemical compounds

The acetylenic thioester, 2-octynoyl-CoA, inactivates medium chain acyl-CoA dehydrogenase from pig kidney by two distinct pathways depending on the redox state of the FAD prosthetic group [2].

References

Characterization of human and pig kidney long-chain-acyl-CoA dehydrogenases and their role in beta-oxidation. Eder, M., Kräutle, F., Dong, Y., Vock, P., Kieweg, V., Kim, J.J., Strauss, A.W., Ghisla, S. Eur. J. Biochem. (1997) [Pubmed]
Inactivation of two-electron reduced medium chain acyl-CoA dehydrogenase by 2-octynoyl-CoA. Zhou, J.Z., Thorpe, C. Arch. Biochem. Biophys. (1989) [Pubmed]

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