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Chemical Compound Review:

CCRIS 3576 phenazine-1,2-diamine

Synonyms: AG-E-36460, SureCN1856937, AC1L1ZYC, CTK0H2228, LS-103012, ...

Hempen, C. et al., Soulis, T. et al., Watanabe, T. et al., Fu, P.K. et al.

Fu, Abuzakhm, Turro,

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High impact information on CCRIS 3576

Both aminoguanidine and 2,3 diaminophenazine reduced the formation of advanced glycation end-products as measured by radioimmunoassay and as assessed immunohistochemically in these vessels [1].
Photoinduced DNA cleavage and cellular damage in human dermal fibroblasts by 2,3-diaminophenazine [2].

Analytical, diagnostic and therapeutic context of CCRIS 3576

The major mutagenic oxidation products of m-PD/p-PD and o-PD/p-PD were identified as 2,7- and 2,3-diaminophenazine, respectively, by TLC and HPLC [3].
Liquid chromatography with UV/Vis and mass spectrometric detection as well as exact mass measurements after LC fraction collection have led to the unambiguous identification of 2,3-diaminophenazine as main reaction product [4].

References

A novel inhibitor of advanced glycation end-product formation inhibits mesenteric vascular hypertrophy in experimental diabetes. Soulis, T., Sastra, S., Thallas, V., Mortensen, S.B., Wilken, M., Clausen, J.T., Bjerrum, O.J., Petersen, H., Lau, J., Jerums, G., Boel, E., Cooper, M.E. Diabetologia (1999) [Pubmed]
Photoinduced DNA cleavage and cellular damage in human dermal fibroblasts by 2,3-diaminophenazine. Fu, P.K., Abuzakhm, S., Turro, C. Photochem. Photobiol. (2005) [Pubmed]
The mutagenic modulating effect of p-phenylenediamine on the oxidation of o- or m-phenylenediamine with hydrogen peroxide in the Salmonella test. Watanabe, T., Hirayama, T., Fukui, S. Mutat. Res. (1990) [Pubmed]
Liquid chromatographic/mass spectrometric investigation on the reaction products in the peroxidase-catalyzed oxidation of o-phenylenediamine by hydrogen peroxide. Hempen, C., van Leeuwen, S.M., Luftmann, H., Karst, U. Analytical and bioanalytical chemistry. (2005) [Pubmed]

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